Troponin I Antibodies

Target Information

Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes.

Synonyms

2700018B22Rik; AI747285; Cardiac troponin I; cardiomyopathy, dilated 2A (autosomal recessive); CMD1FF; CMD2A; CMH7; cTNI; DKFZp451O223; RCM1; slow skeletal troponin I isoform; ssTnI; Tn1; TnI; TNN1; TNNC1; TNNI1; TNNI3; Tpn1; troponin 1, type 3; troponin I type 1 (skeletal, slow); troponin I type 3 (cardiac); troponin I, cardiac 3; troponin I, cardiac muscle; troponin I, skeletal, slow; troponin I, skeletal, slow 1; Troponin I, slow isoform; troponin I, slow skeletal; troponin I, slow skeletal muscle; Troponin I, slow-twitch isoform; troponin I1, slow skeletal type; troponin I3, cardiac type