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Immunogen sequence: YGTMVFVRSF LVGEAARALS KACTIAIRYS AVRHQSEMKP GEPEPQILDF QTQQYKLFPL LATAYAFQFV GAYMKETYHR INEGIGQGDL SELPELHALT AGLKAFTSWT ANTGIEACRM ACGGHGYSHC SGLPNIYVNF TPSCTFEGEN TVMMLQTARF LMKSYDQVHS GKLVCGMVSY LNDLPSQRIQ PQQVAVWPTM VDINSPESLT EAYKLRAARL VEIAAKNLQK EVIHRKSKEV AWNLTSVDLV RASEAHCHYV VVKLFSEKLL KIQDKAIQAV LRSLCLLYSL YGISQNAGDF LQGSIMTEPQ ITQVNQRVKE LLTLIRSDAV ALVDAFDFQD VTLGSVLGRY DGNVYENLFE WAKNSPLNKA EVHESYKHLK SLQSKL
The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ACO; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; Palmitoyl-CoA oxidase; Peroxisomal acyl-coenzyme A oxidase 1; Peroxisomal fatty acyl-CoA oxidase; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase; SCOX; Straight-chain acyl-CoA oxidase
Gene Aliases: ACOX; ACOX1; AOX; D130055E20Rik; PALMCOX; Paox; RATACOA1; SCOX
UniProt ID: (Human) Q15067, (Rat) P07872, (Mouse) Q9R0H0
Entrez Gene ID: (Human) 51, (Rat) 50681, (Mouse) 11430
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