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Invitrogen
RANK Monoclonal Antibody (9A725), PE
FIGURE: 1 / 3
RANK Antibody (MA1-41015) in Flow
Flow cytometry of RANK in K-562 cells (blue) and a matched isotype control (orange). Samples were incubated in RANK monoclonal antibody (Product # MA1-41015) using a dilution of 1 µg/mL for 30 minutes at room temperature. Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Both antibodies were conjugated to Phycoerythrin.
Product Details
MA1-41015
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Avian,
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
9A725
Immunogen
Fusion protein containing residues 326-616 of human RANK.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Concentration
0.43 mg/mL
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_1087023
Product Specific Information
This antibody recognizes an epitope located between amino acid residues 330-427 of human RaNK.^M
^M
Suggested positive control: Raw.
Target Information
RANK is a member of the tumor necrosis factor receptor (TNFR) family. The full length mouse RANK cDNA encodes a type I transmembrane protein with an extracellular and a cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNFR family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD265; loss of heterozygosity, 18, chromosomal region 1; ODFR; Osteoclast differentiation factor receptor; Paget disease of bone 2; receptor activator of NF-kappaB; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; Tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily member 11a, NFKB activator; tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Gene Aliases: CD265; FEO; LOH18CR1; Ly109; mRANK; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; RGD1563614; TNFRSF11A; TRANCE-R; TRANCER
UniProt ID: (Human) Q9Y6Q6, (Mouse) O35305
Entrez Gene ID: (Human) 8792, (Mouse) 21934, (Rat) 498206
ossification
adaptive immune response
monocyte chemotaxis
inflammatory response
signal transduction
cell-cell signaling
positive regulation of cell proliferation
response to radiation
osteoclast differentiation
response to lipopolysaccharide
tumor necrosis factor-mediated signaling pathway
response to cytokine
response to tumor necrosis factor
regulation of apoptotic process
positive regulation of JUN kinase activity
lymph node development
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of NF-kappaB transcription factor activity
circadian temperature homeostasis
mammary gland alveolus development
response to interleukin-1
positive regulation of fever generation by positive regulation of prostaglandin secretion
TNFSF11-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
apoptotic signaling pathway
multicellular organism development
programmed cell death
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