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Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex (PubMed:15824131). [UniProt]
2310031L18Rik; homolog of Drosophila Zwilch; hZwilch; KNTC1AP; protein zwilch homolog; ZWILCH; zwilch kinetochore protein; Zwilch, kinetochore associated, homolog
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100 µg
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100 µL
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