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The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This encoded protein, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
2700007F14Rik; acetaldehyde dehydrogenase 5; ADH, beta subunit; ADH1B; ADH2; alcohol dehydrogenase 1B; alcohol dehydrogenase 1B (class I), beta polypeptide; alcohol dehydrogenase 2 (class I), beta polypeptide; alcohol dehydrogenase subunit beta; aldehyde dehydrogenase 1 family member B1; aldehyde dehydrogenase 1 family, member B1; aldehyde dehydrogenase 1B1; aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; aldehyde dehydrogenase X, mitochondrial; aldehyde reductase; ALDH class 2; Aldh1b1; ALDH5; Aldhx; All-trans-retinol dehydrogenase [NAD(+)] ADH1B; epididymis secretory protein Li 117; HEL-S-117
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