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USP6 is a deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. It catalyzes its own deubiquitination. In vitro, isoform2, but not isoform3, shows deubiquitinating activity. USP6 promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. It is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Deubiquitinating enzyme 6; HRP1; hyperpolymorphic gene 1; proto-oncogene TRE-2; TBC1D3 and USP32 fusion; TRE17; TRE2; Tre-2; TRESMCR; Ubiquitin carboxyl-terminal hydrolase 6; ubiquitin specific peptidase 6; ubiquitin specific peptidase 6 (Tre-2 oncogene); ubiquitin specific protease 6 (Tre-2 oncogene); ubiquitin thioesterase 6; ubiquitin thiolesterase 6; ubiquitin-specific protease USP6; ubiquitin-specific-processing protease 6; USP6; USP6-short
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