Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
ADD1; ADD-1; Adipocyte determination- and differentiation-dependent factor 1; AI608257; bHLHd1; BHLHD2; class D basic helix-loop-helix protein 1; Class D basic helix-loop-helix protein 2; D630008H06; EMBL:AAI01903.1}; lop13; nuc; Processed sterol regulatory element-binding protein 1; Processed sterol regulatory element-binding protein 2; Srebf1; SREBF2; srebf2 {ECO:0000312; Srebf2_retired; SREBP1; SREBP-1; SREBP1a; SREBP-1a; SREBP1c; SREBP-1c; Srebp2; SREBP-2; SREBP2gc; sterol regulatory element binding factor 2; sterol regulatory element binding protein 2; sterol regulatory element binding transcription factor 1; sterol regulatory element binding transcription factor 2; sterol regulatory element-binding protein 1; Sterol regulatory element-binding protein 2; Sterol regulatory element-binding transcription factor 1; Sterol regulatory element-binding transcription factor 2
100 µL
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk to a specialist nowIf an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support