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Product Details
14798-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
DDX39B Fusion Protein Ag6512 (80-428 aa encoded by BC000361)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody may cross-react with DDX39A.
Immunogen sequence: ILGMDVLCQ AKSGMGKTAV FVLATLQQLE PVTGQVSVLV MCHTRELAFQ ISKEYERFSK YMPNVKVAVF FGGLSIKKDE EVLKKNCPHI VVGTPGRILA LARNKSLNLK HIKHFILDEC DKMLEQLDMR RDVQEIFRMT PHEKQVMMFS ATLSKEIRPV CRKFMQDPME IFVDDETKLT LHGLQQYYVK LKDNEKNRKL FDLLDVLEFN QVVIFVKSVQ RCIALAQLLV EQNFPAIAIH RGMPQEERLS RYQQFKDFQR RILVATNLFG RGMDIERVNI AFNYDMPEDS DTYLHRVARA GRFGTKGLAI TFVSDENDAK ILNDVQDRFE VNISELPDEI DISSYIEQTR (80-428 aa encoded by BC000361)
Target Information
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; D17H6S81E-1; D20H6S81e; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; HLA-B associated transcript 1; HLA-B associated transcript 1A; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; Nuclear RNA helicase; nuclear RNA helicase (DEAD family); nuclear RNA helicase Bat1; spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B
Gene Aliases: 0610030D10Rik; AI428441; Bat-1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; p47; UAP56
UniProt ID: (Human) Q13838, (Rat) Q63413, (Mouse) Q9Z1N5
Entrez Gene ID: (Human) 7919, (Rat) 114612, (Mouse) 53817
ATP-dependent RNA helicase activity
protein binding
ATP binding
RNA-dependent ATPase activity
ATPase activity
U6 snRNA binding
U4 snRNA binding
protein complex binding
ATP-dependent protein binding
poly(A) RNA binding
nucleotide binding
nucleic acid binding
RNA binding
helicase activity
hydrolase activity
spliceosomal complex assembly
mRNA splicing, via spliceosome
liver development
termination of RNA polymerase II transcription
RNA export from nucleus
mRNA export from nucleus
RNA splicing
RNA secondary structure unwinding
mRNA 3'-end processing
positive regulation of DNA-templated transcription, elongation
positive regulation of translation
viral mRNA export from host cell nucleus
positive regulation of cell growth involved in cardiac muscle cell development
positive regulation of vascular smooth muscle cell proliferation
negative regulation of DNA damage checkpoint
positive regulation of DNA biosynthetic process
mRNA processing
transport
cellular response to DNA damage stimulus
regulation of gene expression
mRNA transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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