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This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
inositol 1,4,5-triphosphate receptor 3; inositol 1,4,5-triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; inositol 1,4,5-trisphosphate receptor, type 3; insP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R; IP3R 3; Ip3r3; IP3R-3; IP3R3X; ITPR3; Itpr-3; Type 3 inositol 1,4,5-trisphosphate receptor; type 3 InsP3 receptor
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