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The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku, which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties.
A730013B20Rik; mitochondrial tRNA pseudouridine synthase A; MLASA1; MNCb-0873; MPUS1; mPus1p; PP8985; pseudouridine synthase 1; pseudouridylate synthase 1; Pus1; pus1 {ECO:0000312; RGD:1311871}; tRNA pseudouridine synthase A; tRNA pseudouridine synthase A, mitochondrial; tRNA pseudouridine(38-40) synthase; tRNA pseudouridylate synthase I; tRNA uridine isomerase I; tRNA-uridine isomerase I
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