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Immunogen sequence: IPITEAMRN DIIARICGED GQVDPNCFVL AQSIVFSAME QEHFSEFLRS HHFCKYQIEV LTSGTVYLAD ILFCESALFY FSEYMEKEDA VNILQFWLAA DNFQSQLAAK KGQYDGQEAQ NDAMILYDKY FSLQATHPLG FDDVVRLEIE SNICREGGPL PNCFTTPLRQ AWTTMEKVFL PGFLSSNLYY KYLNDLIHSV RGDEFLGGNV SLTAPGSVGP PDESHPGSSD SSASQSSVKK ASIKILKNFD EAIIVDAASL DPESLYQRTY AGKMTFGRVS DLGQFIRESE PEPDVRKSKG SMFSQAMKKW VQGNTDEAQE ELAWKIAKMI VSDIMQQAQY DQPLEKSTKL (314-663 aa encoded by BC017055)
The A-kinase anchor proteins are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein interacts with both the type I and type II regulatory subunits of PKA; therefore, it is a dual-specific AKAP. This protein is highly enriched in mitochondria. It contains RGS domains, in addition to a PKA-RII subunit-binding domain. The mitochondrial localization and the presence of RGS domains may have important implications for the function of this protein in PKA and G protein signal transduction.
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Protein Aliases: A kinase (PRKA) anchor protein 10; A kinase anchor protein 10; A kinase anchor protein 10, mitochondrial; A-kinase anchor protein 10, mitochondrial; AKAP-10; D-AKAP-2; Dual specific A kinase anchoring protein 2; Dual specificity A kinase-anchoring protein 2; MGC9414; mitochondrial A kinase PPKA anchor protein 10; PRKA10; protein kinase A anchoring protein 10; Protein kinase A-anchoring protein 10
Gene Aliases: 1500031L16Rik; AKAP-10; AKAP10; B130049N18Rik; D-AKAP-2; D-AKAP2; PRKA10
UniProt ID: (Human) O43572, (Mouse) O88845
Entrez Gene ID: (Human) 11216, (Rat) 360540, (Mouse) 56697
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