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Proteintech
DDX3 Recombinant Rabbit Monoclonal Antibody (5C12)
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Product Details
81903-1-RR
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
Mammalian cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5C12
Immunogen
Recombinant protein
Conjugate
Unconjugated
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: DLERGCHLLV ATPGRLVDMM ERGKIGLDFC KYLVLDEADR MLDMGFEPQI RRIVEQDTMP PKGVRHTMMF SATFPKEIQM LARDFLDEYI FLAVGRVGST SENITQKVVW VEESDKRSFL LDLLNATGKD SLTLVFVETK KGADSLEDFL YHEGYACTSI HGDRSQRDRE EALHQFRSGK SPILVATAVA ARGLDISNVK HVINFDLPSD IEEYVHRIGR TGRVGNLGLA TSFFNERNIN ITKDLLDLLV EAKQEVPSWL ENMAYEHHYK GSSRGRSKSS RFSGGFGARD YRQSSGASSS SFSSSRASSS RSGGGGHGSS RGFGGGGYGG FYNSDGYGGN YNSQGVDWWG N
Target Information
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent RNA helicase DDX3X; CAP-Rf; D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 3; D1Pas1-related sequence 2; DBX; DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 3; DEAD box protein 3, X-chromosomal; DEAD box RNA helicase DEAD3; DEAD box, X isoform; DEAD-box protein 3 (DEAD-box RNA helicase DEAD3) (mDEAD3) (Embryonic RNA helicase) (D1PAS1 related sequence 2); DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked; DEAD/H box-3; Embryonic RNA helicase; fibroblast growth factor inducible 14; Helicase-like protein 2; HLP2; mDEAD3
Gene Aliases: CAP-Rf; D1Pas1-rs2; DBX; DDX14; DDX3; DDX3X; Dead3; Erh; Fin14; HLP2; MRX102
UniProt ID: (Human) O00571, (Mouse) Q62167
Entrez Gene ID: (Human) 1654, (Rat) 317335, (Mouse) 13205
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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