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Invitrogen
hnRNP C1/C2 Recombinant Rabbit Monoclonal Antibody (SN0652)
FIGURE: 1 / 14
hnRNP C1/C2 Antibody (MA5-32270) in ICC/IF
Immunofluorescence analysis of HNRNPC was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with hnRNP C1/C2 Recombinant Rabbit Monoclonal Antibody (SN0652) (Product # MA5-32270) at 1:100 dilution in 0.1% BSA, inc... View More
Product Details
MA5-32270
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
SN0652
Immunogen
Recombinant protein of Human HNRNPC aa 60-190
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2809556
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
Target Information
The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. hnRNP C1 and C2 are encoded by one gene; the two alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterogeneous nuclear ribonucleoprotein C; heterogeneous nuclear ribonucleoprotein C (C1/C2); heterogeneous nuclear ribonucleoprotein C1; heterogeneous nuclear ribonucleoprotein C2; Heterogeneous nuclear ribonucleoproteins C1/C2; heterogeneous ribonucleoprotein C1/C2; hnRNP C protein C-terminal fragment (158 AA); hnRNP C1 / hnRNP C2; hnRNP C1/C2; hnRNP C2; hnRNP core protein C; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein; snoRNA MBI-122
Gene Aliases: AL022939; bZ1G18.4; C1; C2; D14Wsu171e; fb57h12; fi16b11; HNRNP; hnRNP C; hnrnp-C; HNRNPC; hnRNPC1; hnRNPC2; HNRPC; Hnrpc1; Hnrpc2; SNRPC; wu:fb57h12; wu:fi16b11; zgc:55701
UniProt ID: (Human) P07910, (Mouse) Q9Z204
Entrez Gene ID: (Human) 3183, (Rat) 290046, (Mouse) 15381, (Zebrafish) 406352
nucleotide binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA binding
mRNA 3'-UTR binding
protein binding
poly(U) RNA binding
nucleosomal DNA binding
identical protein binding
poly(A) RNA binding
telomerase RNA binding
N6-methyladenosine-containing RNA binding
nucleic acid binding
mRNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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