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This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
AI644666; AW743257; D930008C07Rik; FLJ53540; KIAA0200; Mam1; Mam-1; MAML1; mastermind homolog; mastermind like 1 (Drosophila); mastermind like transcriptional coactivator 1; mastermind-like 1; mastermind-like protein 1; mastermind-like transcriptional coactivator 1; mKIAA0200
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