Product References
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly.
The Journal of experimental medicine
Onnis A,Andreano E,Cassioli C,Finetti F,Della Bella C,Staufer O,Pantano E,Abbiento V,Marotta G,D'Elios MM,Rappuoli R,Baldari CT
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Mon Feb 06 00:00:00 EST 2023
SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly.
The Journal of experimental medicine
Onnis A,Andreano E,Cassioli C,Finetti F,Della Bella C,Staufer O,Pantano E,Abbiento V,Marotta G,D'Elios MM,Rappuoli R,Baldari CT
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Mon Feb 06 00:00:00 EST 2023
SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19.
Research (Washington, D.C.)
Ma X,Liang J,Zhu G,Bhoria P,Shoara AA,MacKeigan DT,Khoury CJ,Slavkovic S,Lin L,Karakas D,Chen Z,Prifti V,Liu Z,Shen C,Li Y,Zhang C,Dou J,Rousseau Z,Zhang J,Ni T,Lei X,Chen P,Wu X,Shaykhalishahi H,Mubareka S,Connelly KA,Zhang H,Rotstein O,Ni H
MA5-32307 was used in Western Blotting to show that the RBD can bind platelets partially though αIIbβ3 and induce platelet activation and clearance, which may contribute to thrombosis and thrombocytopenia observed in COVID-19 and VITT.
Thu May 25 00:00:00 EDT 2023
ACE-2, TMPRSS2, and Neuropilin-1 Receptor Expression on Human Brain Astrocytes and Pericytes and SARS-CoV-2 Infection Kinetics.
International journal of molecular sciences
Malik JR,Acharya A,Avedissian SN,Byrareddy SN,Fletcher CV,Podany AT,Dyavar SR
MA5-32307 was used in Immunocytochemistry to show that SARS-CoV-2 cellular entry receptor expression and in vitro" viral kinetics in astrocytes and pericytes."
Thu May 11 00:00:00 EDT 2023
COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses.
EBioMedicine
Chen Y,Song W,Li C,Wang J,Liu F,Ye Z,Ren P,Tong Y,Li J,Ou Z,Lee AC,Cai JP,Wong BH,Chan JF,Yuen KY,Zhang AJ,Chu H
MA5-32307 was used in Immunohistochemistry to suggest that COVID-19 mRNA vaccination enhances host innate antiviral responses in obesity which protect the DIO mice to a certain degree when adaptive immunity is suboptimal.
Wed Mar 01 00:00:00 EST 2023
Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs.
PLoS biology
Loo L,Waller MA,Moreno CL,Cole AJ,Stella AO,Pop OT,Jochum AK,Ali OH,Denes CE,Hamoudi Z,Chung F,Aggarwal A,Low JKK,Patel K,Siddiquee R,Kang T,Mathivanan S,Mackay JP,Jochum W,Flatz L,Hesselson D,Turville S,Neely GG
MA5-32307 was used in Immunocytochemistry, Immunohistochemistry, Western Blot, Flow Cytometry to conclude that LRRC15 is a novel SARS-CoV-2 spike-binding receptor that can help control viral load and regulate antiviral and antifibrotic transcriptional programs in the context of COVID-19 infection.
Wed Feb 01 00:00:00 EST 2023
Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor.
Scientific reports
Mahalingam G,Arjunan P,Periyasami Y,Dhyani AK,Devaraju N,Rajendiran V,Christopher AC,Kt RD,Dhanasingh I,Thangavel S,Murugesan M,Moorthy M,Srivastava A,Marepally S
MA5-32307 was used in Western Blotting to provide a precise method to evaluate the binding interactions between spike sub-lineages to hACE2 receptors.
Tue May 30 00:00:00 EDT 2023
More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro.
Virus research
Semple SL,Alkie TN,Jenik K,Warner BM,Tailor N,Kobasa D,DeWitte-Orr SJ
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Immunocytochemistry
Tue Nov 01 00:00:00 EDT 2022
Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model.
Journal of virus eradication
Endo Y,Hickerson BT,Ilyushina NA,Mohan N,Peng H,Takeda K,Donnelly RP,Wu WJ
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation.
Molecular biology of the cell
Lu Y,Zhu Q,Fox DM,Gao C,Stanley SA,Luo K
MA5-32307 was used in Western Blotting to suggest that ACE2 down-regulation represents an important mechanism underlying SARS-CoV-2-associated pathology, and blocking this process could be a promising therapeutic strategy.
Thu Dec 01 00:00:00 EST 2022
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Cell
Daniloski Z,Jordan TX,Wessels HH,Hoagland DA,Kasela S,Legut M,Maniatis S,Mimitou EP,Lu L,Geller E,Danziger O,Rosenberg BR,Phatnani H,Smibert P,Lappalainen T,tenOever BR,Sanjana NE
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Thu Jan 07 00:00:00 EST 2021
Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells.
Cell
Daniloski Z,Jordan TX,Wessels HH,Hoagland DA,Kasela S,Legut M,Maniatis S,Mimitou EP,Lu L,Geller E,Danziger O,Rosenberg BR,Phatnani H,Smibert P,Lappalainen T,tenOever BR,Sanjana NE
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Thu Jan 07 00:00:00 EST 2021
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.
Antiviral research
Kashyap T,Murray J,Walker CJ,Chang H,Tamir S,Hou B,Shacham S,Kauffman MG,Tripp RA,Landesman Y
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Sun Aug 01 00:00:00 EDT 2021
Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo.
Antiviral research
Kashyap T,Murray J,Walker CJ,Chang H,Tamir S,Hou B,Shacham S,Kauffman MG,Tripp RA,Landesman Y
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Western Blot
Sun Aug 01 00:00:00 EDT 2021
Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract.
Journal of virology
Alfi O,Yakirevitch A,Wald O,Wandel O,Izhar U,Oiknine-Djian E,Nevo Y,Elgavish S,Dagan E,Madgar O,Feinmesser G,Pikarsky E,Bronstein M,Vorontsov O,Jonas W,Ives J,Walter J,Zakay-Rones Z,Oberbaum M,Panet A,Wolf DG
MA5-32307 was used in Immunohistochemistry to investigate viral susceptibility and early patterns of local mucosal innate immune response in the authentic milieu of the human respiratory tract. SARS-CoV-2 productively infected the nasal turbinate tissues, predominantly targeting respiratory epithelial cells, with a rapid increase in tissue-associated viral subgenomic mRNA and secretion of infectious viral progeny.
Thu Jun 24 00:00:00 EDT 2021
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Journal of translational medicine
Hernandez JJ,Beaty DE,Fruhwirth LL,Lopes Chaves AP,Riordan NH
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Immunocytochemistry
Wed Apr 14 00:00:00 EDT 2021
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Journal of translational medicine
Hernandez JJ,Beaty DE,Fruhwirth LL,Lopes Chaves AP,Riordan NH
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Immunocytochemistry
Wed Apr 14 00:00:00 EDT 2021
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Journal of translational medicine
Hernandez JJ,Beaty DE,Fruhwirth LL,Lopes Chaves AP,Riordan NH
Published figure using ACE2 recombinant monoclonal antibody (Product # MA5-32307) in Immunocytochemistry
Wed Apr 14 00:00:00 EDT 2021
Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2.
Communications biology
Brady M,McQuaid C,Solorzano A,Johnson A,Combs A,Venkatraman C,Rahman A,Leyva H,Kwok WE,Wood RW,Deane R
MA5-32307 was used in Immunohistochemistry to show that SARS-CoV-2 spike protein had a body-wide biodistribution, slow regional elimination, except for the liver, which showed an accumulation, and differential organ uptake.
Mon Nov 22 00:00:00 EST 2021
Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry.
ACS infectious diseases
Firpo MR,Mastrodomenico V,Hawkins GM,Prot M,Levillayer L,Gallagher T,Simon-Loriere E,Mounce BC
MA5-32307 was used in Immunocytochemistry to show coronavirus relies on polyamines for replication and thus could be a novel drug target.
Fri Jun 11 00:00:00 EDT 2021
Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology.
bioRxiv : the preprint server for biology
Stewart CA,Gay CM,Ramkumar K,Cargill KR,Cardnell RJ,Nilsson MB,Heeke S,Park EM,Kundu ST,Diao L,Wang Q,Shen L,Xi Y,Zhang B,Della Corte CM,Fan Y,Kundu K,Gao B,Avila K,Pickering CR,Johnson FM,Zhang J,Kadara H,Minna JD,Gibbons DL,Wang J,Heymach JV,Byers LA
MA5-32307 was used in Western Blotting to investigate the expression and regulation of ACE2 and TMPRSS2, which are the mian co-factors for SARS-CoV-2 enter host cells.
Thu Jan 28 00:00:00 EST 2021
Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication.
The European respiratory journal
Chen M,Shen W,Rowan NR,Kulaga H,Hillel A,Ramanathan M,Lane AP
MA5-32307 was used in Immunohistochemistry to determine the location of angiotensin-converting enzyme 2(ACE-2) in human nasal and tracheal specimens.
Tue Sep 01 00:00:00 EDT 2020
Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication.
The European respiratory journal
Chen M,Shen W,Rowan NR,Kulaga H,Hillel A,Ramanathan M,Lane AP
MA5-32307 was used in Immunohistochemistry to determine the location of angiotensin-converting enzyme 2(ACE-2) in human nasal and tracheal specimens.
Tue Sep 01 00:00:00 EDT 2020
Human Induced Pluripotent Stem Cell-Derived Lung Epithelial System for SARS-CoV-2 Infection Modeling and Its Potential in Drug Repurposing.
Stem cells and development
Surendran H,Nandakumar S,Pal R
MA5-32307 was used in Immunocytochemistry-immunoflourescence to show preliminary data on how human induced pluripotent stem cells-derived lung epithelial cell system could emerge as a relevant and sensitive platform for modeling SARS-CoV-2 infection and drug screening.
Sun Nov 01 00:00:00 EDT 2020
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies.
Frontiers in pharmacology
Suresh V,Parida D,Minz AP,Sethi M,Sahoo BS,Senapati S
MA5-32307 was used in Western Blot and Immunohistochemistry to analyze the tissue-specific expression pattern of angiotensin-converting enzyme 2, a proven functional receptor for SARS-CoV-2 in different organs of the hamster.
Fri Feb 12 00:00:00 EST 2021
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies.
Frontiers in pharmacology
Suresh V,Parida D,Minz AP,Sethi M,Sahoo BS,Senapati S
MA5-32307 was used in Western Blot and Immunohistochemistry to analyze the tissue-specific expression pattern of angiotensin-converting enzyme 2, a proven functional receptor for SARS-CoV-2 in different organs of the hamster.
Fri Feb 12 00:00:00 EST 2021
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies.
Frontiers in pharmacology
Suresh V,Parida D,Minz AP,Sethi M,Sahoo BS,Senapati S
MA5-32307 was used in Western Blot and Immunohistochemistry to analyze the tissue-specific expression pattern of angiotensin-converting enzyme 2, a proven functional receptor for SARS-CoV-2 in different organs of the hamster.
Fri Feb 12 00:00:00 EST 2021
Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies.
Frontiers in pharmacology
Suresh V,Parida D,Minz AP,Sethi M,Sahoo BS,Senapati S
MA5-32307 was used in Western Blot and Immunohistochemistry to analyze the tissue-specific expression pattern of angiotensin-converting enzyme 2, a proven functional receptor for SARS-CoV-2 in different organs of the hamster.
Fri Feb 12 00:00:00 EST 2021