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Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
C230057C06Rik; E(Sp1) homolog; enhancer of split groucho; enhancer of split groucho-like protein 1; esg; ESG1; Estm14; grg1; Grg-1; Groucho-related protein 1; RP11-203D19.1; TLE 1; TLE1; tle1.S; tle3b; Tle4l; transducin like enhancer of split 1; transducin like enhancer of split 1 S homeolog; transducin-like enhancer of split 1 (E(sp1) homolog); transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 1, homolog of Drosophila E(spl); transducin-like enhancer of split 3 (E(sp1) homolog) b; transducin-like enhancer of split 4 (homolog of Drosophila E(spl)) - like; transducin-like enhancer protein 1; XELAEV_18001139mg; xgrg1
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