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Product Details
66423-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3G4G7
Immunogen
PDIA3 Fusion Protein Ag8741 (161-505 aa encoded by BC014433)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DDSFSEAHS EFLKAASNLR DNYRFAHTNV ESLVNEYDDN GEGIILFRPS HLTNKFEDKT VAYTEQKMTS GKIKKFIQEN IFGICPHMTE DNKDLIQGKD LLIAYYDVDY EKNAKGSNYW RNRVMMVAKK FLDAGHKLNF AVASRKTFSH ELSDFGLEST AGEIPVVAIR TAKGEKFVMQ EEFSRDGKAL ERFLQDYFDG NLKRYLKSEP IPESNDGPVK VVVAENFDEI VNNENKDVLI EFYAPWCGHC KNLEPKYKEL GEKLSKDPNI VIAKMDATAN DVPSPYEVRG FPTIYFSPAN KKLNPKKYEG GRELSDFISY LQREATNPPV IQEEKPKKKK KAQEDL (161-505 aa encoded by BC014433)
Target Information
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; endoplasmic reticulum P58; endoplasmic reticulum protein; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; epididymis secretory protein Li 269; epididymis secretory sperm binding protein Li 93n; ER p57; ER protein 57; ER protein 60; ER-60 protease; ERp 57; ERp60; glucose regulated protein, 58 kDa; glucose regulated protein, 58kDa; GRP 57; GRP 58; HIP-70; oxidoreductase ERp57; p58; PDIA 3; phospholipase C, alpha; phospholipase C-alpha; PI PLC; protein disulfide isomerase associated 3; protein disulfide isomerase family A, member 3; protein disulfide isomerase-associated 3; Protein disulfide-isomerase A3; Q-2
Gene Aliases: 58kDa; ER60; Erp; ERP57; ERP60; ERp61; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PDI; PDI-Q2; PDIA3; PI-PLC; PLC[a]; Plca
UniProt ID: (Human) P30101, (Mouse) P27773, (Rat) P11598
Entrez Gene ID: (Human) 2923, (Mouse) 14827, (Rat) 29468
antigen processing and presentation of peptide antigen via MHC class I
protein folding
proteolysis
protein import into nucleus
protein retention in ER lumen
signal transduction
protein folding in endoplasmic reticulum
response to endoplasmic reticulum stress
cell redox homeostasis
oxidation-reduction process
positive regulation of extrinsic apoptotic signaling pathway
cellular response to vitamin D
positive regulation of protein folding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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