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CD105 Monoclonal Antibody (SN6), PE

FIGURE: 1 / 1

CD105 Antibody (MA1-80944) in Flow

PloS one 2019 - Fig 1 MSCs derived from horse peripheral blood expressed typical MSC markers and reduced lameness in horses with osteoarthritis. (A) Representative phenotype of MSC, gray line represents unstained cells; the red filled line represents cells stained with individual specific antibodies (CD105, CD146, CD90, CD73). (B) The AAEP lameness scale was used for grading lameness before and after six weeks. Autologous ... View More

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Product Details

MA1-80944

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

Neat

View 5 publications 5 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Horse, Human, Non-human primate

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

SN6

Immunogen

Cell membrane antigens from fresh leukemia cells.

View immunogen

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Lyophilized

Concentration

Conc. Not Determined

Purification

Protein A

Storage buffer

PBS, pH 7.4, with 1% BSA, 5% sucrose

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_927393

Product Specific Information

Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4ºC in the dark.

For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.

Mouse anti Human CD105 antibody, clone SN6 recognizes the human endoglin, also known as CD105. CD105 is a glycoprotein homodimer of approximately 95 kDa subunits expressed by endothelial cells, activated monocytes and some leukemia cells.

Target Information

CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Therapeutic Potential of Mesenchymal Stem Cells in a Pre-Clinical Model of Diabetic Kidney Disease and Obesity.

International journal of molecular sciences

Sávio-Silva C,Soinski-Sousa PE,Simplício-Filho A,Bastos RMC,Beyerstedt S,Rangel ÉB

MA1-80944 was used in Flow Cytometry to investigate mitochondria damage induced by hyperglycemia-driven reactive species oxygen (ROS) accumulation and verified whether mesenchymal stem cells (MSCs) anti-oxidative, anti-apoptotic, autophagy modulation, and pro-mitochondria homeostasis therapeutic potential curtailed T2DM-DKD progression.

Thu Feb 04 00:00:00 UTC 2021

Peripheral blood-derived mesenchymal stem cells demonstrate immunomodulatory potential for therapeutic use in horses.

PloS one

Longhini ALF,Salazar TE,Vieira C,Trinh T,Duan Y,Pay LM,Li Calzi S,Losh M,Johnston NA,Xie H,Kim M,Hunt RJ,Yoder MC,Santoro D,McCarrel TM,Grant MB

Published figure using CD105 monoclonal antibody (Product # MA1-80944) in Flow Cytometry

Mon Nov 25 00:00:00 UTC 2019

Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models.

Blood

Dourado KMC,Baik J,Oliveira VKP,Beltrame M,Yamamoto A,Theuer CP,Figueiredo CAV,Verneris MR,Perlingeiro RCR

MA180944 was used in flow cytometry to explore the contribution of CD105 to leukemogenesis

Thu May 04 00:00:00 UTC 2017

Targeted introduction and effective expression of hFIX at the AAVS1 locus in mesenchymal stem cells.

Molecular medicine reports

Li SJ,Luo Y,Zhang LM,Yang W,Zhang GG

MA180944 was used in flow cytometry to develop mesenchymal stem cells derivatives to treat Hemophilia B

Wed Mar 01 00:00:00 UTC 2017

Differentiation of mesenchymal stem cells from human amniotic fluid to vascular endothelial cells.

Acta histochemica

Tancharoen W,Aungsuchawan S,Pothacharoen P,Markmee R,Narakornsak S,Kieodee J,Boonma N,Tasuya W

MA180944 was used in flow cytometry to describe and differentiate human amniotic fluid mesenchymal stem cells into endothelial-like cells

Wed Mar 01 00:00:00 UTC 2017

Mesenchymal stem cells differentiated into chondrocyte-Like cells.

Acta histochemica

Narakornsak S,Poovachiranon N,Peerapapong L,Pothacharoen P,Aungsuchawan S

MA1-80944 was used in flow cytometry and immunocytochemistry to study the differentiation of chondrocyte-like cells from mesenchymal stem cells

Sun May 01 00:00:00 UTC 2016

Susceptibility of human placenta derived mesenchymal stromal/stem cells to human herpesviruses infection.

PloS one

Avanzi S,Leoni V,Rotola A,Alviano F,Solimando L,Lanzoni G,Bonsi L,Di Luca D,Marchionni C,Alvisi G,Ripalti A

MA1-80944 was used in flow cytometry to assess the susceptibility of fetal membranes-derived mesenchymal stromal/stem cells to all members of the human Herpesviridae family.

Mon Apr 14 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: CD105; CD105 antigen; Endoglin; endoglin (Osler-Rendu-Weber syndrome 1); ORW

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Gene Aliases: CD105; END; ENG; HHT1; ORW1

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UniProt ID: (Human) P17813

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Entrez Gene ID: (Human) 2022, (Horse) 100070421

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Function(s)

transmembrane signaling receptor activity transforming growth factor beta receptor, cytoplasmic mediator activity type II transforming growth factor beta receptor binding protein binding galactose binding glycosaminoglycan binding type I transforming growth factor beta receptor binding BMP binding protein homodimerization activity activin binding transforming growth factor beta binding transmembrane signal receptor

Process(es)

chronological cell aging patterning of blood vessels vasculogenesis positive regulation of protein phosphorylation heart looping sprouting angiogenesis endocardial cushion morphogenesis cardiac ventricle morphogenesis cardiac atrium morphogenesis ventricular trabecula myocardium morphogenesis cell migration involved in endocardial cushion formation regulation of transcription, DNA-templated cell adhesion negative regulation of gene expression positive regulation of pathway-restricted SMAD protein phosphorylation regulation of transforming growth factor beta receptor signaling pathway central nervous system vasculogenesis negative regulation of cell migration BMP signaling pathway positive regulation of BMP signaling pathway negative regulation of protein autophosphorylation dorsal aorta morphogenesis positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter smooth muscle tissue development artery morphogenesis venous blood vessel morphogenesis endocardial cushion to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CD105 Monoclonal Antibody (SN6), PE

CD105 Antibody (MA1-80944) in Flow

Product Details

MA1-80944

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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