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Bethyl Laboratories
ACC1/ACC-alpha Polyclonal Antibody
FIGURE: 1 / 2
ACC1/ACC-alpha Antibody (A300-987A) in WB
Detection of human and mouse ACC1/ACC-alpha by western blot (h&m) and immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded), HEK293T (T; 50 µg) and mouse NIH 3T3 (M; 50 µg) cells. Antibodies: Affinity purified rabbit anti-ACC1/ACC-alpha antibody (Product # A300-987A) used for WB at 0.1 µg/mL (A and B). ACC1/ACC-alpha was immunoprecipitated by rabbit anti-ACC1/ACC-alpha antibody (Product # A300-986A), which recognizes an upstream epitope. Detection: Chemiluminescence with expos... View More
Product Details
A300-987A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2333 and the C-terminus (residue 2383) of human acetyl-Coenzyme A carboxylase alpha.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat, Sheep and Bovine
Target Information
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACC-alpha; ACC1; Acetyl-CoA carboxylase 1; Acetyl-Coenzyme A carboxylase alpha; EC 6.3.4.14; EC 6.4.1.2
Gene Aliases: ACAC; ACACA; ACACAD; ACC; ACC1; ACCA
UniProt ID: (Human) Q13085
Entrez Gene ID: (Human) 31
tissue homeostasis
acetyl-CoA metabolic process
fatty acid biosynthetic process
biotin metabolic process
carnitine shuttle
positive regulation of cellular metabolic process
long-chain fatty-acyl-CoA biosynthetic process
multicellular organismal protein metabolic process
protein homotetramerization
lipid homeostasis
cellular response to prostaglandin E stimulus
malonyl-CoA biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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