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This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.
a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 8; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif 8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; ADAMs; ADAM-TS 8; ADAMTS8; ADAM-TS8; ADAMTS-8; ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2); EC 3.4.24.14; EC 3.4.24.82; FLJ41712; metalloendopeptidases; METH2; METH-2; METH2ADAM-TS METH-8; METH-8
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