Product References
T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis.
Immunity
Briukhovetska D,Suarez-Gosalvez J,Voigt C,Markota A,Giannou AD,Schübel M,Jobst J,Zhang T,Dörr J,Märkl F,Majed L,Müller PJ,May P,Gottschlich A,Tokarew N,Lücke J,Oner A,Schwerdtfeger M,Andreu-Sanz D,Grünmeier R,Seifert M,Michaelides S,Hristov M,König LM,Cadilha BL,Mikhaylov O,Anders HJ,Rothenfusser S,Flavell RA,Cerezo-Wallis D,Tejedo C,Soengas MS,Bald T,Huber S,Endres S,Kobold S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jan 10 00:00:00 EST 2023
Biometabolites of Citrus unshiu Peel Enhance Intestinal Permeability and Alter Gut Commensal Bacteria.
Nutrients
Lee SH,Seo D,Lee KH,Park SJ,Park S,Kim H,Kim T,Joo IH,Park JM,Kang YH,Lim GH,Kim DH,Yang JY
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jan 09 00:00:00 EST 2023
Klebsiella pneumoniae Induces Inflammatory Bowel Disease Through Caspase-11-Mediated IL18 in the Gut Epithelial Cells.
Cellular and molecular gastroenterology and hepatology
Zhang Q,Su X,Zhang C,Chen W,Wang Y,Yang X,Liu D,Zhang Y,Yang R
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Feb 23 00:00:00 EST 2023
Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.
Biomaterials
Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2023
Histone methyltransferase WHSC1 loss dampens MHC-I antigen presentation pathway to impair IFN-γ-stimulated antitumor immunity.
The Journal of clinical investigation
Ren J,Li N,Pei S,Lian Y,Li L,Peng Y,Liu Q,Guo J,Wang X,Han Y,Zhang G,Wang H,Li Y,Jiang J,Li Q,Tan M,Peng J,Hu G,Xiao Y,Li X,Lin M,Qin J
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Apr 15 00:00:00 EDT 2022
A peptide encoded by pri-miRNA-31 represses autoimmunity by promoting Treg differentiation.
EMBO reports
Zhou H,Lou F,Bai J,Sun Y,Cai W,Sun L,Xu Z,Liu Z,Zhang L,Yin Q,Zhang J,Gao Y,Wang Z,Niu L,Cai X,Deng S,Wang H,Xia L,Ginhoux F,Li Q,Wang H
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed May 04 00:00:00 EDT 2022
Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases.
Arthritis research & therapy
Chen YH,Liu RH,Cui YZ,Hettinghouse A,Fu WY,Zhang L,Zhang C,Liu CJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Jan 19 00:00:00 EST 2022
Neutrophil extracellular traps and their histones promote Th17 cell differentiation directly via TLR2.
Nature communications
Wilson AS,Randall KL,Pettitt JA,Ellyard JI,Blumenthal A,Enders A,Quah BJ,Bopp T,Parish CR,Brüstle A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Jan 26 00:00:00 EST 2022
Forsythiaside A Improves the Inhibitory Efficiency of Recombinant Protein Vaccines against Bovine Viral Diarrhea Virus Infection.
International journal of molecular sciences
Yang G,Wang J,Wang S,Zhu Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat Aug 20 00:00:00 EDT 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Aug 22 00:00:00 EDT 2022
Leishmania donovani Impedes Antileishmanial Immunity by Suppressing Dendritic Cells via the TIM-3 Receptor.
mBio
Akhtar MN,Kumar S,Sen P
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Aug 30 00:00:00 EDT 2022
Agr2-associated ER stress promotes adherent-invasive E. coli dysbiosis and triggers CD103+ dendritic cell IL-23-dependent ileocolitis.
Cell reports
Viladomiu M,Khounlotham M,Dogan B,Lima SF,Elsaadi A,Cardakli E,Castellanos JG,Ng C,Herzog J,Schoenborn AA,Ellermann M,Liu B,Zhang S,Gulati AS,Sartor RB,Simpson KW,Lipkin SM,Longman RS
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2022
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression.
Nature communications
Qi M,Xia Y,Wu Y,Zhang Z,Wang X,Lu L,Dai C,Song Y,Xu K,Ji W,Zhan L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Feb 16 00:00:00 EST 2022
Breast cancer cell-derived extracellular vesicles promote CD8+ T cell exhaustion via TGF-β type II receptor signaling.
Nature communications
Xie F,Zhou X,Su P,Li H,Tu Y,Du J,Pan C,Wei X,Zheng M,Jin K,Miao L,Wang C,Meng X,van Dam H,Ten Dijke P,Zhang L,Zhou F
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2022
Local and Systemic Injections of Human Cord Blood Myeloid-Derived Suppressor Cells to Prevent Graft Rejection in Corneal Transplantation.
Biomedicines
Lee JY,Sohn HJ,Kim CH,Kim TG,Lee HS
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Dec 12 00:00:00 EST 2022
Transcription factor RORα enforces stability of the Th17 cell effector program by binding to a Rorc cis-regulatory element.
Immunity
Hall JA,Pokrovskii M,Kroehling L,Kim BR,Kim SY,Wu L,Lee JY,Littman DR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Nov 08 00:00:00 EST 2022
Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells.
EMBO reports
Lopez Krol A,Nehring HP,Krause FF,Wempe A,Raifer H,Nist A,Stiewe T,Bertrams W,Schmeck B,Luu M,Leister H,Chung HR,Bauer UM,Adhikary T,Visekruna A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Dec 06 00:00:00 EST 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Jul 08 00:00:00 EDT 2021
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice.
Immunity
Shreeve N,Depierreux D,Hawkes D,Traherne JA,Sovio U,Huhn O,Jayaraman J,Horowitz A,Ghadially H,Perry JRB,Moffett A,Sled JG,Sharkey AM,Colucci F
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jun 08 00:00:00 EDT 2021
The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13.
Cellular & molecular immunology
Mulas F,Wang X,Song S,Nishanth G,Yi W,Brunn A,Larsen PK,Isermann B,Kalinke U,Barragan A,Naumann M,Deckert M,Schlüter D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Ma C,Li S,Hu Y,Ma Y,Wu Y,Wu C,Liu X,Wang B,Hu G,Zhou J,Yang S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon May 03 00:00:00 EDT 2021
Mapping and role of T cell response in SARS-CoV-2-infected mice.
The Journal of experimental medicine
Zhuang Z,Lai X,Sun J,Chen Z,Zhang Z,Dai J,Liu D,Li Y,Li F,Wang Y,Zhu A,Wang J,Yang W,Huang J,Li X,Hu L,Wen L,Zhuo J,Zhang Y,Chen D,Li S,Huang S,Shi Y,Zheng K,Zhong N,Zhao J,Zhou D,Zhao J
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Low immunogenicity of malaria pre-erythrocytic stages can be overcome by vaccination.
EMBO molecular medicine
Müller K,Gibbins MP,Roberts M,Reyes-Sandoval A,Hill AVS,Draper SJ,Matuschewski K,Silvie O,Hafalla JCR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Apr 09 00:00:00 EDT 2021
High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.
Frontiers in cell and developmental biology
Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Apr 13 00:00:00 EDT 2021
Senescent T Cell Induces Brown Adipose Tissue "Whitening" Via Secreting IFN-γ.
Frontiers in cell and developmental biology
Pan XX,Yao KL,Yang YF,Ge Q,Zhang R,Gao PJ,Ruan CC,Wu F
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
Trichinella spiralis Paramyosin Induces Colonic Regulatory T Cells to Mitigate Inflammatory Bowel Disease.
Frontiers in cell and developmental biology
Hao C,Wang W,Zhan B,Wang Z,Huang J,Sun X,Zhu X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
SZB120 Exhibits Immunomodulatory Effects by Targeting eIF2α to Suppress Th17 Cell Differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Chen L,Bai J,Peng D,Gao Y,Cai X,Zhang J,Tang S,Niu L,Sun Y,Lou F,Zhou H,Yin Q,Wang Z,Sun L,Du X,Xu Z,Wang H,Li Q,Wang H
14-7311-81 was used in Flow Cytometry to characterise the target and mechanism of an acetylated beta-boswellic acid derivative termed SZB120, and evaluate the anti-inflammatory activities in vitro and in vivo.
Mon Mar 01 00:00:00 EST 2021
Prevention of EAE by tolerogenic vaccination with PEGylated antigenic peptides.
Therapeutic advances in chronic disease
Pfeil J,Simonetti M,Lauer U,von Thülen B,Durek P,Poulsen C,Pawlowska J,Kröger M,Krähmer R,Leenders F,Hoffmann U,Hamann A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Nov 07 00:00:00 EST 2023
Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.
Human gene therapy
Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Identification of CTL Epitopes on Efflux Pumps of the ATP-Binding Cassette and the Major Facilitator Superfamily of Mycobacterium tuberculosis.
Journal of immunology research
Lin Y,Dong Y,Gao Y,Shi R,Li Y,Zhou X,Liu W,Li G,Qi Y,Wu Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Fine particulate matter induces airway inflammation by disturbing the balance between Th1/Th2 and regulation of GATA3 and Runx3 expression in BALB/c mice.
Molecular medicine reports
Pang L,Yu P,Liu X,Fan Y,Shi Y,Zou S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Features of T-cell subset composition in a D-galactose-induced senescence mouse model.
Experimental animals
Kawata K,Suzuki T,Ozawa K,Sekiguchi M
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Aug 06 00:00:00 EDT 2021
Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Faslpr Mice.
Cells
Schmidtke L,Meineck M,Saurin S,Otten S,Gather F,Schrick K,Käfer R,Roth W,Kleinert H,Weinmann-Menke J,Pautz A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Immunohistochemistry
Sun Nov 14 00:00:00 EST 2021
Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Faslpr Mice.
Cells
Schmidtke L,Meineck M,Saurin S,Otten S,Gather F,Schrick K,Käfer R,Roth W,Kleinert H,Weinmann-Menke J,Pautz A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Immunohistochemistry
Sun Nov 14 00:00:00 EST 2021
T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
JCI insight
Chun N,Ang RL,Chan M,Fairchild RL,Baldwin WM,Horwitz JK,Gelles JD,Chipuk JE,Kelliher MA,Pavlov VI,Li Y,Homann D,Heeger PS,Ting AT
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Dec 22 00:00:00 EST 2021
Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition.
Oncoimmunology
Lione L,Salvatori E,Petrazzuolo A,Massacci A,Maggio R,Confroti A,Compagnone M,Aurisicchio L,Ciliberto G,Palombo F
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Mar 23 00:00:00 EDT 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation.
Frontiers in immunology
Liu J,Liu Y,Panda S,Liu A,Lei J,Burd I
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Dec 17 00:00:00 EST 2021
Macrophages Compensate for Loss of Protein Tyrosine Phosphatase N2 in Dendritic Cells to Protect from Elevated Colitis.
International journal of molecular sciences
Hering L,Katkeviciute E,Schwarzfischer M,Niechcial A,Riggs JB,Wawrzyniak M,Atrott K,van de Sande M,Lang S,Becher B,Rogler G,Scharl M,Spalinger MR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Immunohistochemistry
Fri Jun 25 00:00:00 EDT 2021
Exosome-mediated mRNA delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity.
The Journal of biological chemistry
Tsai SJ,Atai NA,Cacciottolo M,Nice J,Salehi A,Guo C,Sedgwick A,Kanagavelu S,Gould SJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2021
Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer.
Nature communications
Huang Y,Guan Z,Dai X,Shen Y,Wei Q,Ren L,Jiang J,Xiao Z,Jiang Y,Liu D,Huang Z,Xu X,Luo Y,Zhao C
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Jul 14 00:00:00 EDT 2021
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis.
Scientific reports
AuYeung AWK,Mould RC,Stegelmeier AA,van Vloten JP,Karimi K,Woods JP,Petrik JJ,Wood GA,Bridle BW
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis.
JCI insight
Lin J,Tang J,Lin J,He Y,Yu Z,Jiang R,Yang B,Ou Q
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Nov 22 00:00:00 EST 2021
Small Molecule Inhibitors Targeting Nuclear Factor κB Activation Markedly Reduce Expression of Interleukin-2, but Not Interferon-γ, Induced by Phorbol Esters and Calcium Ionophores.
International journal of molecular sciences
Tanaka Y,Nakao A,Miyake Y,Higashi Y,Tanigaki R,Kataoka T
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Dec 03 00:00:00 EST 2021
SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis.
iScience
Sangaletti S,Botti L,Gulino A,Lecis D,Bassani B,Portararo P,Milani M,Cancila V,De Cecco L,Dugo M,Tripodo C,Colombo MP
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
14-7311-81 was used in Flow Cytometry to show that phenylethanol N-methyltransferase (PNMT), a rate-limiting enzyme of epinephrine synthesis, is specifically expressed in vitro in differentiated TH17 cells and in tissue-resident TH17 cells.
Mon Jul 05 00:00:00 EDT 2021
Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection.
iScience
Steele L,Mannion AJ,Shaw G,Maclennan KA,Cook GP,Rudd CE,Taylor A
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jun 25 00:00:00 EDT 2021
Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry.
STAR protocols
Skordos I,Demeyer A,Beyaert R
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 19 00:00:00 EDT 2021
Long-Term Programming of CD8 T Cell Immunity by Perinatal Exposure to Glucocorticoids.
Cell
Hong JY,Lim J,Carvalho F,Cho JY,Vaidyanathan B,Yu S,Annicelli C,Ip WKE,Medzhitov R
14-7311 was used in an ELISA assay to demonstrate that perinatal stress can have long-term consequences on CD8 T cell immunity by altering HPA axis activity.
Thu Mar 05 00:00:00 EST 2020
Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.
Immunity
Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2020
Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.
PLoS pathogens
Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Deletion of Ppard in CD11c+ cells attenuates atherosclerosis in ApoE knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Tian D,Hong H,Shang W,Ho CC,Dong J,Tian XY
14-7311-81 was used in Flow Cytometry to study the involvement of PPARδ in CD11c+ cells in atherosclerosis.
Sat Feb 01 00:00:00 EST 2020
Expression of CD27 and CD28 on γδ T cells from the peripheral blood of patients with allergic rhinitis.
Experimental and therapeutic medicine
Wang Q,Sun Q,Chen Q,Li H,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2020
Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection.
Experimental and therapeutic medicine
Chang L,Wang L,Ling N,Peng H,Chen M
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine.
Journal of immunological methods
Webster HC,Andrusaite AT,Shergold AL,Milling SWF,Perona-Wright G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 27 00:00:00 EDT 2020
C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection.
Frontiers in immunology
Briukhovetska D,Ohm B,Mey FT,Aliberti J,Kleingarn M,Huber-Lang M,Karsten CM,Köhl J
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Apr 14 00:00:00 EDT 2020
FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.
Cell death & disease
Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Apr 24 00:00:00 EDT 2020
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Nov 05 00:00:00 EST 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Jun 11 00:00:00 EDT 2020
BCG vaccination reduces the mortality of Mycobacterium tuberculosis-infected type 2 diabetes mellitus mice.
JCI insight
Radhakrishnan RK,Thandi RS,Tripathi D,Paidipally P,McAllister MK,Mulik S,Samten B,Vankayalapati R
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Mar 12 00:00:00 EDT 2020
Tumors induce de novo steroid biosynthesis in T cells to evade immunity.
Nature communications
Mahata B,Pramanik J,van der Weyden L,Polanski K,Kar G,Riedel A,Chen X,Fonseca NA,Kundu K,Campos LS,Ryder E,Duddy G,Walczak I,Okkenhaug K,Adams DJ,Shields JD,Teichmann SA
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jul 17 00:00:00 EDT 2020
Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.
Cell communication and signaling : CCS
Klepsch V,Pommermayr M,Humer D,Brigo N,Hermann-Kleiter N,Baier G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jan 14 00:00:00 EST 2020
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response.
Nature communications
Chen J,He R,Sun W,Gao R,Peng Q,Zhu L,Du Y,Ma X,Guo X,Zhang H,Tan C,Wang J,Zhang W,Weng X,Man J,Bauer H,Wang QK,Martin BN,Zhang CJ,Li X,Wang C
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Apr 20 00:00:00 EDT 2020
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.
Nature communications
Iske J,Seyda M,Heinbokel T,Maenosono R,Minami K,Nian Y,Quante M,Falk CS,Azuma H,Martin F,Passos JF,Niemann CU,Tchkonia T,Kirkland JL,Elkhal A,Tullius SG
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Aug 27 00:00:00 EDT 2020
PCC0208025 (BMS202), a small molecule inhibitor of PD-L1, produces an antitumor effect in B16-F10 melanoma-bearing mice.
PloS one
Hu Z,Yu P,Du G,Wang W,Zhu H,Li N,Zhao H,Dong Z,Ye L,Tian J
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jun 22 00:00:00 EDT 2020
TNIK signaling imprints CD8+ T cell memory formation early after priming.
Nature communications
Jaeger-Ruckstuhl CA,Hinterbrandner M,Höpner S,Correnti CE,Lüthi U,Friedli O,Freigang S,Al Sayed MF,Bührer ED,Amrein MA,Schürch CM,Radpour R,Riether C,Ochsenbein AF
14-7311-81 was used in Flow Cytometry to analyse the role of the TRAF2-/NCK-interacting kinase (TNIK), a signaling molecule downstream of the tumor necrosis factor superfamily receptors such as CD27, in the regulation of CD8+ T cell fate during acute infection with lymphocytic choriomeningitis virus.
Thu Apr 02 00:00:00 EDT 2020
Bmal1 integrates mitochondrial metabolism and macrophage activation.
eLife
Alexander RK,Liou YH,Knudsen NH,Starost KA,Xu C,Hyde AL,Liu S,Jacobi D,Liao NS,Lee CH
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue May 12 00:00:00 EDT 2020
Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma.
Journal for immunotherapy of cancer
Shigeta K,Matsui A,Kikuchi H,Klein S,Mamessier E,Chen IX,Aoki S,Kitahara S,Inoue K,Shigeta A,Hato T,Ramjiawan RR,Staiculescu D,Zopf D,Fiebig L,Hobbs GS,Quaas A,Dima S,Popescu I,Huang P,Munn LL,Cobbold M,Goyal L,Zhu AX,Jain RK,Duda DG
14-7311-81 was used in Flow Cytometry to conclude that judicious regorafenib/anti-PD1 combination therapy can inhibit tumor growth and increase survival by normalizing tumor vasculature and increasing intratumoral CXCR3+CD8 T-cell infiltration through elevated CXCL10 expression in HCC cells.
Sun Nov 01 00:00:00 EDT 2020
PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction.
Cell reports
Yin X,Zeng W,Wu B,Wang L,Wang Z,Tian H,Wang L,Jiang Y,Clay R,Wei X,Qin Y,Zhang F,Zhang C,Jin L,Liang W
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Oct 20 00:00:00 EDT 2020
Tolerogenic Immunomodulation by PEGylated Antigenic Peptides.
Frontiers in immunology
Pfeil J,Simonetti M,Lauer U,Volkmer R,von Thülen B,Durek P,Krähmer R,Leenders F,Hamann A,Hoffmann U
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Apr 29 00:00:00 EDT 2021
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.
Frontiers in immunology
Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jun 21 00:00:00 EDT 2021
TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
Science immunology
Harbour SN,DiToro DF,Witte SJ,Zindl CL,Gao M,Schoeb TR,Jones GW,Jones SA,Hatton RD,Weaver CT
14-7311-81 was used in Cell Culture to find that IL-6 signaling is required for both induction and maintenance of mouse TH17 cells; IL-6Rα-deficient TH17 cells rapidly lost their TH17 phenotype and did not cause disease in two models of colitis.
Fri Jul 17 00:00:00 EDT 2020
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-7311-81 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity.
Cell research
Wang Y,Du X,Wei J,Long L,Tan H,Guy C,Dhungana Y,Qian C,Neale G,Fu YX,Yu J,Peng J,Chi H
14-7311-81 was used in Flow cytometry/Cell sorting to understand how dendritic cells control excessive and deleterious T cell responses.
Wed May 01 00:00:00 EDT 2019
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-7311-81 was used in Immunohistochemistry to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes and promotes T cell-mediated tumor regression.
The Journal of experimental medicine
Etzerodt A,Tsalkitzi K,Maniecki M,Damsky W,Delfini M,Baudoin E,Moulin M,Bosenberg M,Graversen JH,Auphan-Anezin N,Moestrup SK,Lawrence T
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Oct 07 00:00:00 EDT 2019
The complex of MCMV proteins and MHC class I evades NK cell control and drives the evolution of virus-specific activating Ly49 receptors.
The Journal of experimental medicine
Železnjak J,Lisnić VJ,Popović B,Lisnić B,Babić M,Halenius A,L'Hernault A,Roviš TL,Hengel H,Erhard F,Redwood AJ,Vidal SM,Dölken L,Krmpotić A,Jonjić S
14-7311 was used in Flow cytometry/Cell sorting to solve a long-standing conundrum of how MCMV avoids recognition by NK cells, unravels a fundamental new viral immune evasion mechanism, and demonstrates how this forced the evolution of virus-specific activating MHC I-restricted Ly49 receptors.
Mon Aug 05 00:00:00 EDT 2019
miR-146a Controls Immune Response in the Melanoma Microenvironment.
Cancer research
Mastroianni J,Stickel N,Andrlova H,Hanke K,Melchinger W,Duquesne S,Schmidt D,Falk M,Andrieux G,Pfeifer D,Dierbach H,Schmitt-Graeff A,Meiss F,Boerries M,Zeiser R
14-7311-81 was used in Flow Cytometry to identify miR-146a as a negative regulator of immune activation, comparable to immune-checkpoint molecules.
Tue Jan 01 00:00:00 EST 2019
BTK signaling drives CD1dhiCD5+ regulatory B-cell differentiation to promote pancreatic carcinogenesis.
Oncogene
Das S,Bar-Sagi D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Apr 01 00:00:00 EDT 2019
The ROP16III-dependent early immune response determines the subacute CNS immune response and type III Toxoplasma gondii survival.
PLoS pathogens
Tuladhar S,Kochanowsky JA,Bhaskara A,Ghotmi Y,Chandrasekaran S,Koshy AA
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function.
Inflammatory bowel diseases
De Vries LCS,Duarte JM,De Krijger M,Welting O,Van Hamersveld PHP,Van Leeuwen-Hilbers FWM,Moerland PD,Jongejan A,D'Haens GR,De Jonge WJ,Wildenberg ME
14-7311 was used in Flow cytometry/Cell sorting to study the potential of tofacitinib to affect macrophage activation.
Thu Mar 14 00:00:00 EDT 2019
CD8+ T cells promote cytokine responses to stress.
Cytokine
Clark SM,Song C,Li X,Keegan AD,Tonelli LH
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.
Biology open
Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jan 15 00:00:00 EST 2019
An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.
NPJ vaccines
Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.
Nature communications
Scheer S,Ackloo S,Medina TS,Schapira M,Li F,Ward JA,Lewis AM,Northrop JP,Richardson PL,Kaniskan HÜ,Shen Y,Liu J,Smil D,McLeod D,Zepeda-Velazquez CA,Luo M,Jin J,Barsyte-Lovejoy D,Huber KVM,De Carvalho DD,Vedadi M,Zaph C,Brown PJ,Arrowsmith CH
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Jan 03 00:00:00 EST 2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
Nature communications
Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Mar 20 00:00:00 EDT 2019
Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy.
Nature communications
Shi L,Wang J,Ding N,Zhang Y,Zhu Y,Dong S,Wang X,Peng C,Zhou C,Zhou L,Li X,Shi H,Wu W,Long X,Wu C,Liao W
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Requirement of Mitochondrial Transcription Factor A in Tissue-Resident Regulatory T Cell Maintenance and Function.
Cell reports
Fu Z,Ye J,Dean JW,Bostick JW,Weinberg SE,Xiong L,Oliff KN,Chen ZE,Avram D,Chandel NS,Zhou L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jul 02 00:00:00 EDT 2019
Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis.
Cell reports
Wang B,Lim JH,Kajikawa T,Li X,Vallance BA,Moutsopoulos NM,Chavakis T,Hajishengallis G
14-7311 was used in Flow cytometry/Cell sorting to conclude that β2-integrins are required for protective IL-1β-dependent IL-22 responses in colitis, and the identified mechanism may underlie the association of human LAD1 with colitis.
Tue Feb 05 00:00:00 EST 2019
Tbet Expression in Regulatory T Cells Is Required to Initiate Th1-Mediated Colitis.
Frontiers in immunology
Di Giovangiulio M,Rizzo A,Franzè E,Caprioli F,Facciotti F,Onali S,Favale A,Stolfi C,Fehling HJ,Monteleone G,Fantini MC
14-7311-81 was used in Flow Cytometry to investigate the functional role of T helper type 1-like Tregs in the dextran sulfate model of colitis.
Wed Oct 21 00:00:00 EDT 2020
Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation.
JCI insight
Kono M,Maeda K,Stocton-Gavanescu I,Pan W,Umeda M,Katsuyama E,Burbano C,Orite SYK,Vukelic M,Tsokos MG,Yoshida N,Tsokos GC
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that CaMK4 binds to PKM2 and promotes its activity, which is requisite for Th1 and Th17 differentiation.
Thu Jun 20 00:00:00 EDT 2019
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-7311 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Pathogenic function of bystander-activated memory-like CD4+ T cells in autoimmune encephalomyelitis.
Nature communications
Lee HG,Lee JU,Kim DH,Lim S,Kang I,Choi JM
14-7311-81 was used in Flow Cytometry to reveal the innate-like pathogenic function of antigen non-related memory CD4+ T cells, which contribute to the development of autoimmune diseases.
Tue Feb 12 00:00:00 EST 2019
An obligatory role for club cells in preventing obliterative bronchiolitis in lung transplants.
JCI insight
Liu Z,Liao F,Scozzi D,Furuya Y,Pugh KN,Hachem R,Chen DL,Cano M,Green JM,Krupnick AS,Kreisel D,Perl AKT,Huang HJ,Brody SL,Gelman AE
14-7311-81 was used in Flow cytometry/Cell sorting to demonstrate a vital role for club cells in maintaining lung transplant tolerance and propose a new model to identify the underlying mechanisms of OB.
Tue Apr 16 00:00:00 EDT 2019
Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock.
Frontiers in immunology
Manson J,Hoffman R,Chen S,Ramadan MH,Billiar TR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 13 00:00:00 EDT 2020
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-7311 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Frontiers in immunology
Zhang H,Hu Q,Zhang M,Yang F,Peng C,Zhang Z,Huang C
14-7311 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms through which the transcription factor Bach2 controls autoimmunity.
Mon Oct 19 00:00:00 EDT 2020
Targeting Mutated Plus Germline Epitopes Confers Pre-clinical Efficacy of an Instantly Formulated Cancer Nano-Vaccine.
Frontiers in immunology
Mohsen MO,Vogel M,Riether C,Muller J,Salatino S,Ternette N,Gomes AC,Cabral-Miranda G,El-Turabi A,Ruedl C,Kundig TM,Dermime S,Knuth A,Speiser DE,Bachmann MF
14-7311-81 was used in Flow Cytometry to develop a personalized cancer nano-vaccine platform based on virus-like particles loaded with toll-like receptor ligands.
Wed Sep 09 00:00:00 EDT 2020
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer.
Immunity
Malik A,Sharma D,Malireddi RKS,Guy CS,Chang TC,Olsen SR,Neale G,Vogel P,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Sep 18 00:00:00 EDT 2018
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Immunity
Kim M,Galan C,Hill AA,Wu WJ,Fehlner-Peach H,Song HW,Schady D,Bettini ML,Simpson KW,Longman RS,Littman DR,Diehl GE
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Jul 17 00:00:00 EDT 2018
Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.
Immunity
Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.
The Journal of clinical investigation
Mande P,Zirak B,Ko WC,Taravati K,Bride KL,Brodeur TY,Deng A,Dresser K,Jiang Z,Ettinger R,Fitzgerald KA,Rosenblum MD,Harris JE,Marshak-Rothstein A
14-7311 was used in Flow cytometry/Cell sorting to provide a relevant system for exploring the pathophysiology of cutaneous lupus erythematosus (CLE) as well as the negative regulatory role of TLR9.
Mon Jul 02 00:00:00 EDT 2018
The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation.
The Journal of experimental medicine
Zhang W,Li Q,Li D,Li J,Aki D,Liu YC
14-7311 was used in Flow cytometry/Cell sorting to show VHL regulates alveolar macrophages and acts as a crucial egulatory factor in lung inflammation and fibrosis.
Mon Dec 03 00:00:00 EST 2018
Glucagon-like peptide 1 receptor signaling attenuates respiratory syncytial virus-induced type 2 responses and immunopathology.
The Journal of allergy and clinical immunology
Bloodworth MH,Rusznak M,Pfister CC,Zhang J,Bastarache L,Calvillo SA,Chappell JD,Boyd KL,Toki S,Newcomb DC,Stier MT,Zhou W,Goleniewska K,Moore ML,Hartert TV,Niswender KD,Peebles RS
14-7311 was used in Flow cytometry/Cell sorting to investigate the effect of activating the GLP-1R signalling pathway on mice mimicking severe respiratory infection.
Wed Aug 01 00:00:00 EDT 2018
Co-infection with Chikungunya virus alters trafficking of pathogenic CD8+ T cells into the brain and prevents Plasmodium-induced neuropathology.
EMBO molecular medicine
Teo TH,Howland SW,Claser C,Gun SY,Poh CM,Lee WW,Lum FM,Ng LF,Rénia L
14-7311-81 was used in Flow Cytometry to study the effects of Chikungunya virus co-infection on the severity and susceptibility of malaria infection.
Mon Jan 01 00:00:00 EST 2018
Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress.
PLoS biology
Mensurado S,Rei M,Lança T,Ioannou M,Gonçalves-Sousa N,Kubo H,Malissen M,Papayannopoulos V,Serre K,Silva-Santos B
14-7311 was used in Flow cytometry/Cell sorting to study the role of tumour-associated neutrophils in the regulation of γδ17 T-cell responses in the tumour microenvironment.
Tue May 01 00:00:00 EDT 2018
Cambogin suppresses dextran sulphate sodium-induced colitis by enhancing Treg cell stability and function.
British journal of pharmacology
Lu Y,Kim NM,Jiang YW,Zhang H,Zheng D,Zhu FX,Liang R,Li B,Xu HX
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments.
EMBO reports
Lee S,Park K,Kim J,Min H,Seong RH
14-7311-81 was used in T-Cell Activation to show CCAAT/enhancer-binding protein can enhance TGF-β-induced Foxp3+ regulatory T cell generation.
Sat Dec 01 00:00:00 EST 2018
Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity.
The Journal of investigative dermatology
Rafei-Shamsabadi DA,van de Poel S,Dorn B,Kunz S,Martin SF,Klose CSN,Arnold SJ,Tanriver Y,Ebert K,Diefenbach A,Halim TYF,McKenzie ANJ,Jakob T
14-7311 was used in Flow cytometry/Cell sorting to suggest that ILC2 act as negative regulators in the type 1-dominated immune response of contact hypersensitivity.
Sat Sep 01 00:00:00 EDT 2018
The adaptor molecule CD2AP in CD4 T cells modulates differentiation of follicular helper T cells during chronic LCMV infection.
PLoS pathogens
Raju S,Kometani K,Kurosaki T,Shaw AS,Egawa T
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that inactivation of the signaling adaptor CD2-associated protein (CD2AP) promotes CD4 T cell differentiation towards the follicular helper lineage.
Tue May 01 00:00:00 EDT 2018
MicroRNA-126 deficiency enhanced the activation and function of CD4+ T cells by elevating IRS-1 pathway.
Clinical and experimental immunology
Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Smith CJ,Allard DE,Wang Y,Howard JF,Montgomery SA,Su MA
14-7311 was used in Flow cytometry/Cell sorting to delineate a novel mechanism in which IL-10-induced STAT3 increases S1pr1 expression and CD4+ T cell migration to accelerate T cell-mediated destruction of peripheral nerves.
Thu Mar 01 00:00:00 EST 2018
The Atypical Chemokine Receptor Ackr2 Constrains NK Cell Migratory Activity and Promotes Metastasis.
Journal of immunology (Baltimore, Md. : 1950)
Hansell CAH,Fraser AR,Hayes AJ,Pingen M,Burt CL,Lee KM,Medina-Ruiz L,Brownlie D,Macleod MKL,Burgoyne P,Wilson GJ,Nibbs RJB,Graham GJ
14-7311-81 was used in Flow Cytometry to determine the role of Ackr2 in metastasis.
Mon Oct 15 00:00:00 EDT 2018
Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.
Evidence-based complementary and alternative medicine : eCAM
Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis.
Open life sciences
Wang H,Xiao Y,Su L,Cui N,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae.
Nature communications
Chandra S,Gray J,Kiosses WB,Khurana A,Hitomi K,Crosby CM,Chawla A,Fu Z,Zhao M,Veerapen N,Richardson SK,Porcelli SA,Besra G,Howell AR,Sharma S,Peters B,Kronenberg M
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Oct 15 00:00:00 EDT 2018
Modifying the cancer-immune set point using vaccinia virus expressing re-designed interleukin-2.
Nature communications
Liu Z,Ge Y,Wang H,Ma C,Feist M,Ju S,Guo ZS,Bartlett DL
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Nov 08 00:00:00 EST 2018
Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion.
Nature communications
Sun C,Lan P,Han Q,Huang M,Zhang Z,Xu G,Song J,Wang J,Wei H,Zhang J,Sun R,Zhang C,Tian Z
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Mar 28 00:00:00 EDT 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Mar 22 00:00:00 EDT 2018
Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis.
Nature communications
Kim DH,Park HJ,Lim S,Koo JH,Lee HG,Choi JO,Oh JH,Ha SJ,Kang MJ,Lee CM,Lee CG,Elias JA,Choi JM
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Feb 05 00:00:00 EST 2018
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Nature communications
Zhu L,Xie X,Zhang L,Wang H,Jie Z,Zhou X,Shi J,Zhao S,Zhang B,Cheng X,Sun SC
14-7311 was used in an ELISA assay to study the mechanism of IL-15 function in autophagy and natural killer cell survival.
Wed Jul 18 00:00:00 EDT 2018
Inflammation-induced Id2 promotes plasticity in regulatory T cells.
Nature communications
Hwang SM,Sharma G,Verma R,Byun S,Rudra D,Im SH
14-7311 was used in Flow cytometry/Cell sorting to show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of Treg into ex-Foxp3 TH17 cells.
Fri Nov 09 00:00:00 EST 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-7311 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 EDT 2018
Regulation of the effector function of CD8+ T cells by gut microbiota-derived metabolite butyrate.
Scientific reports
Luu M,Weigand K,Wedi F,Breidenbend C,Leister H,Pautz S,Adhikary T,Visekruna A
14-7311 was used in Flow cytometry/Cell sorting to might have significant implications in adoptive immunotherapy of cancers and in anti-viral immunity.
Wed Sep 26 00:00:00 EDT 2018
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-7311-81 was used in Flow Cytometry to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-7311 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Wed Feb 01 00:00:00 EST 2017
Excessive expression of miR-27 impairs Treg-mediated immunological tolerance.
The Journal of clinical investigation
Cruz LO,Hashemifar SS,Wu CJ,Cho S,Nguyen DT,Lin LL,Khan AA,Lu LF
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Wed Feb 01 00:00:00 EST 2017
Combined antiangiogenic and anti-PD-L1 therapy stimulates tumor immunity through HEV formation.
Science translational medicine
Allen E,Jabouille A,Rivera LB,Lodewijckx I,Missiaen R,Steri V,Feyen K,Tawney J,Hanahan D,Michael IP,Bergers G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Xu X,Han L,Zhao G,Xue S,Gao Y,Xiao J,Zhang S,Chen P,Wu ZY,Ding J,Hu R,Wei B,Wang H
14-7311 was used in Flow cytometry/Cell sorting to demonstrate LRCH1 as a novel effector to restrain PKCα-DOCK8-Cdc42 module-induced T cell migration and ameliorate EAE.
Sun Jan 01 00:00:00 EST 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.
Cancer immunology research
Kubo H,Mensurado S,Gonçalves-Sousa N,Serre K,Silva-Santos B
14-7311-81 was used in Flow Cytometry to identifies an innate cell network and the molecular determinants responsible for metastasis immunosurveillance, providing support for using the key molecular mediator to improve immunotherapeutic outcomes.
Fri Sep 01 00:00:00 EDT 2017
Microbial, metabolomic, and immunologic dynamics in a relapsing genetic mouse model of colitis induced by T-synthase deficiency.
Gut microbes
Jacobs JP,Lin L,Goudarzi M,Ruegger P,McGovern DP,Fornace AJ,Borneman J,Xia L,Braun J
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jan 02 00:00:00 EST 2017
A New Adjuvant MTOM Mediates Mycobacterium tuberculosis Subunit Vaccine to Enhance Th1-Type T Cell Immune Responses and IL-2+ T Cells.
Frontiers in immunology
Yu Q,Wang X,Fan X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Critical role of caspase-8-mediated IL-1 signaling in promoting Th2 responses during asthma pathogenesis.
Mucosal immunology
Qi X,Gurung P,Malireddi RK,Karmaus PW,Sharma D,Vogel P,Chi H,Green DR,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sun Jan 01 00:00:00 EST 2017
Transcriptional determinants of tolerogenic and immunogenic states during dendritic cell maturation.
The Journal of cell biology
Vander Lugt B,Riddell J,Khan AA,Hackney JA,Lesch J,DeVoss J,Weirauch MT,Singh H,Mellman I
14-7311 was used in Flow cytometry/Cell sorting to study how DCs modulate their ability to prime tolerogenic or immunogenic T cells by expressing a core antigen presentation module that is overlaid by distinctive regulatory modules to promote either tolerance or immunity.
Mon Mar 06 00:00:00 EST 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-7311-81 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology.
PLoS pathogens
Pyle CJ,Uwadiae FI,Swieboda DP,Harker JA
14-7311-81 was used in Flow Cytometry to show that during respiratory virus infection the prototypic inflammatory cytokine IL-6 is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27.
Fri Sep 01 00:00:00 EDT 2017
Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.
Acta pharmacologica Sinica
Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Feb 01 00:00:00 EST 2017
Role of Triggering Receptor Expressed on Myeloid Cell-1 Expression in Mammalian Target of Rapamycin Modulation of CD8+ T-cell Differentiation during the Immune Response to Invasive Pulmonary Aspergillosis.
Chinese medical journal
Cui N,Wang H,Su LX,Zhang JH,Long Y,Liu DW
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat May 20 00:00:00 EDT 2017
Lamtor1 Is Critically Required for CD4+ T Cell Proliferation and Regulatory T Cell Suppressive Function.
Journal of immunology (Baltimore, Md. : 1950)
Hosokawa T,Kimura T,Nada S,Okuno T,Ito D,Kang S,Nojima S,Yamashita K,Nakatani T,Hayama Y,Kato Y,Kinehara Y,Nishide M,Mikami N,Koyama S,Takamatsu H,Okuzaki D,Ohkura N,Sakaguchi S,Okada M,Kumanogoh A
14-7311 was used in an ELISA assay to demonstrate that Lamtor1-deficient CD4(+) T cells exhibit marked reductions in proliferation, IL-2 production, Mechanistic target of rapamycin complex 1 activity, and expression of purine- and lipid-synthesis genes.
Fri Sep 15 00:00:00 EDT 2017
miR-451 limits CD4+ T cell proliferative responses to infection in mice.
Immunologic research
Chapman LM,Ture SK,Field DJ,Morrell CN
14-7311-81 was used in Flow Cytometry to demonstrate that miR-451 is a regulator of host immune responses to Plasmodium infection, particularly in the control of CD4+ T cell proliferation via a Myc-dependent pathway.
Tue Aug 01 00:00:00 EDT 2017
Macrophage regulation of B cell proliferation.
Cellular immunology
Goldman N,Valiuskyte K,Londregan J,Swider A,Somerville J,Riggs JE
14-7311 was used in Neutralization assays to assess the ability of peritoneal cavity B cells to respond to surrogate activating signals in the presence of high numbers of macrophages.
Sat Apr 01 00:00:00 EDT 2017
Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells.
Virology
Qin Q,Lauver M,Maru S,Lin E,Lukacher AE
14-7311-81 was used in Flow Cytometry to show differentiation of protective virus-specific memory CD8 T cells in patients can be promoted by reducing viral load during persistent polyomavirus infection.
Wed Feb 01 00:00:00 EST 2017
Glycolysis and glutaminolysis cooperatively control T cell function by limiting metabolite supply to N-glycosylation.
eLife
Araujo L,Khim P,Mkhikian H,Mortales CL,Demetriou M
14-7311 was used in an ELISA assay to report that aerobic glycolysis and glutaminolysis co-operatively reduce UDP-GlcNAc biosynthesis and N-glycan branching in mouse T cell blasts by starving the hexosamine pathway of glucose and glutamine.
Fri Jan 06 00:00:00 EST 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
ORAI2 modulates store-operated calcium entry and T cell-mediated immunity.
Nature communications
Vaeth M,Yang J,Yamashita M,Zee I,Eckstein M,Knosp C,Kaufmann U,Karoly Jani P,Lacruz RS,Flockerzi V,Kacskovics I,Prakriya M,Feske S
14-7311-81 was used in Flow Cytometry to demonstrate that ORAI1 and ORAI2 form heteromeric CRAC channels in which ORAI2 fine-tunes the magnitude of SOCE to modulate immune responses.
Wed Mar 15 00:00:00 EDT 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Feb 06 00:00:00 EST 2017
Signal-transducing adaptor protein-2 promotes generation of functional long-term memory CD8+ T cells by preventing terminal effector differentiation.
Oncotarget
Muraoka D,Seo N,Hayashi T,Hyuga-Amaike C,Okamori K,Tawara I,Harada N,Shiku H
14-7311 was used in Flow cytometry/Cell sorting to determine the regulatory mechanism of signal transducer and activator of transcription proteins in CD8+T cells.
Tue May 09 00:00:00 EDT 2017
IL-12 Influence mTOR to Modulate CD8+ T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis.
International journal of medical sciences
Wang H,Li J,Han Q,Yang F,Xiao Y,Xiao M,Xu Y,Su L,Cui N,Liu D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Blocking CTLA-4 while priming with a whole cell vaccine reshapes the oligoclonal T cell infiltrate and eradicates tumors in an orthotopic glioma model.
Oncoimmunology
Field CS,Hunn MK,Ferguson PM,Ruedl C,Ancelet LR,Hermans IF
14-7311-81 was used in Flow Cytometry to study the effect of the checkpoint blockade on the efficacy of responses induced with a whole tumour-cell vaccine.
Tue Jan 12 00:00:00 EST 2021
A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages.
eLife
Morales AJ,Carrero JA,Hung PJ,Tubbs AT,Andrews JM,Edelson BT,Calderon B,Innes CL,Paules RS,Payton JE,Sleckman BP
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of genotoxic agents produced by macrophages in inflammasome activation.
Fri Mar 31 00:00:00 EDT 2017
The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma.
Oncotarget
Cho JH,Lee HJ,Ko HJ,Yoon BI,Choe J,Kim KC,Hahn TW,Han JA,Choi SS,Jung YM,Lee KH,Lee YS,Jung YJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Apr 11 00:00:00 EDT 2017
Ex vivo modulation of the Foxo1 phosphorylation state does not lead to dysfunction of T regulatory cells.
PloS one
Penberthy KK,Buckley MW,Arandjelovic S,Ravichandran K
14-7311 was used in Functional assays to study the effect of FoxO1 phosphorylation state on T regulatory cell function.
Fri Aug 25 00:00:00 EDT 2017
Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice.
JCI insight
Robert R,Ang C,Sun G,Juglair L,Lim EX,Mason LJ,Payne NL,Bernard CC,Mackay CR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 17 00:00:00 EDT 2017
A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.
EBioMedicine
Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2017
Blocking C5aR signaling promotes the anti-tumor efficacy of PD-1/PD-L1 blockade.
Oncoimmunology
Zha H,Han X,Zhu Y,Yang F,Li Y,Li Q,Guo B,Zhu B
14-7311-81 was used in Flow Cytometry to demonstrate the immunosuppressive effects of complement activation following the administration of PD-1/PD-L1 antibody therapy, and reveal that blocking C5aR signaling increased anti-tumor efficacy.
Tue Jan 12 00:00:00 EST 2021
An asthma-associated IL4R variant exacerbates airway inflammation by promoting conversion of regulatory T cells to TH17-like cells.
Nature medicine
Massoud AH,Charbonnier LM,Lopez D,Pellegrini M,Phipatanakul W,Chatila TA
14-7311 was used in Flow cytometry/Cell sorting to identify a previously unknown mechanism for the development of TH17 cell inflammation in genetically prone individuals.
Thu Sep 01 00:00:00 EDT 2016
NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.
Nature
Karki R,Man SM,Malireddi RKS,Kesavardhana S,Zhu Q,Burton AR,Sharma BR,Qi X,Pelletier S,Vogel P,Rosenstiel P,Kanneganti TD
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Dec 22 00:00:00 EST 2016
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche.
Cell
Clever D,Roychoudhuri R,Constantinides MG,Askenase MH,Sukumar M,Klebanoff CA,Eil RL,Hickman HD,Yu Z,Pan JH,Palmer DC,Phan AT,Goulding J,Gattinoni L,Goldrath AW,Belkaid Y,Restifo NP
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Maternal-Derived Hepatitis B Virus e Antigen Alters Macrophage Function in Offspring to Drive Viral Persistence after Vertical Transmission.
Immunity
Tian Y,Kuo CF,Akbari O,Ou JH
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue May 17 00:00:00 EDT 2016
Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
Nature immunology
Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2016
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.
The Journal of clinical investigation
Patterson SJ,Pesenacker AM,Wang AY,Gillies J,Mojibian M,Morishita K,Tan R,Kieffer TJ,Verchere CB,Panagiotopoulos C,Levings MK
14-7311 was used in Flow cytometry/Cell sorting to investigate how Treg-to-target proximity is controlled.
Tue Mar 01 00:00:00 EST 2016
CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.
Mucosal immunology
Arnold IC,Mathisen S,Schulthess J,Danne C,Hegazy AN,Powrie F
14-7311 was used in Flow cytometry/Cell sorting to investigate the mechanism by which IL-23 produced by CD11c+ monocytes/macrophages promotes chronic Helicobacter hepaticus-induced intestinal inflammation.
Tue Mar 01 00:00:00 EST 2016
Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Chow KV,Lew AM,Sutherland RM,Zhan Y
14-7311 was used in Flow cytometry/Cell sorting to investigate how division of labor between moDCs and cDCs has implications for their respective roles in the immune response.
Fri Jan 15 00:00:00 EST 2016
Differential Responsiveness of Innate-like IL-17- and IFN-γ-Producing γδ T Cells to Homeostatic Cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Corpuz TM,Stolp J,Kim HO,Pinget GV,Gray DH,Cho JH,Sprent J,Webster KE
14-7311-81 was used in Flow Cytometry to suggest that γδ T cell subsets do not directly compete with each other for cytokines, but instead fall into resource niches with other functionally similar lymphocytes.
Fri Jan 15 00:00:00 EST 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-7311 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chow KV,Delconte RB,Huntington ND,Tarlinton DM,Sutherland RM,Zhan Y,Lew AM
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that monocyte-derived dendritic cells arise in response to allogeneic Ag encounters.
Thu Sep 01 00:00:00 EDT 2016
Group B Streptococcus Induces a Robust IFN-γ Response by CD4(+) T Cells in an In Vitro and In Vivo Model.
Journal of immunology research
Clarke D,Letendre C,Lecours MP,Lemire P,Galbas T,Thibodeau J,Segura M
14-7311 was used in Flow cytometry/Cell sorting to investigate the source of IFN-γ during group B Streptococcus serotype III infection, showing robust IFN-γ response by CD4(+) T cells.
Tue Nov 01 00:00:00 EDT 2016
Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.
Autoimmunity
Haddad CS,Bhattacharya P,Alharshawi K,Marinelarena A,Kumar P,El-Sayed O,Elshabrawy HA,Epstein AL,Prabhakar BS
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.
PloS one
Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Jul 19 00:00:00 EDT 2016
Protective efficacy of the chimeric Staphylococcus aureus vaccine candidate IC in sepsis and pneumonia models.
Scientific reports
Yang L,Cai C,Feng Q,Shi Y,Zuo Q,Yang H,Jing H,Wei C,Zhuang Y,Zou Q,Zeng H
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Feb 11 00:00:00 EST 2016
Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells.
Nature communications
Göbel K,Pankratz S,Asaridou CM,Herrmann AM,Bittner S,Merker M,Ruck T,Glumm S,Langhauser F,Kraft P,Krug TF,Breuer J,Herold M,Gross CC,Beckmann D,Korb-Pap A,Schuhmann MK,Kuerten S,Mitroulis I,Ruppert C,Nolte MW,Panousis C,Klotz L,Kehrel B,Korn T,Langer HF,Pap T,Nieswandt B,Wiendl H,Chavakis T,Kleinschnitz C,Meuth SG
14-7311 was used in Flow cytometry/Cell sorting to study how immune activation by FXII is mediated by dendritic cells in a CD87-dependent manner, and involves alterations in intracellular cyclic AMP formation.
Wed May 18 00:00:00 EDT 2016
High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner.
Scientific reports
Polansky JK,Bahri R,Divivier M,Duitman EH,Vock C,Goyeneche-Patino DA,Orinska Z,Bulfone-Paus S
14-7311 was used in Flow cytometry/Cell sorting to analyse the in vivo potential of IL15 as an immune-regulator when available at different concentrations or delivery modes.
Fri Jan 29 00:00:00 EST 2016
Reprogramming the immunological microenvironment through radiation and targeting Axl.
Nature communications
Aguilera TA,Rafat M,Castellini L,Shehade H,Kariolis MS,Hui AB,Stehr H,von Eyben R,Jiang D,Ellies LG,Koong AC,Diehn M,Rankin EB,Graves EE,Giaccia AJ
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Dec 23 00:00:00 EST 2016
IL-15-dependent balance between Foxp3 and RORγt expression impacts inflammatory bowel disease.
Nature communications
Tosiek MJ,Fiette L,El Daker S,Eberl G,Freitas AA
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma.
Journal for immunotherapy of cancer
Patel MA,Kim JE,Theodros D,Tam A,Velarde E,Kochel CM,Francica B,Nirschl TR,Ghasemzadeh A,Mathios D,Harris-Bookman S,Jackson CC,Jackson C,Ye X,Tran PT,Tyler B,Coric V,Selby M,Brem H,Drake CG,Pardoll DM,Lim M
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Wed May 18 00:00:00 EDT 2016
Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.
Nature medicine
Alam MS,Gaida MM,Bergmann F,Lasitschka F,Giese T,Giese NA,Hackert T,Hinz U,Hussain SP,Kozlov SV,Ashwell JD
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that TCR-mediated activation of CD4+ TIL results in alternative p38 activation and production of pro-tumorigenic factors.
Sun Nov 01 00:00:00 EDT 2015
Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System.
Immunity
Guerrini MM,Okamoto K,Komatsu N,Sawa S,Danks L,Penninger JM,Nakashima T,Takayanagi H
14-7311-81 was used in Flow Cytometry to show that receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL) on T cells regulates C-C type chemokine ligand 20 (CCL20) production by astrocytes and T cell localization in the CNS.
Tue Dec 15 00:00:00 EST 2015
Identification of natural RORγ ligands that regulate the development of lymphoid cells.
Cell metabolism
Santori FR,Huang P,van de Pavert SA,Douglass EF,Leaver DJ,Haubrich BA,Keber R,Lorbek G,Konijn T,Rosales BN,Rozman D,Horvat S,Rahier A,Mebius RE,Rastinejad F,Nes WD,Littman DR
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Feb 03 00:00:00 EST 2015
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Nature immunology
Basu R,Whitley SK,Bhaumik S,Zindl CL,Schoeb TR,Benveniste EN,Pear WS,Hatton RD,Weaver CT
14-7311 was used in Functional assays to assess the ability of IL-1 to override retinoic acid-mediated expression of the transcription factor Foxp3 and induce protective TH17 cell responses.
Sun Mar 01 00:00:00 EST 2015
DNAM-1 controls NK cell activation via an ITT-like motif.
The Journal of experimental medicine
Zhang Z,Wu N,Lu Y,Davidson D,Colonna M,Veillette A
14-7311-81 was used in Flow cytometry/Cell sorting to investigate the mechanism by which DNAM-1 controls NK cell-mediated cytotoxicity and cytokine production.
Mon Nov 16 00:00:00 EST 2015
Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases.
The Journal of allergy and clinical immunology
Russell SL,Gold MJ,Reynolds LA,Willing BP,Dimitriu P,Thorson L,Redpath SA,Perona-Wright G,Blanchet MR,Mohn WW,Finlay BB,McNagny KM
14-7311 was used in Functional assays to assess the effect of perinatal exposure to antibiotics on the severity of Saccharopolyspora rectivirgula infection.
Thu Jan 01 00:00:00 EST 2015
Curing mice with large tumors by locally delivering combinations of immunomodulatory antibodies.
Clinical cancer research : an official journal of the American Association for Cancer Research
Dai M,Yip YY,Hellstrom I,Hellstrom KE
14-7311 was used in Flow cytometry/Cell sorting to assess immunologic and anti-tumour responses to the administration of various antibodies to various cancers.
Sun Mar 01 00:00:00 EST 2015
MHC-mismatched mixed chimerism augments thymic regulatory T-cell production and prevents relapse of EAE in mice.
Proceedings of the National Academy of Sciences of the United States of America
Wu L,Li N,Zhang M,Xue SL,Cassady K,Lin Q,Riggs AD,Zeng D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Dec 29 00:00:00 EST 2015
Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice.
Hypertension (Dallas, Tex. : 1979)
Yodoi K,Yamashita T,Sasaki N,Kasahara K,Emoto T,Matsumoto T,Kita T,Sasaki Y,Mizoguchi T,Sparwasser T,Hirata K
14-7311 was used in Flow cytometry/Cell sorting to suggest that Foxp3(+) Tregs may play a protective role in abdominal aortic aneurysm formation.
Wed Apr 01 00:00:00 EDT 2015
Single-Dose CpG Immunization Protects Against a Heterosubtypic Challenge and Generates Antigen-Specific Memory T Cells.
Frontiers in immunology
Vogel AJ,Brown DM
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jul 10 00:00:00 EDT 2015
Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.
Mucosal immunology
Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U
14-7311 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.
Sun Mar 01 00:00:00 EST 2015
Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis.
Mucosal immunology
Visekruna A,Linnerz T,Martinic V,Vachharajani N,Hartmann S,Harb H,Joeris T,Pfefferle PI,Hofer MJ,Steinhoff U
14-7311 was used in Flow cytometry/Cell sorting to investigate the role c-Rel plays in regulating innate lymphoid cells which induce anti-CD40-mediated innate colitis in mice.
Sun Mar 01 00:00:00 EST 2015
A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine.
Mucosal immunology
Dunne A,Mielke LA,Allen AC,Sutton CE,Higgs R,Cunningham CC,Higgins SC,Mills KH
14-7311 was used in Flow cytometry/Cell sorting to investigate the identification and characterisation of novel TLR2-activating lipoproteins from B. pertussis.
Fri May 01 00:00:00 EDT 2015
Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Mucosal immunology
Bertin S,Lozano-Ruiz B,Bachiller V,García-Martínez I,Herdman S,Zapater P,Francés R,Such J,Lee J,Raz E,González-Navajas JM
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that DUSP6 regulates CD4+ T-cell activation and differentiation by inhibiting TCR-dependent ERK1/2 activation.
Fri May 01 00:00:00 EDT 2015
CD39 Expression Identifies Terminally Exhausted CD8+ T Cells.
PLoS pathogens
Gupta PK,Godec J,Wolski D,Adland E,Yates K,Pauken KE,Cosgrove C,Ledderose C,Junger WG,Robson SC,Wherry EJ,Alter G,Goulder PJ,Klenerman P,Sharpe AH,Lauer GM,Haining WN
14-7311 was used in Flow cytometry/Cell sorting to compare the expression of CD39 by CD8+ T cells from healthy donors and subjects with chronic viral infections.
Thu Oct 01 00:00:00 EDT 2015
Differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma.
European journal of immunology
McAlees JW,Lajoie S,Dienger K,Sproles AA,Richgels PK,Yang Y,Khodoun M,Azuma M,Yagita H,Fulkerson PC,Wills-Karp M,Lewkowich IP
14-7311 was used in in vivo experiments to investigate the role of PD-1 family members in allergic asthma, showing differential control of CD4(+) T-cell subsets by the PD-1/PD-L1 axis.
Wed Apr 01 00:00:00 EDT 2015
Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.
Molecular medicine (Cambridge, Mass.)
Li CH,Lin MH,Chu SH,Tu PH,Fang CC,Yen CH,Liang PI,Huang JC,Su YC,Sytwu HK,Chen YM
14-7311 was used in Immunocytochemistry to investigate whether glycine N-methyltransferase plays an immunomodulatory role in the pathogenesis of experimental autoimmune encephalomyelitis.
Tue Mar 24 00:00:00 EDT 2015
γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice.
Journal of leukocyte biology
Mehta P,Nuotio-Antar AM,Smith CW
14-7311 was used in Flow cytometry/Cell sorting to reveal that isolated γδ T cells directly stimulated RAW264.7 macrophage TNF-α expression but did not stimulate inflammatory mediator expression in 3T3-L1 adipocytes.
Thu Jan 01 00:00:00 EST 2015
Caspase-1 independent viral clearance and adaptive immunity against mucosal respiratory syncytial virus infection.
Immune network
Shim YR,Lee HK
14-7311 was used in an ELISA assay to demonstrate that caspase-1 might not play a central role in the induction of Th1 and CTL immune responses to RSV.
Wed Apr 01 00:00:00 EDT 2015
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance.
Journal of immunology (Baltimore, Md. : 1950)
O'Hagan KL,Choi J,Pryshchep O,Chernoff J,Phee H
14-7311 was used in Flow cytometry/Cell sorting to show a novel role for the actin cytoskeletal remodeling protein, p21-activated kinase 2, in Treg development and homeostasis.
Sat Aug 15 00:00:00 EDT 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-7311 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.
Human vaccines & immunotherapeutics
Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon May 16 00:00:00 EDT 2016
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2016
Inadequate activation of the HBsAg-specific Th cells by APCs leads to hyporesponsiveness to HBsAg vaccine in B10.S mice.
Human vaccines & immunotherapeutics
Li X,Xu J,Lv Z,Wang J,Sun S,Zhu W,Wang B,He R,Qu D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Apr 19 00:00:00 EDT 2016
Immunogenicity and protective efficacy of DMT liposome-adjuvanted tuberculosis subunit CTT3H vaccine.
Human vaccines & immunotherapeutics
Teng X,Tian M,Li J,Tan S,Yuan X,Yu Q,Jing Y,Zhang Z,Yue T,Zhou L,Fan X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 11 00:00:00 EST 2016
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
The Journal of pharmacology and experimental therapeutics
Mangan PR,Su LJ,Jenny V,Tatum AL,Picarillo C,Skala S,Ditto N,Lin Z,Yang X,Cotter PZ,Shuster DJ,Song Y,Borowski V,Thomas RL,Heimrich EM,Devaux B,Das Gupta R,Carvajal I,McIntyre KW,Xie J,Zhao Q,Struthers M,Salter-Cid LM
14-7311 was used in Neutralization experiments to evaluate the effect of selective IL-23 and IL-17 inhibitors alone and in combination with in vitro and in vivo models of Th17-mediated autoimmunity.
Sat Aug 01 00:00:00 EDT 2015
Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.
Gene therapy
Rodriguez-Peña AB,Gomez-Rodriguez J,Kortum RL,Palmer DC,Yu Z,Guittard GC,Wohlfert EA,Silver PB,Misplon JA,Sommers CL,Feigenbaum L,Epstein SL,Caspi RR,Belkaid Y,Restifo NP,Samelson LE,Balagopalan L
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2015
Regulatory CD8(+)CD122 (+) T-cells predominate in CNS after treatment of experimental stroke in male mice with IL-10-secreting B-cells.
Metabolic brain disease
Bodhankar S,Chen Y,Lapato A,Vandenbark AA,Murphy SJ,Saugstad JA,Offner H
14-7311 was used in Immunofluorescence to demonstrate a major neuroprotective role for IL-10(+) B-cells in treating MCAO in male WT mice.
Sat Aug 01 00:00:00 EDT 2015
An atlas of mouse CD4(+) T cell transcriptomes.
Biology direct
Stubbington MJ,Mahata B,Svensson V,Deonarine A,Nissen JK,Betz AG,Teichmann SA
14-7311 was used in Flow cytometry/Cell sorting to show that hundreds of genes are regulated purely by alternative splicing to extend our knowledge of the role of post-transcriptional regulation in cell differentiation.
Fri Apr 03 00:00:00 EDT 2015
Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation.
PloS one
Derkow K,Krüger C,Dembny P,Lehnardt S
14-7311 was used in Flow cytometry/Cell sorting to investigate the crosstalk between γδ T cells and microglia activated by Toll-like receptors in the context of neuronal damage.
Tue May 17 00:00:00 EDT 2016
Mechanisms of immunity in post-exposure vaccination against Ebola virus infection.
PloS one
Bradfute SB,Anthony SM,Stuthman KS,Ayithan N,Tailor P,Shaia CI,Bray M,Ozato K,Bavari S
14-7311 was used in Functional assays to analyse the expression levels of various cytokines in the serum of mice given an Ebola virus-like particle.
Tue Feb 23 00:00:00 EST 2016
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Cell reports
Hermann-Kleiter N,Klepsch V,Wallner S,Siegmund K,Klepsch S,Tuzlak S,Villunger A,Kaminski S,Pfeifhofer-Obermair C,Gruber T,Wolf D,Baier G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Dec 08 00:00:00 EST 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Dec 08 00:00:00 EST 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Dec 08 00:00:00 EST 2015
Near-infrared photoactivatable control of Ca(2+) signaling and optogenetic immunomodulation.
eLife
He L,Zhang Y,Ma G,Tan P,Li Z,Zang S,Wu X,Jing J,Fang S,Zhou L,Wang Y,Huang Y,Hogan PG,Han G,Zhou Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Dec 08 00:00:00 EST 2015
A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.
PloS one
Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue May 24 00:00:00 EDT 2016
A Multiple Antigenic Peptide Mimicking Peptidoglycan Induced T Cell Responses to Protect Mice from Systemic Infection with Staphylococcus aureus.
PloS one
Wang XY,Huang ZX,Chen YG,Lu X,Zhu P,Wen K,Fu N,Liu BY
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue May 24 00:00:00 EDT 2016
SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression.
Nature communications
Shao L,Zhou HJ,Zhang H,Qin L,Hwa J,Yun Z,Ji W,Min W
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in ELISA
Tue Nov 24 00:00:00 EST 2015
The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells.
Immunity
Tang W,Wang H,Claudio E,Tassi I,Ha HL,Saret S,Siebenlist U
14-7311 was used in Flow cytometry/Cell sorting to investigate a T-cell-intrinsic function of the transcriptional regulator Bcl-3 in autoimmunity.
Thu Oct 16 00:00:00 EDT 2014
Antiviral drug ganciclovir is a potent inhibitor of microglial proliferation and neuroinflammation.
The Journal of experimental medicine
Ding Z,Mathur V,Ho PP,James ML,Lucin KM,Hoehne A,Alabsi H,Gambhir SS,Steinman L,Luo J,Wyss-Coray T
14-7311 was used in Flow cytometry/Cell sorting to suggest that the antiviral drug ganciclovir (GCV) may have beneficial effects in the CNS beyond its antiviral properties.
Mon Feb 10 00:00:00 EST 2014
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
EMBO molecular medicine
Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ
14-7311 was used in Functional assays to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.
Sat Feb 01 00:00:00 EST 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Western Blot
Tue Jul 01 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Western Blot
Tue Jul 01 00:00:00 EDT 2014
IL-17 drives psoriatic inflammation via distinct, target cell-specific mechanisms.
Proceedings of the National Academy of Sciences of the United States of America
Ha HL,Wang H,Pisitkun P,Kim JC,Tassi I,Tang W,Morasso MI,Udey MC,Siebenlist U
14-7311-81 was used in Flow cytometry/Cell sorting to identify critical roles of CIKS/Act1-mediated signalling in imiquimod-induced psoriatic inflammation, a mouse model that shares features with the human disease.
Tue Aug 19 00:00:00 EDT 2014
Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.
Cancer immunology research
Arnold JN,Magiera L,Kraman M,Fearon DT
14-7311 was used in Blocking experiments to investigate how pharmacologically targeting the HO-1 enzyme may improve cancer immunotherapy.
Sat Feb 01 00:00:00 EST 2014
A CD40-targeted peptide controls and reverses type 1 diabetes in NOD mice.
Diabetologia
Vaitaitis GM,Olmstead MH,Waid DM,Carter JR,Wagner DH
14-7311 was used in Flow cytometry/Cell sorting to develop small peptides based on the CD154 domain that interacts with CD40, but does not cause thrombotic events.
Sat Nov 01 00:00:00 EDT 2014
The Critical Role of IL-15-PI3K-mTOR Pathway in Natural Killer Cell Effector Functions.
Frontiers in immunology
Nandagopal N,Ali AK,Komal AK,Lee SH
14-7311 was used in Flow cytometry/Cell sorting to investigate whether the effect of IL-15 priming of NK cells can be extended to other cytokines, showing a critical role of the IL-15-PI3K-mTOR in NK effector functions.
Mon May 05 00:00:00 EDT 2014
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Mucosal immunology
Chan IH,Jain R,Tessmer MS,Gorman D,Mangadu R,Sathe M,Vives F,Moon C,Penaflor E,Turner S,Ayanoglu G,Chang C,Basham B,Mumm JB,Pierce RH,Yearley JH,McClanahan TK,Phillips JH,Cua DJ,Bowman EP,Kastelein RA,LaFace D
14-7311 was used in Flow cytometry/Cell sorting to reveal an explicit role for IL-23-mediated initiation of gut tumorigenesis and implicate a key role for IL-23R(+) ILC3 in the absence of overt cellular infiltrate recruitment.
Tue Jul 01 00:00:00 EDT 2014
Inhibition of the TRAIL death receptor by CMV reveals its importance in NK cell-mediated antiviral defense.
PLoS pathogens
Verma S,Loewendorf A,Wang Q,McDonald B,Redwood A,Benedict CA
14-7311 was used in Flow cytometry/Cell sorting to highlight the critical importance for CMV to have evolved a strategy to inhibit TRAIL-DR signaling to thwart NK-mediated defenses.
Fri Aug 01 00:00:00 EDT 2014
Microsphere priming facilitates induction of potent therapeutic T-cell immune responses against autochthonous liver cancers.
European journal of immunology
Brinkhoff B,Ostroumov D,Heemcke J,Woller N,Gürlevik E,Manns MP,Longerich T,Zender L,Harty JT,Kubicka S,Kühnel F,Wirth TC
14-7311-81 was used in Flow Cytometry to develop a prime-boost vaccination protocol based on the administration of antigen conjugated to poly-lactic-co-glycolic acid microspheres followed by booster vaccination with Listeria monocytogenes vectors.
Tue Apr 01 00:00:00 EDT 2014
IFN-γ regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1.
European journal of immunology
Medina-Echeverz J,Haile LA,Zhao F,Gamrekelashvili J,Ma C,Métais JY,Dunbar CE,Kapoor V,Manns MP,Korangy F,Greten TF
14-7311 was used in an ELISA assay to suggest that IFN-γ/ STAT1-dependent regulation of Bcl2a1 regulates survival and thereby suppressor function of granulocytic myeloid derived suppressor cells.
Fri Aug 01 00:00:00 EDT 2014
TLR2 engagement on CD4(+) T cells enhances effector functions and protective responses to Mycobacterium tuberculosis.
European journal of immunology
Reba SM,Li Q,Onwuzulike S,Ding X,Karim AF,Hernandez Y,Fulton SA,Harding CV,Lancioni CL,Nagy N,Rodriguez ME,Wearsch PA,Rojas RE
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity.
European journal of immunology
Mayer CT,Ghorbani P,Kühl AA,Stüve P,Hegemann M,Berod L,Gershwin ME,Sparwasser T
14-7311-81 was used in Flow Cytometry to study the mechanisms underlying why regulatory T cell-depletion fails to cause autoimmunity in adult Depletion of REGulatory T cells mice.
Wed Oct 01 00:00:00 EDT 2014
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells.
Cancer immunology, immunotherapy : CII
Kosaka A,Ohkuri T,Okada H
14-7311 was used in Flow cytometry/Cell sorting to evaluate the therapeutic effects and underlying mechanisms of a combination regimen with an agonist CD40 mAb and the COX-2 inhibitor celecoxib.
Fri Aug 01 00:00:00 EDT 2014
Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation.
Journal of leukocyte biology
Kurmaeva E,Bhattacharya D,Goodman W,Omenetti S,Merendino A,Berney S,Pizarro T,Ostanin DV
14-7311 was used in Blocking experiments to characterise the interplay between colitis-induced myeloid cells and the CD4 T cell response.
Mon Sep 01 00:00:00 EDT 2014
Colitogenic effector T cells: roles of gut-homing integrin, gut antigen specificity and γδ T cells.
Immunology and cell biology
Do JS,Visperas A,Freeman ML,Iwakura Y,Oukka M,Min B
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that T-cell colitogenicity is achieved through multiple processes, offering a therapeutic rationale by intervening these pathways.
Wed Jan 01 00:00:00 EST 2014
IL-12hi rapamycin-conditioned dendritic cells mediate IFN-γ-dependent apoptosis of alloreactive CD4+ T cells in vitro and reduce lethal graft-versus-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Stenger EO,Rosborough BR,Mathews LR,Ma H,Mapara MY,Thomson AW,Turnquist HR
14-7311 was used in an ELISA assay to test the hypothesis that IL-12(hi) dendritic cells generated in rapamycin, would facilitate IFN-γ-mediated apoptosis of alloreactive T cells and would reduce lethal graft-versus-host disease.
Sat Feb 01 00:00:00 EST 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-7311-81 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Olson MR,Seah SG,Cullen J,Greyer M,Edenborough K,Doherty PC,Bedoui S,Lew AM,Turner SJ
14-7311 was used in Flow cytometry/Cell sorting to investigate whether induction of CD4(+) Th responses postinfection are also dependent on CD4(+) T cell help.
Mon Dec 01 00:00:00 EST 2014
IFNαR signaling in effector but not regulatory T cells is required for immune dysregulation during type I IFN-dependent inflammatory disease.
Journal of immunology (Baltimore, Md. : 1950)
Srivastava S,Koch LK,Campbell DJ
14-7311 was used in Flow cytometry/Cell sorting to study how chronic IFN expression can drive inflammatory disease via its direct effects on effector, but not regulatory, T cells.
Mon Sep 15 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms.
F1000Research
Niebling J,E Rünker A,Schallenberg S,Kretschmer K,Kempermann G
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 06 00:00:00 EST 2020
Potential role of IL-17-producing iNKT cells in type 1 diabetes.
PloS one
Li S,Joseph C,Becourt C,Klibi J,Luce S,Dubois-Laforgue D,Larger E,Boitard C,Benlagha K
14-7311 was used in Flow cytometry/Cell sorting to investigate the status and potential role of iNKT17 in type 1 diabetes.
Thu Jan 22 00:00:00 EST 2015
Dysregulated cytokine production by dendritic cells modulates B cell responses in the NZM2410 mouse model of lupus.
PloS one
Sang A,Zheng YY,Yin Y,Dozmorov I,Li H,Hsu HC,Mountz JD,Morel L
14-7311 was used in Flow cytometry/Cell sorting to show that the lupus prone mice autoimmune genetic background induces the production of B cell-modulating inflammatory cytokines by dendritic cells.
Fri Apr 24 00:00:00 EDT 2015
RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Nature
Lukens JR,Vogel P,Johnson GR,Kelliher MA,Iwakura Y,Lamkanfi M,Kanneganti TD
14-7311 was used in Flow cytometry/Cell sorting to investigate how mutations in SHP-1 causes inflammatory disease, showing that RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3.
Thu Jun 13 00:00:00 EDT 2013
Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin.
Cell host & microbe
Hickman HD,Reynoso GV,Ngudiankama BF,Rubin EJ,Magadán JG,Cush SS,Gibbs J,Molon B,Bronte V,Bennink JR,Yewdell JW
14-7311 was used in Flow cytometry/Cell sorting to explore the spatiotemporal organization between antiviral immune cells and vaccinia virus-infected murine cells.
Wed Feb 13 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
14-7311 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100.
Blood
Leonhardt F,Grundmann S,Behe M,Bluhm F,Dumont RA,Braun F,Fani M,Riesner K,Prinz G,Hechinger AK,Gerlach UV,Dierbach H,Penack O,Schmitt-Gräff A,Finke J,Weber WA,Zeiser R
14-7311-81 was used in Flow Cytometry to identify negative regulation of GvHD-related neovascularization by miR-100.
Thu Apr 25 00:00:00 EDT 2013
CD40L expression permits CD8+ T cells to execute immunologic helper functions.
Blood
Frentsch M,Stark R,Matzmohr N,Meier S,Durlanik S,Schulz AR,Stervbo U,Jürchott K,Gebhardt F,Heine G,Reuter MA,Betts MR,Busch D,Thiel A
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of CD40L in CD8+ T cells, showing that expression permits CD8+ T cells to execute immunologic helper functions.
Thu Jul 18 00:00:00 EDT 2013
IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis.
The Journal of clinical investigation
Huber M,Heink S,Pagenstecher A,Reinhard K,Ritter J,Visekruna A,Guralnik A,Bollig N,Jeltsch K,Heinemann C,Wittmann E,Buch T,Prazeres da Costa O,Brüstle A,Brenner D,Mak TW,Mittrücker HW,Tackenberg B,Kamradt T,Lohoff M
14-7311 was used in Magnetic cell separation to investigate the role of IL-17-producing CD8+ T cells in multiple sclerosis using a murine model.
Tue Jan 01 00:00:00 EST 2013
Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T cells through splenocyte interactions.
Kidney international
Hu J,Zhang L,Wang N,Ding R,Cui S,Zhu F,Xie Y,Sun X,Wu D,Hong Q,Li Q,Shi S,Liu X,Chen X
14-7311 was used in Flow cytometry/Cell sorting to study how mesenchymal stem cells ameliorate ischemic acute kidney injury by inducing regulatory T cells through interactions with splenocytes.
Sun Sep 01 00:00:00 EDT 2013
The Nlrp3 inflammasome regulates acute graft-versus-host disease.
The Journal of experimental medicine
Jankovic D,Ganesan J,Bscheider M,Stickel N,Weber FC,Guarda G,Follo M,Pfeifer D,Tardivel A,Ludigs K,Bouazzaoui A,Kerl K,Fischer JC,Haas T,Schmitt-Gräff A,Manoharan A,Müller L,Finke J,Martin SF,Gorka O,Peschel C,Ruland J,Idzko M,Duyster J,Holler E,French LE,Poeck H,Contassot E,Zeiser R
14-7311 was used in Flow cytometry/Cell sorting to study the establishment and role of the Nlrp3 inflammasome in acute graft-versus-host disease.
Mon Sep 23 00:00:00 EDT 2013
Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation.
The Journal of experimental medicine
Mielke LA,Jones SA,Raverdeau M,Higgs R,Stefanska A,Groom JR,Misiak A,Dungan LS,Sutton CE,Streubel G,Bracken AP,Mills KH
14-7311 was used in Flow cytometry/Cell sorting to provide novel insights into the molecular events controlling IL-22 transcription.
Mon Jun 03 00:00:00 EDT 2013
Skin-draining lymph node priming is sufficient to induce sterile immunity against pre-erythrocytic malaria.
EMBO molecular medicine
Obeid M,Franetich JF,Lorthiois A,Gego A,Grüner AC,Tefit M,Boucheix C,Snounou G,Mazier D
14-7311 was used in Neutralization experiments to investigate whether sterile protection can be obtained in the absence of priming by infected hepatocytes.
Fri Feb 01 00:00:00 EST 2013
An intact immune system is required for the anticancer activities of histone deacetylase inhibitors.
Cancer research
West AC,Mattarollo SR,Shortt J,Cluse LA,Christiansen AJ,Smyth MJ,Johnstone RW
14-7311 was used in Flow cytometry/Cell sorting to clarify the role of the immune system in mediating the efficacy of HDACi against tumours, showing that an intact immune system is required for anticancer activity.
Sun Dec 15 00:00:00 EST 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Loss of the TGFβ-activating integrin αvβ8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity.
PLoS pathogens
Worthington JJ,Klementowicz JE,Rahman S,Czajkowska BI,Smedley C,Waldmann H,Sparwasser T,Grencis RK,Travis MA
14-7311 was used in Flow cytometry/Cell sorting to describe a novel cellular and molecular pathway involved in the development of chronic intestinal parasite infection.
Mon May 26 00:00:00 EDT 2014
Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection.
Journal of virology
Trujillo JA,Fleming EL,Perlman S
14-7311 was used in Flow cytometry/Cell sorting to examine the role of CCL2 during virus infection, showing that CCL2 expression in the CNS results in a dysregulated immune response after coronavirus infection.
Fri Mar 01 00:00:00 EST 2013
Aged mice exhibit a severely diminished CD8 T cell response following respiratory syncytial virus infection.
Journal of virology
Fulton RB,Weiss KA,Pewe LL,Harty JT,Varga SM
14-7311 was used in Flow cytometry/Cell sorting to investigate the extent to which CD8 T cell response to respiratory syncytial virus is altered with age, showing that age severely diminishes response.
Sun Dec 01 00:00:00 EST 2013
CD4+ T cells develop antiretroviral cytotoxic activity in the absence of regulatory T cells and CD8+ T cells.
Journal of virology
Manzke N,Akhmetzyanova I,Hasenkrug KJ,Trilling M,Zelinskyy G,Dittmer U
14-7311 was used in Flow cytometry/Cell sorting to investigate how both Tregs and CD8(+) T cells influence the cytotoxic activity of conventional CD4(+) T cells during an acute retroviral infection.
Sat Jun 01 00:00:00 EDT 2013
IL-4 induces a suppressive IL-10-producing CD8+ T cell population via a Cdkn2a-dependent mechanism.
Journal of leukocyte biology
Zhao Y,Zhao H,Sun Y,Hao J,Qi X,Zhou X,Wu Z,Wang P,Kaech SM,Weaver CT,Flavell RA,Zhao L,Yao Z,Yin Z
14-7311 was used in Functional assays to define a population of IL-10-producing CD8(+) T cells that are induced by IL-4.
Sun Dec 01 00:00:00 EST 2013
Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.
Human vaccines & immunotherapeutics
Wu B,Zou Q,Hu Y,Wang B
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Toll-like receptor 7 mediates early innate immune responses to malaria.
Infection and immunity
Baccarella A,Fontana MF,Chen EC,Kim CC
14-7311 was used in Flow cytometry/Cell sorting to investigate other MYD88-dependent receptors contributing to antimalarial responses, showing that toll-like receptor 7 mediates early innate immune responses to malaria.
Sun Dec 01 00:00:00 EST 2013
Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
Infection and immunity
Scalfone LK,Nel HJ,Gagliardo LF,Cameron JL,Al-Shokri S,Leifer CA,Fallon PG,Appleton JA
14-7311 was used in an ELISA assay to investigate the role in immunity of innate receptors for potential pathogen- or danger-associated molecular patterns.
Mon Apr 01 00:00:00 EDT 2013
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis.
The Journal of biological chemistry
Zhong MC,Veillette A
14-7311 was used in Flow cytometry/Cell sorting to investigate how SAP plays an essential role in CIA because of Fyn-independent and Fyn-dependent effects on TFH cells and, possibly, other T cell types.
Fri Nov 01 00:00:00 EDT 2013
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
Lymphocytes with cytotoxic activity induce rapid microtubule axonal destabilization independently and before signs of neuronal death.
ASN neuro
Miller NM,Shriver LP,Bodiga VL,Ray A,Basu S,Ahuja R,Jana A,Pahan K,Dittel BN
14-7311 was used in Functional assays to demonstrate that CD4 Th1, CD4 Th17, CD8 as well as natural killer cells induce neuronal damage via the induction of microtubule axonal destabilization.
Wed Feb 06 00:00:00 EST 2013
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
Journal of neuroinflammation
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
14-7311 was used in Flow cytometry/Cell sorting to suggest that agents (for example antibodies) that can target and neutralise PD-L1/2 may have therapeutic potential for treatment of human stroke.
Mon Sep 09 00:00:00 EDT 2013
PD-L1 enhances CNS inflammation and infarct volume following experimental stroke in mice in opposition to PD-1.
Journal of neuroinflammation
Bodhankar S,Chen Y,Vandenbark AA,Murphy SJ,Offner H
14-7311 was used in Flow cytometry/Cell sorting to suggest that agents (for example antibodies) that can target and neutralise PD-L1/2 may have therapeutic potential for treatment of human stroke.
Mon Sep 09 00:00:00 EDT 2013
Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Nature communications
Yao C,Hirata T,Soontrapa K,Ma X,Takemori H,Narumiya S
14-7311 was used in Functional assays to investigate the role of cAMP in Th1 differentiation, showing that prostaglandin E2 promotes differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.
Tue Oct 22 00:00:00 EDT 2013
IL-21 is required for optimal antibody production and T cell responses during chronic Toxoplasma gondii infection.
PloS one
Stumhofer JS,Silver JS,Hunter CA
14-7311 was used in Flow cytometry/Cell sorting to identify a key role for IL-21 in shaping the humoral and cellular response to Toxoplasma gondii.
Mon Dec 09 00:00:00 EST 2013
Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo.
PloS one
Duarte JH,Di Meglio P,Hirota K,Ahlfors H,Stockinger B
14-7311 was used in Flow cytometry/Cell sorting to study how the immuno-modulatory effect of TCDD administration for EAE is not the consequence of de novo Treg generation, but the inhibition of Th17 cell differentiation.
Tue Aug 12 00:00:00 EDT 2014
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions.
Nature
Yoshizaki A,Miyagaki T,DiLillo DJ,Matsushita T,Horikawa M,Kountikov EI,Spolski R,Poe JC,Leonard WJ,Tedder TF
14-7311 was used in Flow cytometry/Cell sorting to investigate how B10-cell IL-10 production and regulation of antigen-specific immune responses are controlled in vivo.
Thu Nov 08 00:00:00 EST 2012
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice.
Nature
Devkota S,Wang Y,Musch MW,Leone V,Fehlner-Peach H,Nadimpalli A,Antonopoulos DA,Jabri B,Chang EB
14-7311 was used in Flow cytometry/Cell sorting to show that different dietary fat change the conditions for microbial assemblage in the digestive system in a T helper 1 cell dependent manner.
Thu Jul 05 00:00:00 EDT 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-7311 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-7311 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.
Blood
Tewalt EF,Cohen JN,Rouhani SJ,Guidi CJ,Qiao H,Fahl SP,Conaway MR,Bender TP,Tung KS,Vella AT,Adler AJ,Chen L,Engelhard VH
14-7311 was used in Functional assays to demonstrate that LECs mediate deletion only via programmed cell death-1 (PD-1) ligand 1.
Thu Dec 06 00:00:00 EST 2012
CD28 ligation increases macrophage suppression of T-cell proliferation.
Cellular & molecular immunology
Silberman D,Bucknum A,Bartlett T,Composto G,Kozlowski M,Walker A,Werda A,Cua J,Sharpe AH,Somerville JE,Riggs JE
14-7311 was used in Functional assays to investigate the ability of exogenous T-cell costimulation to recover the peritoneal T-cell response.
Sun Jul 01 00:00:00 EDT 2012
Increased protection from vaccinia virus infection in mice genetically prone to lymphoproliferative disorders.
Journal of virology
Seedhom MO,Mathurin KS,Kim SK,Welsh RM
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2012
Treatment with targeted vesicular stomatitis virus generates therapeutic multifunctional anti-tumor memory CD4 T cells.
Cancer gene therapy
Gao Y,Whitaker-Dowling P,Griffin JA,Bergman I
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2012
Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.
Journal of immunology (Baltimore, Md. : 1950)
Kwon MJ,Ma J,Ding Y,Wang R,Sun Z
14-7311 was used in Functional assays to investigate the function of PKC-θ in Th17 differentiation.
Fri Jun 15 00:00:00 EDT 2012
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses.
Journal of immunology (Baltimore, Md. : 1950)
Shankar SP,Wilson MS,DiVietro JA,Mentink-Kane MM,Xie Z,Wynn TA,Druey KM
14-7311 was used in Flow cytometry/Cell sorting to show that RGS16 constrains pulmonary inflammation by regulating chemokine-induced T cell trafficking.
Fri Jun 15 00:00:00 EDT 2012
Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Ramalingam R,Larmonier CB,Thurston RD,Midura-Kiela MT,Zheng SG,Ghishan FK,Kiela PR
14-7311 was used in Neutralization experiments to demonstrate that TGF-β signaling in DCs is critical in the control of autoimmunity through both Treg-dependent and -independent mechanisms.
Mon Oct 15 00:00:00 EDT 2012
Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi C,Papadopoulos G,Gudino CV,Weinberg EO,Barth KR,Madrigal AG,Chen Y,Ning H,LaValley M,Gibson FC,Hamilton JA,Genco CA
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2012
Evaluation of Lassa virus vaccine immunogenicity in a CBA/J-ML29 mouse model.
Vaccine
Goicochea MA,Zapata JC,Bryant J,Davis H,Salvato MS,Lukashevich IS
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Tue Feb 14 00:00:00 EST 2012
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
Published figure using IFN gamma monoclonal antibody (Product # 14-7311-81) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function.
Scientific reports
Chang RA,Miller SD,Longnecker R
14-7311 was used in an ELISpot assay to investigate the Epstein-Barr virus as a possible etiological agent involved in multiple sclerosis.
Mon Feb 25 00:00:00 EST 2013
Epigenetic regulation of beta2-adrenergic receptor expression in T(H)1 and T(H)2 cells.
Brain, behavior, and immunity
McAlees JW,Smith LT,Erbe RS,Jarjoura D,Ponzio NM,Sanders VM
14-7311 was used in Flow cytometry/Cell sorting to sugest that epigenetic changes maintain expression of the β2AR on TH1 cells, but repress expression on TH2 cells.
Tue Mar 01 00:00:00 EST 2011
Epigenetic regulation of beta2-adrenergic receptor expression in T(H)1 and T(H)2 cells.
Brain, behavior, and immunity
McAlees JW,Smith LT,Erbe RS,Jarjoura D,Ponzio NM,Sanders VM
14-7311 was used in Flow cytometry/Cell sorting to sugest that epigenetic changes maintain expression of the β2AR on TH1 cells, but repress expression on TH2 cells.
Tue Mar 01 00:00:00 EST 2011
Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.
The Journal of experimental medicine
Wei J,Loke P,Zang X,Allison JP
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of B7x in maintaining peripheral tolerance and protecting from CD4 T cell-mediated autoimmunity.
Mon Aug 01 00:00:00 EDT 2011
Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity.
The Journal of experimental medicine
Sotolongo J,España C,Echeverry A,Siefker D,Altman N,Zaias J,Santaolalla R,Ruiz J,Schesser K,Adkins B,Fukata M
14-7311 was used in Neutralization experiments to demonstrate a previously unknown role of TRIF in host resistance to Gram-negative enteropathogens, which may lead to strategies for combating enteric infections.
Mon Dec 19 00:00:00 EST 2011
A role for leukocyte-derived IL-1RA in DC homeostasis revealed by increased susceptibility of IL-1RA-deficient mice to cutaneous leishmaniasis.
The Journal of investigative dermatology
Kautz-Neu K,Kostka SL,Dinges S,Iwakura Y,Udey MC,von Stebut E
14-7311 was used in Flow cytometry/Cell sorting to suggest that in addition to effects on Th education, IL-1α/β signalling also modulates DC homeostasis with increased signalling, leading to down-modulation of IL-12 synthesis and worsened disease outcome after infection with Leishmania major.
Mon Aug 01 00:00:00 EDT 2011
A LysM and SH3-domain containing region of the Listeria monocytogenes p60 protein stimulates accessory cells to promote activation of host NK cells.
PLoS pathogens
Schmidt RL,Filak HC,Lemon JD,Potter TA,Lenz LL
14-7311 was used in Flow cytometry/Cell sorting to demonstrate an immune stimulating function for a bacterial LysM domain-containing polypeptide.
Tue Nov 01 00:00:00 EDT 2011
Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.
European journal of immunology
Goudy KS,Johnson MC,Garland A,Li C,Samulski RJ,Wang B,Tisch R
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of IL-2 in the regulation of FoxP3(+) T reg cells in NOD mice.
Sun May 01 00:00:00 EDT 2011
T cell-intrinsic factors contribute to the differential ability of CD8+ T cells to rapidly secrete IFN-γ in the absence of antigen.
Journal of immunology (Baltimore, Md. : 1950)
Bou Ghanem EN,Nelson CC,D'Orazio SE
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that the microenvironment in L. monocytogenes-infected BALB/c mice is sufficient to induce responsive CD8(+) T cells to rapidly secrete IFN-γ.
Tue Feb 01 00:00:00 EST 2011
Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds ND,Lukacs NW,Long N,Karpus WJ
14-7311 was used in Flow cytometry/Cell sorting to suggest a role for Delta-like ligand 4 regulation of experimental autoimmune encephalomyelitis pathogenesis.
Thu Sep 01 00:00:00 EDT 2011
TLR4 signaling via MyD88 and TRIF differentially shape the CD4+ T cell response to Porphyromonas gingivalis hemagglutinin B.
Journal of immunology (Baltimore, Md. : 1950)
Gaddis DE,Michalek SM,Katz J
14-7311 was used in Flow cytometry/Cell sorting to investigate how the stimulation of dendritic cells with recombinant haemagglutinin B affects the activation and differentiation of T cells in mice.
Sun May 15 00:00:00 EDT 2011
High TCR stimuli prevent induced regulatory T cell differentiation in a NF-κB-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Molinero LL,Miller ML,Evaristo C,Alegre ML
14-7311 was used in Flow cytometry/Cell sorting to identify that NF-κB helps T cells control their differentiation fate in a cell-intrinsic manner and prevents peripheral iTreg development.
Fri Apr 15 00:00:00 EDT 2011
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
14-7311 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
MHC class I-deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I-sufficient environment.
The Journal of experimental medicine
Elliott JM,Wahle JA,Yokoyama WM
14-7311 was used in Flow cytometry/Cell sorting to investigate whether licensing is developmentally determined in the bone marrow, showing that MHC class I ligands are not absolutely required for licensing.
Mon Sep 27 00:00:00 EDT 2010
Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery.
Plant biotechnology journal
Davoodi-Semiromi A,Schreiber M,Nalapalli S,Verma D,Singh ND,Banks RK,Chakrabarti D,Daniell H
14-7311 was used in Flow cytometry/Cell sorting to further investigate use of chloroplast-derived vaccines against major diseases.
Mon Feb 01 00:00:00 EST 2010
Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells.
PLoS pathogens
Wilson DC,Grotenbreg GM,Liu K,Zhao Y,Frickel EM,Gubbels MJ,Ploegh HL,Yap GS
14-7311 was used in Flow cytometry/Cell sorting to identify a novel H-2K(b)-restricted CTL population specific for the Toxoplasma antigen tgd057.
Fri Mar 19 00:00:00 EDT 2010
Antitumor activity of type I and type III interferons in BNL hepatoma model.
Cancer immunology, immunotherapy : CII
Abushahba W,Balan M,Castaneda I,Yuan Y,Reuhl K,Raveche E,de la Torre A,Lasfar A,Kotenko SV
14-7311 was used in Neutralization experiments to show the antitumor activities of IFN-lambda against hepatoma, in combination with HCV and HBV antiviral activities.
Thu Jul 01 00:00:00 EDT 2010
T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice.
Journal of virology
Zhao J,Zhao J,Perlman S
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of T cells in clearance of severe acute respiratory syndrome coronavirus.
Wed Sep 01 00:00:00 EDT 2010
Polyinosinic-polycytidylic acid treatment of Friend retrovirus-infected mice improves functional properties of virus-specific T cells and prevents virus-induced disease.
Journal of immunology (Baltimore, Md. : 1950)
Gibbert K,Dietze KK,Zelinskyy G,Lang KS,Barchet W,Kirschning CJ,Dittmer U
14-7311 was used in Flow cytometry/Cell sorting to investigate the mode of action of poly(I:C) in antiretroviral immunotherapy.
Mon Nov 15 00:00:00 EST 2010
A role for granzyme M in TLR4-driven inflammation and endotoxicosis.
Journal of immunology (Baltimore, Md. : 1950)
Anthony DA,Andrews DM,Chow M,Watt SV,House C,Akira S,Bird PI,Trapani JA,Smyth MJ
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that granzymes should be considered as potential key regulators of inflammation.
Sun Aug 01 00:00:00 EDT 2010
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Zhu Y,Ju S,Chen E,Dai S,Li C,Morel P,Liu L,Zhang X,Lu B
14-7311 was used in Flow cytometry/Cell sorting to define T-bet and Eomes as critical regulators of T cell-mediated immune responses against tumours.
Wed Sep 15 00:00:00 EDT 2010
Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
Journal of immunology (Baltimore, Md. : 1950)
Matsushita T,Horikawa M,Iwata Y,Tedder TF
14-7311 was used in Flow cytometry/Cell sorting to investigate how the regulatory functions of B10 cells and FoxP3(+) Tregs overlap or influence EAE immunopathogenesis independently.
Sun Aug 15 00:00:00 EDT 2010
Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.
Blood
Ryu SJ,Jung KM,Yoo HS,Kim TW,Kim S,Chang J,Choi EY
14-7311 was used in Flow cytometry/Cell sorting to provide insight into the control of minor H antigen-specific CD8 T-cell responses, to maximize the graft-versus-leukemia response.
Thu Apr 30 00:00:00 EDT 2009
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury.
The Journal of clinical investigation
Heymann F,Meyer-Schwesinger C,Hamilton-Williams EE,Hammerich L,Panzer U,Kaden S,Quaggin SE,Floege J,Gröne HJ,Kurts C
14-7311 was used in Flow cytometry/Cell sorting to investigate the role of several immune cell types within tubulointerstitial mononuclear cell infiltrates in the progression of kidney disease.
Fri May 01 00:00:00 EDT 2009
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
The Journal of experimental medicine
Doisne JM,Bartholin L,Yan KP,Garcia CN,Duarte N,Le Luduec JB,Vincent D,Cyprian F,Horvat B,Martel S,Rimokh R,Losson R,Benlagha K,Marie JC
14-7311 was used in Flow cytometry/Cell sorting to show that TGF-beta controls the differentiation program of iNKT cells.
Mon Jun 08 00:00:00 EDT 2009
Cytokine-induced memory-like natural killer cells.
Proceedings of the National Academy of Sciences of the United States of America
Cooper MA,Elliott JM,Keyel PA,Yang L,Carrero JA,Yokoyama WM
14-7311 was used in Flow cytometry/Cell sorting to identify an ability of innate immune cells to retain an intrinsic memory of prior activation.
Tue Feb 10 00:00:00 EST 2009
Coxsackievirus B3 inhibits antigen presentation in vivo, exerting a profound and selective effect on the MHC class I pathway.
PLoS pathogens
Kemball CC,Harkins S,Whitmire JK,Flynn CT,Feuer R,Whitton JL
14-7311 was used in Flow cytometry/Cell sorting to evaluate in vitro and in vivo antigen presentation by coxsackievirus B3, showing that it inhibits antigen presentation in vivo.
Thu Oct 01 00:00:00 EDT 2009
Toll-like receptor 4 deficiency increases disease and mortality after mouse hepatitis virus type 1 infection of susceptible C3H mice.
Journal of virology
Khanolkar A,Hartwig SM,Haag BA,Meyerholz DK,Harty JT,Varga SM
14-7311 was used in Flow cytometry/Cell sorting to demonstrate that TLR4 plays an important role in respiratory CoV pathogenesis.
Tue Sep 01 00:00:00 EDT 2009
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.
Journal of immunology (Baltimore, Md. : 1950)
Kohu K,Ohmori H,Wong WF,Onda D,Wakoh T,Kon S,Yamashita M,Nakayama T,Kubo M,Satake M
14-7311 was used in Functional assays to investigate the role of Runx3 in Th1 and Th2 cells.
Tue Dec 15 00:00:00 EST 2009
NF-kappa B1 p105 regulates T cell homeostasis and prevents chronic inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Chang M,Lee AJ,Fitzpatrick L,Zhang M,Sun SC
14-7311 was used in Blocking experiments to investigate the physiological functions of NF-kappaB inhibitors, showing that p105 regulates T cell homeostasis and prevents chronic inflammation.
Sun Mar 01 00:00:00 EST 2009
Antiangiogenesis immunotherapy induces epitope spreading to Her-2/neu resulting in breast tumor immunoediting.
Breast cancer (Dove Medical Press)
Seavey MM,Paterson Y
14-7311 was used in an ELISpot assay to test whether directing the immune response to a normal cell type required for tumor growth and survival could provide a more stable immunotherapeutic target.
Tue Dec 24 00:00:00 EST 2013
Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines.
The Journal of investigative dermatology
Mori T,Kabashima K,Yoshiki R,Sugita K,Shiraishi N,Onoue A,Kuroda E,Kobayashi M,Yamashita U,Tokura Y
14-7311 was used in Immunohistochemistry to suggests that IFN-gamma causes upregulation of keratinocyte Th1 production and downregulation of Langerhans cells Th2 chemokine production.
Tue Jul 01 00:00:00 EDT 2008
Tentative T cells: memory cells are quick to respond, but slow to divide.
PLoS pathogens
Whitmire JK,Eam B,Whitton JL
14-7311 was used in Flow cytometry/Cell sorting to evaluate whether memory T cells initiate cell division much more rapidly than their naïve counterparts upon encountering the relevant pathogen.
Fri Apr 11 00:00:00 EDT 2008
Th17 cells undergo Fas-mediated activation-induced cell death independent of IFN-gamma.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Xu G,Zhang L,Roberts AI,Shi Y
Tue Jul 01 00:00:00 EDT 2008
IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells.
Proceedings of the National Academy of Sciences of the United States of America
Kimura A,Naka T,Kishimoto T
Tue Jul 17 00:00:00 EDT 2007
The role of NKG2D signaling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40.
Journal of virology
Pinto AK,Jamieson AM,Raulet DH,Hill AB
14-7311 was used in Flow cytometry/Cell sorting to investigate role of NKG2D signalling in inhibition of cytotoxic T-lymphocyte lysis by the Murine cytomegalovirus immunoevasin m152/gp40.
Thu Nov 01 00:00:00 EDT 2007
Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation.
Molecular cell
Wegener E,Oeckinghaus A,Papadopoulou N,Lavitas L,Schmidt-Supprian M,Ferch U,Mak TW,Ruland J,Heissmeyer V,Krappmann D
14-7311 was used in Flow cytometry/Cell sorting to investigate the physiological function of antigen-induced phosphorylation of Bcl10.
Fri Jul 07 00:00:00 EDT 2006
IFN-gamma decreases CTL generation by limiting IL-2 production: A feedback loop controlling effector cell production.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Hidalgo LG,Urmson J,Halloran PF
Fri Apr 01 00:00:00 EST 2005
