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This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
4833426I20Rik; FLJ21889; Loxc; LOXL4; Lysyl oxidase homolog 4; lysyl oxidase like 4; lysyl oxidase related C; lysyl oxidase-like 4; lysyl oxidase-like 4 pseudogene; lysyl oxidase-like protein 4; Lysyl oxidase-related protein C
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