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SCN1B Antibody (PA5-24142) in IHC (P)
Immunohistochemistry analysis of SCN1B in formalin fixed and paraffin embedded human brain tissue. Samples were incubated with SCN1B polyclonal antibody (Product # PA5-24142) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-24142
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2541642
Product Specific Information
This antibody is predicted to react with bovine, rat and rabbit based on sequence homology.
Target Information
Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Sodium channel regulatory subunit beta-1; sodium channel subunit beta-1; sodium channel, voltage gated, type I beta subunit; sodium channel, voltage-gated, type I, beta; sodium channel, voltage-gated, type I, beta polypeptide
Gene Aliases: ATFB13; BRGDA5; GEFSP1; SCN1B
UniProt ID: (Human) Q07699, (Mouse) P97952
Entrez Gene ID: (Human) 6324, (Mouse) 20266
voltage-gated sodium channel activity
protein binding
sodium channel regulator activity
sodium channel inhibitor activity
voltage-gated sodium channel activity involved in cardiac muscle cell action potential
voltage-gated sodium channel activity involved in Purkinje myocyte action potential
voltage-gated ion channel activity
sodium channel activity
ion channel
transporter
voltage-gated ion channel
cell adhesion
chemical synaptic transmission
axon guidance
positive regulation of sodium ion transport
positive regulation of neuron projection development
neuronal action potential propagation
corticospinal neuron axon guidance
sodium ion transmembrane transport
locomotion
response to pyrethroid
membrane depolarization
cardiac muscle contraction
regulation of postsynaptic membrane potential
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of atrial cardiac muscle cell membrane depolarization
cardiac conduction
cardiac muscle cell action potential involved in contraction
membrane depolarization during cardiac muscle cell action potential
membrane depolarization during Purkinje myocyte cell action potential
regulation of heart rate by cardiac conduction
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transport
transport
ion transport
sodium ion transport
regulation of ion transmembrane transport
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