Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AKT1 kinase; AKT1m; Akt1m protein; AKT3 kinase; C-AKT; EC 2.7.11.1; murine thymoma viral (v-akt) oncogene homolog 1; PKB; PKB alpha; PKB gamma; Protein kinase Akt-3; Protein kinase B; Protein kinase B alpha; Protein kinase B gamma; protein kinase B, gamma; protein kinase B-alpha; Proto-oncogene c-Akt; rac protein kinase alpha; RAC protein kinase alpha RAC-PK alpha; RAC-alpha serine/threonine-protein kinase; RAC-gamma serine/threonine protein kinase; RAC-gamma serine/threonine-protein kinase; RAC-PK-alpha; RAC-PK-gamma; related to A and C kinases; serine-threonine protein kinase; STK-2; Thymoma viral proto-oncogene; thymoma viral proto-oncogene 1; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene 3; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); v-akt murine thymoma viral oncogene-like protein 1
Gene Aliases: AI851531; AKT; AKT1; AKT3; CWS6; D930002M15Rik; MPPH; MPPH2; Nmf350; PKB; PKB-ALPHA; PKB-GAMMA; PKB/Akt; PKBalpha; PKBG; PRKBA; PRKBG; RAC; RAC-ALPHA; RAC-gamma; RAC-PK-gamma; STK-2
UniProt ID: (Human) P31749, (Human) Q9Y243, (Mouse) P31750, (Rat) P47196, (Rat) Q63484, (Mouse) Q9WUA6
Entrez Gene ID: (Human) 207, (Human) 10000, (Rabbit) 100353706, (Mouse) 11651, (Rat) 24185, (Rat) 29414, (Mouse) 23797
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support