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Invitrogen

ADAMTS5 Polyclonal Antibody

Advanced Verification

6 Published Figures

4 References

View all (9) ADAMTS5 antibodies

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Catalog # PA5-14350

Price (KRW)

596,000

온라인 행사

Ends: 30-Jun-2025

701,000

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400 µL

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Datasheet

Protocols

Questions & Answers

Tech Support

Application

FIGURE: 1 / 8

ADAMTS5 Antibody (PA5-14350) in WB

Western blot analysis of ADAMTS5 in mouse muscle tissue lysates. Samples were incubated with ADAMTS5 polyclonal antibody (Product # PA5-14350). Lysates: 35 µg/lane. ADAMTS5(arrow).

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Product Details

PA5-14350

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide between 331-360 amino acids from the central region of human ADAMTS5

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A, Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_11005168

Target Information

ADAMTS5, also known as Implantin or Aggrecanase 2, is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS5 (A Disintegrin And Metalloproteinase with Thrombospondin-5 motif) was first described as ADAMTS5, a protein elevated in mice during the peri-implantion period. At the same time, another group identified Aggrecanase 11, a protein elevated in arthritic synovium. The name was later changed to ADAMTS5. ADAMTS5 is expressed in human and mouse. It has been found in heart, lung, cervix, uterus, ovary, brain, cartilage, and numerous other tissues, as well as chondroblastoma cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation.

Heliyon

He A,Liu Y,Zhang R,Mao Y,Liu W

Published figure using ADAMTS5 polyclonal antibody (Product # PA5-14350) in Western Blot

Thu Jun 01 00:00:00 UTC 2023

Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578.

Cell death discovery

Yan P,Sun C,Luan L,Han J,Qu Y,Zhou C,Xu D

PA5-14350 was used in Western Blot to suggest that circ_0134111 could promote the progression of IDD through enhancing aberrant NP cell growth, inflammation, and ECM degradation partly via regulating miR-578.

Tue Feb 08 00:00:00 UTC 2022

Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578.

Cell death discovery

Yan P,Sun C,Luan L,Han J,Qu Y,Zhou C,Xu D

Tue Feb 08 00:00:00 UTC 2022

Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth.

The Journal of biological chemistry

Niu N,Shao R,Yan G,Zou W

PA514350 was used in western blot to demonstrate that inhibition of bromodomain and extra-terminal proteins suppresses chondrocyte differentiation and restrains bone growth

Fri Dec 23 00:00:00 UTC 2016

Bromodomain and Extra-terminal (BET) Protein Inhibitors Suppress Chondrocyte Differentiation and Restrain Bone Growth.

The Journal of biological chemistry

Niu N,Shao R,Yan G,Zou W

PA514350 was used in western blot to demonstrate that inhibition of bromodomain and extra-terminal proteins suppresses chondrocyte differentiation and restrains bone growth

Fri Dec 23 00:00:00 UTC 2016

Matrix cross-linking-mediated mechanotransduction promotes posttraumatic osteoarthritis.

Proceedings of the National Academy of Sciences of the United States of America

Kim JH,Lee G,Won Y,Lee M,Kwak JS,Chun CH,Chun JS

PA5-14350 was used in western blot to assess the role of matrix-mediated mechanotransduction in osteoarthritis pathogenesis

Tue Jul 28 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2); ADAM; ADAM-TS 11; ADAM-TS 5; ADAMs; ADAMTS-5; ADMP-2; Aggrecanase 2; Aggrecanase-2; Implantin; metalloendopeptidases

Gene Aliases: 9530092O11Rik; ADAM-TS 11; ADAM-TS 5; ADAM-TS5; ADAMTS-11; ADAMTS-5; ADAMTS1; ADAMTS11; ADAMTS5; ADMP-2; ADMP2; AI481094; ASMP-2

UniProt ID: (Human) Q9UNA0, (Mouse) Q9R001

Entrez Gene ID: (Human) 11096, (Mouse) 23794

Function(s)

metalloendopeptidase activity integrin binding protein binding heparin binding metallopeptidase activity zinc ion binding extracellular matrix binding peptidase activity hydrolase activity metal ion binding metalloprotease

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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