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            • Primary Antibodies ›
            • CD11a Antibodies

            Invitrogen

            CD11a Monoclonal Antibody (IBL-6/2), Biotin

            View all (132) CD11a antibodies
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            Catalog # MA5-17950
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            Price (USD)
            464.00
            300 µg
             
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            Cite CD11a Monoclonal Antibody (IBL-6/2), Biotin

            Product Details

            MA5-17950

            Applications
            Tested Dilution
            Publications

            Flow Cytometry (Flow)

            Assay-dependent
            -
            Product Specifications

            Species Reactivity

            Mouse

            Host/Isotype

            Rat / IgG1

            Class

            Monoclonal

            Type

            Antibody

            Clone

            IBL-6/2

            Immunogen

            EL4 (mouse thymoma cell line)
            View immunogen

            Conjugate

            Biotin
            • Unconjugated
            • FITC
            • Request custom conjugation

            Form

            Liquid

            Concentration

            0.1 mg/mL

            Purification

            Protein G

            Storage buffer

            PBS with 4-5mg/mL BSA

            Contains

            0.02% sodium azide

            Storage conditions

            Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2539334

            Product Specific Information

            MA5-17950 targets CD11a/ITGAL/integrin alpha L in FACS applications and shows reactivity with Mouse samples.

            The MA5-17950 immunogen is eL4 (mouse thymoma cell line).

            Target Information

            CD11a (LFA-1 alpha, ITGAL) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. CD11a plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. CD11a is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of CD11a to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. CD11a is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of CD11a function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example, humanized anti- CD11a antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation, binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity. Two transcript variants encoding different isoforms of CD11a have been found. Diseases associated with CD11a dysfunction include benign cephalic histiocytosis and leukocyte adhesion deficiency.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

            References (0)

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            Cite this product

            Bioinformatics

            Protein Aliases: alpha L integrin; antigen CD11A p180; CD11 antigen-like family member A; CD11a; Integrin alpha-L; integrin alphaL; Leukocyte adhesion glycoprotein LFA-1 alpha chain; Leukocyte function-associated molecule 1 alpha chain; LFA-1A; Ly-15; Lymphocyte antigen 15; lymphocyte function associated antigen 1, alpha polypeptide

            View more View less

            Gene Aliases: (p180); Cd11a; Itgal; LFA-1; LFA-1A; Ly-15; Ly-21

            View more View less

            UniProt ID: (Mouse) P24063

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            Entrez Gene ID: (Mouse) 16408

            View more View less

            Function(s)

            ICAM-3 receptor activity protein complex binding metal ion binding protein heterodimerization activity cell adhesion molecule binding integrin

            Process(es)

            T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell-matrix adhesion signal transduction cell surface receptor signaling pathway integrin-mediated signaling pathway single organismal cell-cell adhesion regulation of cell-cell adhesion positive regulation of cell-cell adhesion positive regulation of T cell proliferation receptor clustering activated T cell proliferation positive regulation of calcium-mediated signaling
            It has to be done as per old AB suggested Products section.
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            Performance Guarantee

            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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