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Product Details
PA5-54564
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ALAD. Recombinant protein control fragment (Product #RP-93004).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637829
Product Specific Information
Immunogen sequence: VLIFGVPSRV PKDERGSAAD SEESPAIEAI HLLRKTFPNL LVACDVCLCP YTSHGHCGLL SENGAFRAEE SRQRLAEVAL AYA
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALADH; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehydratase; Porphobilinogen synthase; testicular tissue protein Li 95
Gene Aliases: ALAD; ALADH; PBGS
UniProt ID: (Human) P13716
Entrez Gene ID: (Human) 210
response to hypoxia
protoporphyrinogen IX biosynthetic process
heme biosynthetic process
response to oxidative stress
response to herbicide
response to iron ion
response to zinc ion
response to aluminum ion
response to ionizing radiation
response to vitamin B1
response to selenium ion
response to activity
response to cobalt ion
response to lipopolysaccharide
response to vitamin E
response to drug
response to amino acid
response to ethanol
response to arsenic-containing substance
response to cadmium ion
response to mercury ion
protein homooligomerization
response to glucocorticoid
response to methylmercury
response to platinum ion
response to fatty acid
cellular response to lead ion
cellular response to interleukin-4
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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