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            • Primary Antibodies ›
            • AIPL1 Antibodies

            Invitrogen

            AIPL1 Polyclonal Antibody

            View all (29) AIPL1 antibodies
            Datasheet
            Protocols
            Questions & Answers
            Catalog # PA5-109372
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            Price (USD)
            487.00
            100 µL
             
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            Cite AIPL1 Polyclonal Antibody

            • Antibody Testing Data (3)
            Application
            AIPL1 Antibody in Immunocytochemistry (ICC/IF)
            Group 53 Created with Sketch.

            FIGURE: 1 / 3

            AIPL1 Antibody (PA5-109372) in ICC/IF

            Immunofluorescence analysis of AIPL1 in Y79 cells. Samples were incubated with AIPL1 Polyclonal antibody (Product # PA5-109372) using a dilution of 1:100. Blue: DAPI for nuclear staining.
            View Product

            AIPL1 Antibody in Immunocytochemistry (ICC/IF)
            AIPL1 Antibody in Immunocytochemistry (ICC/IF)
            AIPL1 Antibody in Western Blot (WB)

            Product Details

            PA5-109372

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:500-1:2,000
            -

            Immunocytochemistry (ICC/IF)

            1:50-1:100
            -

            ELISA (ELISA)

            1 µg/mL
            -
            Product Specifications

            Species Reactivity

            Human, Mouse

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Recombinant fusion protein containing a sequence corresponding to amino acids 1-384 of human AIPL1 (NP_055151.3).
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            1.25 mg/mL

            Purification

            Affinity Chromatography

            Storage buffer

            PBS, pH 7.3, with 50% glycerol

            Contains

            0.02% sodium azide

            Storage conditions

            -20°C, Avoid Freeze/Thaw Cycles

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            RRID

            AB_2854783

            Product Specific Information

            Immunogen sequence: MDAALLLNVE GVKKTILHGG TGELPNFITG SRVIFHFRTM KCDEERTVID DSRQVGQPMH IIIGNMFKLE VWEILLTSMR VHEVAEFWCD TIHTGVYPIL SRSLRQMAQG KDPTEWHVHT CGLANMFAYH TLGYEDLDEL QKEPQPLVFV IELLQVDAPS DYQRETWNLS NHEKMKAVPV LHGEGNRLFK LGRYEEASSK YQEAIICLRN LQTKEKPWEV QWLKLEKMIN TLILNYCQCL LKKEEYYEVL EHTSDILRHH PGIVKAYYVR ARAHAEVWNE AEAKADLQKV LELEPSMQKA VRRELRLLEN RMAEKQEEER LRCRNMLSQG ATQPPAEPPT EPPAQSSTEP PAEPPTAPSA ELSAGPPAEP ATEPPPSPGH SLQH

            Target Information

            Aipl1 was initially identified as a protein implicated in Leber congenital amaurosis (LCA), an autosomal recessive disorder thought to be caused by the abnormal development of photoreceptors. Aipl1 is a tetratricopeptide repeat protein that is highly homologous to ARA9, a protein involved in the HSP90-mediated nuclear translocation and transactivation of the aryl hydrocarbon receptor. Aipl1 has also been found to function as part of a chaperone heterocomplex, interacting with Hsp90 and Hsp70. Aipl1 also associates with the cell cycle regulator NUB1. It is thought that Aipl1 cooperates with Hsp70 but not Hsp90 to suppress the formation of NUB1 inclusions, and these interactions are necessary in the normal photoreceptor maturation, as mutations that lead to LCA also compromise the interactions with the Hsp chaperones. At least three isoforms of Aipl1 are known to exist.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: aryl hydrocarbon receptor interacting protein-like 1; Aryl-hydrocarbon-interacting protein-like 1

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            Gene Aliases: A930007I01Rik; AIPL1; AIPL2; LCA4

            View more View less

            UniProt ID: (Human) Q9NZN9, (Mouse) Q924K1

            View more View less

            Entrez Gene ID: (Human) 23746, (Mouse) 114230

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            Function(s)

            farnesylated protein binding protein binding unfolded protein binding chaperone

            Process(es)

            retina homeostasis protein folding visual perception phototransduction, visible light protein farnesylation regulation of cGMP metabolic process negative regulation of apoptotic process
            It has to be done as per old AB suggested Products section.
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