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The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. The protein encoded by this gene is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. Mutations in this gene are associated with several neurological and cognitive disorders. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
1500010O20Rik; 2900036G11Rik; Kiaa1867; kin of IRRE like 3 (Drosophila); Kin of irregular chiasm-like protein 3; kin of IRRE-like protein 3; KIRRE; KIRREL3; membrane protein mKirre; mKIAA1867; mKirre; MRD4; NEPH2; nephrin-like 2; nephrin-like protein 2; PRO4502; Processed kin of IRRE-like protein 3; SST4; UNQ5923/PRO4502/PRO19814; X kin of IRRE like 3
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