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Product Details
MA5-16518
Product Specifications
Species Reactivity
Bovine,
Goat,
Human,
Sheep
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
49.1
Immunogen
The details of the immunogen for this antibody are not currently available.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein A
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2538029
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Target Information
The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ, each composed of an alpha and beta chain. The polymorphic epitope on ovine MHC class II DQ and DR molecules is constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DW2.2/DR2.2; HLA class II antigen; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA-D; HLA-DQ; HLA-DR; HLA-DRB1; human leucocyte antigen DRB1; Human leukocyte antigen DRB1; lymphocyte antigen; lymphocyte antigen DRB1; MHC Class 2; MHC class II; MHC class II antigen; MHC class II antigen DQB1; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class2 antigen; MHC DQ beta; MHC HLA-D; MHC II HLA
Gene Aliases: CELIAC1; DRB1; DRw10; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DRB; HLA-DRB1; IDDM1; SS1
UniProt ID: (Human) Q8WMA3, (Human) Q4PRC3
Entrez Gene ID: (Human) 3119, (Human) 3123
immunoglobulin production involved in immunoglobulin mediated immune response
humoral immune response mediated by circulating immunoglobulin
immune response
antigen processing and presentation of exogenous peptide antigen via MHC class II
T cell costimulation
T cell receptor signaling pathway
interferon-gamma-mediated signaling pathway
polysaccharide assembly with MHC class II protein complex
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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