Syntrophin 1/2/3 Antibodies

Target Information

Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. This gene is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. This gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue. [provided by RefSeq, Jan 2013].

Synonyms

59 kDa dystrophin-associated protein A1 acidic component 1; 59 kDa dystrophin-associated protein A1 basic component 1; 59 kDa dystrophin-associated protein A1 basic component 2; 59-1 DAP; 59-DAP; A1B; acidic alpha 1 syntrophin; alpha-1-syntrophin; alpha1-syntrophin; AW228934; Beta-1-syntrophin; beta1-Syntrophin; beta-2-syntrophin; BSYN2; D16S2531E; DAPA1B; dJ1187J4.5; dystrophin-associated protein A1, 59kD, basic component 1; dystrophin-associated protein A1, 59kD, basic component 2; dystrophin-associated protein A1, 59kDa, acidic component; EST25263; LQT12; Pro-TGF-alpha cytoplasmic domain-interacting protein 1; SNT1; SNT2; SNT2B1; Snt2b2; SNT3; SNTA1; Sntb1; SNTB2; SNTL; syntrophin alpha 1; syntrophin beta 1; syntrophin beta 2; syntrophin, acidic 1; syntrophin, alpha 1; syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component); syntrophin, basic 1; syntrophin, basic 2; syntrophin, beta 1; syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1); syntrophin, beta 2; syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2); syntrophin-1; Syntrophin-2; syntrophin-3; Syntrophin-like; TACIP1; Tax interaction protein 43; TIP-43