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Osenses

5HT6 R Polyclonal Antibody

2 References

View all (14) HTR6 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Product Details

OSS00204W-100UL

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:2,000

Immunohistochemistry (IHC)

1:300-1:2,000

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Not Applicable

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 400-440 of mouse 5HT6R conjugated to blue carrier protein was used as the antigen

View immunogen

Conjugate

Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: 5HT6R receptor.

Target Information

This is one of the several different receptors for 5-hydroxytryptamine, a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The DNA sequence and biological annotation of human chromosome 1.

Nature

Gregory SG,Barlow KF,McLay KE,Kaul R,Swarbreck D,Dunham A,Scott CE,Howe KL,Woodfine K,Spencer CC,Jones MC,Gillson C,Searle S,Zhou Y,Kokocinski F,McDonald L,Evans R,Phillips K,Atkinson A,Cooper R,Jones C,Hall RE,Andrews TD,Lloyd C,Ainscough R,Almeida JP,Ambrose KD,Anderson F,Andrew RW,Ashwell RI,Aubin K,Babbage AK,Bagguley CL,Bailey J,Beasley H,Bethel G,Bird CP,Bray-Allen S,Brown JY,Brown AJ,Buckley D,Burton J,Bye J,Carder C,Chapman JC,Clark SY,Clarke G,Clee C,Cobley V,Collier RE,Corby N,Coville GJ,Davies J,Deadman R,Dunn M,Earthrowl M,Ellington AG,Errington H,Frankish A,Frankland J,French L,Garner P,Garnett J,Gay L,Ghori MR,Gibson R,Gilby LM,Gillett W,Glithero RJ,Grafham DV,Griffiths C,Griffiths-Jones S,Grocock R,Hammond S,Harrison ES,Hart E,Haugen E,Heath PD,Holmes S,Holt K,Howden PJ,Hunt AR,Hunt SE,Hunter G,Isherwood J,James R,Johnson C,Johnson D,Joy A,Kay M,Kershaw JK,Kibukawa M,Kimberley AM,King A,Knights AJ,Lad H,Laird G,Lawlor S,Leongamornlert DA,Lloyd DM,Loveland J,Lovell J,Lush MJ,Lyne R,Martin S,Mashreghi-Mohammadi M,Matthews L,Matthews NS,McLaren S,Milne S,Mistry S,Moore MJ,Nickerson T,O'Dell CN,Oliver K,Palmeiri A,Palmer SA,Parker A,Patel D,Pearce AV,Peck AI,Pelan S,Phelps K,Phillimore BJ,Plumb R,Rajan J,Raymond C,Rouse G,Saenphimmachak C,Sehra HK,Sheridan E,Shownkeen R,Sims S,Skuce CD,Smith M,Steward C,Subramanian S,Sycamore N,Tracey A,Tromans A,Van Helmond Z,Wall M,Wallis JM,White S,Whitehead SL,Wilkinson JE,Willey DL,Williams H,Wilming L,Wray PW,Wu Z,Coulson A,Vaudin M,Sulston JE,Durbin R,Hubbard T,Wooster R,Dunham I,Carter NP,McVean G,Ross MT,Harrow J,Olson MV,Beck S,Rogers J,Bentley DR,Banerjee R,Bryant SP,Burford DC,Burrill WD,Clegg SM,Dhami P,Dovey O,Faulkner LM,Gribble SM,Langford CF,Pandian RD,Porter KM,Prigmore E

Thu May 18 00:00:00 UTC 2006

Cloning of the mouse 5-HT6 serotonin receptor and mutagenesis studies of the third cytoplasmic loop.

Brain research. Molecular brain research

Kohen R,Fashingbauer LA,Heidmann DE,Guthrie CR,Hamblin MW

Wed Jun 20 00:00:00 UTC 2001

Bioinformatics

Protein Aliases: 5-HT-6; 5-HT6 receptor; 5-hydroxytryptamine receptor 6; Serotonin receptor 6

Gene Aliases: 5-HT6; Htr6

UniProt ID: (Mouse) Q9R1C8

Entrez Gene ID: (Mouse) 15565

Function(s)

signal transducer activity G-protein coupled receptor activity G-protein coupled serotonin receptor activity protein binding G-protein coupled receptor

Process(es)

signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger serotonin receptor signaling pathway learning negative regulation of glutamate secretion negative regulation of gamma-aminobutyric acid secretion positive regulation of gamma-aminobutyric acid secretion negative regulation of acetylcholine secretion, neurotransmission cerebral cortex cell migration positive regulation of TOR signaling positive regulation of dopamine secretion long-term synaptic potentiation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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