TIA1/TIAL1 Antibodies

Target Information

TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Diseases associated with TIAL1 include Salpingitis Isthmica Nodosa and Spinal Muscular Atrophy. Among its related pathways are Signaling by GPCR and Chromatin Regulation / Acetylation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1. The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

Synonyms

2310050N03Rik; 5330433G13Rik; aging-associated gene 7 protein; AI256674; AL033329; cytotoxic granule-associated RNA binding protein 1; cytotoxic granule-associated RNA-binding protein 1; MGC33401; mTIA-1; mTIAR; Nucleolysin TIA-1; nucleolysin TIA-1 isoform p40; Nucleolysin TIAR; OTTHUMP00000020602; OTTHUMP00000020605; p40-TIA-1; p40-TIA-1 (containing p15-TIA-1); RNA binding protein TIAR (TIA-1 related); RNA-binding protein TIA-1; TCBP; T-cell-restricted intracellular antigen-1; T-cluster binding protein; Tia; Tia1; TIA-1; TIA1 cytotoxic granule-associated RNA binding protein; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA-1-related nucleolysin; TIA-1-related protein; Tial 1 cytotoxic granule-associated RNA- binding protein-like 1; TIAL1; Tial1 cytotoxic granule-associated RNA binding protein-like 1; Tial1 cytotoxic granule-associated RNA-binding protein-like 1; TIAR; WDM