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Invitrogen
Syntenin 1 Polyclonal Antibody
FIGURE: 1 / 5
Syntenin 1 Antibody (PA5-18595) in IHC (P)
Immunohistochemistry analysis of Syntenin 1 in human breast. Samples were incubated with Syntenin 1 polyclonal antibody (Product # PA5-18595) using a dilution of 10 µg/mL. Formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Product Details
PA5-18595
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (SLEDLKVDKVIQAQ) corresponding to the N-terminus amino acids of SDCBP (aa 6-20).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_10985187
Product Specific Information
This antibody is predicted to react with canine, mouse and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 128,000.
Target Information
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; syndecan binding protein (syntenin); Syndecan-binding protein 1; Syntenin-1; TACIP18
Gene Aliases: MDA-9; MDA9; SDCBP; ST1; SYCL; TACIP18
UniProt ID: (Human) O00560
Entrez Gene ID: (Human) 6386
glycoprotein binding
frizzled binding
interleukin-5 receptor binding
protein binding
protein C-terminus binding
cytoskeletal adaptor activity
growth factor binding
neurexin family protein binding
identical protein binding
protein homodimerization activity
syndecan binding
ephrin receptor binding
protein heterodimerization activity
protein N-terminus binding
cadherin binding involved in cell-cell adhesion
membrane trafficking regulatory protein
negative regulation of receptor internalization
protein targeting to membrane
substrate-dependent cell migration, cell extension
Ras protein signal transduction
chemical synaptic transmission
regulation of mitotic cell cycle
positive regulation of cell proliferation
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
actin cytoskeleton organization
positive regulation of cell growth
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
intracellular signal transduction
positive regulation of phosphorylation
positive regulation of JNK cascade
ephrin receptor signaling pathway
cell-cell adhesion
positive regulation of exosomal secretion
positive regulation of extracellular exosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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