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            • Primary Antibodies ›
            • AKAP13 Antibodies

            Bethyl Laboratories

            AKAP13/AKAP-Lbc Polyclonal Antibody

            View all (11) AKAP13 antibodies
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            Cite AKAP13/AKAP-Lbc Polyclonal Antibody

            • Antibody Testing Data (1)
            Application
            AKAP13/AKAP-Lbc Antibody in Western Blot (WB)
            Group 53 Created with Sketch.

            FIGURE: 1 / 1

            AKAP13/AKAP-Lbc Antibody (A301-404A) in WB

            Detection of human AKAP13/AKAP-Lbc by western blot and immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-AKAP13/AKAP-Lbc antibody (Product # A301-404A) used for WB at 0.04 µg/mL (A) and 0.1 µg/mL (B) and used for IP at 3 µg/mg lysate. AKAP13/AKAP-Lbc was also immunoprecipitated by rabbit anti-AKAP13/AKAP-Lbc antibody A301-403A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 10 seconds (... View More
            View Product

            AKAP13/AKAP-Lbc Antibody in Western Blot (WB)

            Product Details

            A301-404A

            Applications
            Tested Dilution
            Publications

            Western Blot (WB)

            1:2,000-1:10,000
            -

            Immunoprecipitation (IP)

            2-5 µg/mg lysate
            -
            Product Specifications

            Species Reactivity

            Human

            Host/Isotype

            Rabbit / IgG

            Class

            Polyclonal

            Type

            Antibody

            Immunogen

            Region between residue 2754 and 2804 of human A kinase (PRKA) anchor protein 13.
            View immunogen

            Conjugate

            Unconjugated

            Form

            Liquid

            Concentration

            0.20 mg/mL

            Purification

            Antigen affinity chromatography

            Storage buffer

            TBS, pH 7.0 to 8.0, with 0.1% BSA

            Contains

            0.09% sodium azide

            Storage conditions

            4°C

            Shipping conditions

            Ambient (domestic); Wet ice (international)

            Product Specific Information

            The recommended shelf life for this product is 1 year from date of receipt.

            Target Information

            The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms containing c-terminal dbl oncogene homology (DH) and pleckstrin homology (PH) domains. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, function as protein kinase A-anchoring proteins and, in addition, enhance ligand-dependent activity of estrogen receptors alpha and beta.

            For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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            Cite this product

            Bioinformatics

            Protein Aliases: A kinase (PRKA) anchor protein 13; A-kinase anchor protein 13; A-kinase anchoring protein; AKAP-13; AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; LBC oncogene; Lymphoid blast crisis oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; p47; PRKA13; Protein kinase A-anchoring protein 13

            View more View less

            Gene Aliases: AKAP-13; AKAP-Lbc; AKAP13; ARHGEF13; BRX; c-lbc; HA-3; HT31; LBC; p47; PRKA13; PROTO-LB; PROTO-LBC

            View more View less

            UniProt ID: (Human) Q12802

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            Entrez Gene ID: (Human) 11214

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            Function(s)

            cAMP-dependent protein kinase activity signal transducer activity MAP-kinase scaffold activity guanyl-nucleotide exchange factor activity Rho guanyl-nucleotide exchange factor activity protein binding Rho GTPase binding protein complex scaffold metal ion binding protein kinase A binding

            Process(es)

            protein phosphorylation G-protein coupled receptor signaling pathway heart development regulation of cardiac muscle hypertrophy positive regulation of Rho protein signal transduction intracellular signal transduction positive regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of GTPase activity regulation of protein kinase activity regulation of small GTPase mediated signal transduction nuclear export cardiac muscle cell differentiation regulation of sarcomere organization bone development adrenergic receptor signaling pathway adrenergic receptor signaling pathway involved in heart process regulation of glucocorticoid mediated signaling pathway
            It has to be done as per old AB suggested Products section.
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            If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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