Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Invitrogen
Promotions
View available promotion(s)
Promo Code: P5877545 Don't miss out: buy 3, only pay for 2 From June 2-13 take advantage of our 3 for 2 promotion. Whether you are restocking essentials or trying something new, now is a great time to get more for your money!. Learn more
Promo Code: RPUZZ25 Stock up on essentials to piece your discovery together Until June 27, save up to $650 and get an exclusive lab-themed hidden-object puzzle. Learn more
FIGURE: 1 / 2
Antibody detects endogenous levels of total ACAP2.
ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Arf GAP with coiled coil, ANK repeat and PH domains 2; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; centaurin beta2; centaurin, beta 2; Centaurin-beta-2; Cnt-b2
Gene Aliases: 4832442G16; 9530039J15Rik; ACAP2; CENTB2; CNT-B2; KIAA0041; mKIAA0041
UniProt ID: (Human) Q15057, (Mouse) Q6ZQK5, (Rat) Q5FVC7
Entrez Gene ID: (Human) 23527, (Mouse) 78618, (Rat) 619382
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support