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Application
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CHRNA4 (extracellular) Antibody (PA5-77502) in IHC (F)
Immunohistochemistry analysis of CHRNA4 (extracellular) in perfusion-fixed, frozen mouse brain. A) Samples were probed with CHRNA4 (extracellular) polyclonal antibody (Product # PA5-77502) using a dilution of 1:300 (green), and incubated with fluorescent 594 and DAPI. B) Parietal cortex stained image (red). C) Merged image of Panels A and B.
Product Details
PA5-77502
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)DLVNMHSRVDQLD, corresponding to amino acid residues 190-202 of human nAChRalpha4
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2735650
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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