Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MCHKNGFPQEG GITAAFLQKR KLRLSKNHRP ARAKVTEHVR GTRPGRATAG PAASTRAAGS LFFDRWGNRG PAGCRGSSHL PQQLKFTTSD
Highest antigen sequence identity to the following orthologs - mouse 30%, rat 28%.
Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amino enhancer of split; Amino-terminal enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; TLE family member 5; TLE family member 5, transcriptional modulator
Gene Aliases: AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5; TLE5
UniProt ID: (Human) Q08117
Entrez Gene ID: (Human) 166
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