Product References
BRAF D594A mutation defines a unique biological and immuno-modulatory subgroup associated with functional CD8+ T cell infiltration in colorectal cancer.
Journal of translational medicine
Li W,Zhao C,Li W,Gong Y,Ma K,Lu Y,Liu X,Zhang L,Guo F
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2023
Extracellular acidosis restricts one-carbon metabolism and preserves T cell stemness.
Nature metabolism
Cheng H,Qiu Y,Xu Y,Chen L,Ma K,Tao M,Frankiw L,Yin H,Xie E,Pan X,Du J,Wang Z,Zhu W,Chen L,Zhang L,Li G
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2023
TIM3 Expression in Anaplastic-Thyroid-Cancer-Infiltrating Macrophages: An Emerging Immunotherapeutic Target.
Biology
Palacios LM,Peyret V,Viano ME,Geysels RC,Chocobar YA,Volpini X,Pellizas CG,Nicola JP,Motran CC,Rodriguez-Galan MC,Fozzatti L
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Thu Nov 03 00:00:00 EDT 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion.
iScience
Ma K,Sun L,Shen M,Zhang X,Xiao Z,Wang J,Liu X,Jiang K,Xiao-Feng Qin F,Guo F,Zhang B,Zhang L
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Fri May 20 00:00:00 EDT 2022
Mobilizing phospholipids on tumor plasma membrane implicates phosphatidylserine externalization blockade for cancer immunotherapy.
Cell reports
Wang W,Wu S,Cen Z,Zhang Y,Chen Y,Huang Y,Cillo AR,Prokopec JS,Quarato G,Vignali DAA,Stewart-Ornstein J,Li S,Lu B,Gong YN
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Tue Nov 01 00:00:00 EDT 2022
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.
Nature communications
Sun Y,Lu D,Yin Y,Song J,Liu Y,Hao W,Qi F,Zhang G,Zhang X,Liu L,Lin Z,Liang H,Zhao X,Jin Y,Yin Y
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Thu Aug 26 00:00:00 EDT 2021
A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy.
The Journal of experimental medicine
Oda SK,Anderson KG,Ravikumar P,Bonson P,Garcia NM,Jenkins CM,Zhuang S,Daman AW,Chiu EY,Bates BM,Greenberg PD
14-5870-82 was used in Flow Cytometry to develop enhanced adoptive T cell therapy using immunomodulatory fusion proteins for use in solid tumours.
Mon Dec 07 00:00:00 EST 2020
Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer.
Therapeutic advances in medical oncology
Doo DW,Meza-Perez S,Londoño AI,Goldsberry WN,Katre AA,Boone JD,Moore DJ,Hudson CT,Betella I,McCaw TR,Gangrade A,Bao R,Luke JJ,Yang ES,Birrer MJ,Starenki D,Cooper SJ,Buchsbaum DJ,Norian LA,Randall TD,Arend RC
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Thu Apr 14 00:00:00 EDT 2022
Mechanisms of action of ruxolitinib in murine models of hemophagocytic lymphohistiocytosis.
Blood
Albeituni S,Verbist KC,Tedrick PE,Tillman H,Picarsic J,Bassett R,Nichols KE
14-5870-82 was used in Flow Cytometry to show that ruxolitinib operates through IFN-γ-dependent and -independent mechanisms to dampen HLH by targeting the deleterious effects of T cells and neutrophils, with the latter representing an unappreciated and understudied cell type that contributes to HLH pathogenesis.
Thu Jul 11 00:00:00 EDT 2019
Mapping the Lineage Relationship between CXCR5+ and CXCR5- CD4+ T Cells in HIV-Infected Human Lymph Nodes.
Cell reports
Del Alcazar D,Wang Y,He C,Wendel BS,Del Río-Estrada PM,Lin J,Ablanedo-Terrazas Y,Malone MJ,Hernandez SM,Frank I,Naji A,Reyes-Terán G,Jiang N,Su LF
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Tue Sep 17 00:00:00 EDT 2019
Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
Frontiers in microbiology
Hou N,Jiang N,Zou Y,Piao X,Liu S,Li S,Chen Q
14-5870 was used in Functional assays to investigate the mechanisms of Tim-3 mediated responses in monocytes and macrophages in malaria.
Wed Sep 30 00:00:00 EDT 2020
Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
Frontiers in microbiology
Hou N,Jiang N,Zou Y,Piao X,Liu S,Li S,Chen Q
14-5870 was used in Functional assays to investigate the mechanisms of Tim-3 mediated responses in monocytes and macrophages in malaria.
Wed Sep 30 00:00:00 EDT 2020
Down-Regulation of Tim-3 in Monocytes and Macrophages in Plasmodium Infection and Its Association with Parasite Clearance.
Frontiers in microbiology
Hou N,Jiang N,Zou Y,Piao X,Liu S,Li S,Chen Q
14-5870 was used in Functional assays to investigate the mechanisms of Tim-3 mediated responses in monocytes and macrophages in malaria.
Wed Sep 30 00:00:00 EDT 2020
T-Cell Immunoglobulin- and Mucin-Domain-Containing Molecule 3 Signaling Blockade Improves Cell-Mediated Immunity Against Malaria.
The Journal of infectious diseases
Hou N,Zou Y,Piao X,Liu S,Wang L,Li S,Chen Q
14-5870 was used in Flow cytometry/Cell sorting to determine the role of upregulated Tim-3 in cell mediated immune regulation against Plasmodium infection.
Tue Nov 15 00:00:00 EST 2016
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression.
Oncoimmunology
Chen L,Yi X,Goswami S,Ahn YH,Roybal JD,Yang Y,Diao L,Peng D,Peng D,Fradette JJ,Wang J,Byers LA,Kurie JM,Ullrich SE,Qin FX,Gibbons DL
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection.
Infection and immunity
Hou N,Piao X,Liu S,Wu C,Chen Q
14-5870 was used in Functional assays to investigate the role of Tim-3 in the immune response against S. japonicum infection.
Sat Aug 01 00:00:00 EDT 2015
Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection.
Infection and immunity
Hou N,Piao X,Liu S,Wu C,Chen Q
14-5870 was used in Functional assays to investigate the role of Tim-3 in the immune response against S. japonicum infection.
Sat Aug 01 00:00:00 EDT 2015
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma.
Journal for immunotherapy of cancer
Jing W,Gershan JA,Weber J,Tlomak D,McOlash L,Sabatos-Peyton C,Johnson BD
14587082 was used in flow cytometry to test if blocking several checkpoint receptors boosts anti-tumor immunity in a low-dose, lymphodepleting whole body radiation model
Fri Jan 23 00:00:00 EST 2015
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression.
Nature communications
Chen L,Gibbons DL,Goswami S,Cortez MA,Ahn YH,Byers LA,Zhang X,Yi X,Dwyer D,Lin W,Diao L,Wang J,Roybal J,Patel M,Ungewiss C,Peng D,Antonia S,Mediavilla-Varela M,Robertson G,Suraokar M,Welsh JW,Erez B,Wistuba II,Chen L,Peng D,Wang S,Ullrich SE,Heymach JV,Kurie JM,Qin FX
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Tue Oct 28 00:00:00 EDT 2014
T cell Ig mucin-3 promotes homeostasis of sepsis by negatively regulating the TLR response.
Journal of immunology (Baltimore, Md. : 1950)
Yang X,Jiang X,Chen G,Xiao Y,Geng S,Kang C,Zhou T,Li Y,Guo X,Xiao H,Hou C,Wang R,Lin Z,Li X,Feng J,Ma Y,Shen B,Li Y,Han G
14-5870 was used in Western Blotting to demonstrate a regulatory role for Tim-3 as part of a novel protective mechanism in sepsis victims.
Fri Mar 01 00:00:00 EST 2013
The influence of T cell Ig mucin-3 signaling on central nervous system autoimmune disease is determined by the effector function of the pathogenic T cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SY,Goverman JM
14-5870 was used in Flow cytometry/Cell sorting to analyse the role of Tim-3 signalling within various innate immune cells on the development of experimental autoimmune encephalomyelitis.
Wed May 15 00:00:00 EDT 2013
Transcutaneous vaccination via laser microporation.
Journal of controlled release : official journal of the Controlled Release Society
Weiss R,Hessenberger M,Kitzmüller S,Bach D,Weinberger EE,Krautgartner WD,Hauser-Kronberger C,Malissen B,Boehler C,Kalia YN,Thalhamer J,Scheiblhofer S
14-5870 was used in Flow cytometry/Cell sorting to investigate the potential of transcutaneous immunisation via laser-generated micropores for induction of specific immune responses.
Mon Sep 10 00:00:00 EDT 2012
CD8 T cells recruited early in mouse polyomavirus infection undergo exhaustion.
Journal of immunology (Baltimore, Md. : 1950)
Wilson JJ,Pack CD,Lin E,Frost EL,Albrecht JA,Hadley A,Hofstetter AR,Tevethia SS,Schell TD,Lukacher AE
14-5870 was used in Flow cytometry/Cell sorting to characterise virus-specific CD8 T cells recruited during persistent infection.
Tue May 01 00:00:00 EDT 2012
Exposure to nicotine adversely affects the dendritic cell system and compromises host response to vaccination.
Journal of immunology (Baltimore, Md. : 1950)
Nouri-Shirazi M,Guinet E
14-5870 was used in Flow cytometry/Cell sorting to investigate the causal relationship between nicotine-induced dendritic cell alterations and host response to vaccines.
Thu Mar 01 00:00:00 EST 2012
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression.
PloS one
Gao X,Zhu Y,Li G,Huang H,Zhang G,Wang F,Sun J,Yang Q,Zhang X,Lu B
14-5870 was used in Flow cytometry/Cell sorting to reveal a new role for TIM-3 as an important immune regulator in the tumour microenvironment.
Fri Jun 29 00:00:00 EDT 2012
T lymphocyte surface expression of exhaustion markers as biomarkers of the efficacy of chemotherapy for tuberculosis.
Tuberculosis (Edinburgh, Scotland)
Henao-Tamayo M,Irwin SM,Shang S,Ordway D,Orme IM
14-5870 was used in Flow cytometry/Cell sorting to identify that surface expression of PD-1, TIM-3 and KLRG-1 on T-lymphocytes changed with reduction of bacterial load in the lungs.
Fri Jul 01 00:00:00 EDT 2011
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.
Blood
Nakayama M,Akiba H,Takeda K,Kojima Y,Hashiguchi M,Azuma M,Yagita H,Okumura K
Thu Apr 16 00:00:00 EDT 2009
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation.
Blood
Nakayama M,Akiba H,Takeda K,Kojima Y,Hashiguchi M,Azuma M,Yagita H,Okumura K
Thu Apr 16 00:00:00 EDT 2009
Phenotypic switching in Cryptococcus neoformans contributes to virulence by changing the immunological host response.
Infection and immunity
Guerrero A,Fries BC
Published figure using CD366 (TIM3) monoclonal antibody (Product # 14-5870-82) in Flow Cytometry
Mon Sep 01 00:00:00 EDT 2008