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Proteintech

ALDH1B1 Polyclonal Antibody

11 References

View all (10) ALDH1B1 antibodies

Datasheet

Protocols

Questions & Answers

Tech Support

Catalog # 15560-1-AP

Precio (EUR)

437,00

150 µL

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Datasheet

Protocols

Questions & Answers

Tech Support

Antibody Testing Data (8)

Application

ALDH1B1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 8

ALDH1B1 Antibody (15560-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 15560-1-AP (ALDH1B1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ALDH1B1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ALDH1B1 Antibody in Immunoprecipitation (IP)

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Product Details

15560-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ALDH1B1 Fusion Protein Ag7144 (168-517 aa encoded by BC001619)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.18 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: FCFTRHEPV GVCGQIIPWN FPLVMQGWKL APALATGNTV VMKVAEQTPL SALYLASLIK EAGFPPGVVN IITGYGPTAG AAIAQHMDVD KVAFTGSTEV GHLIQKAAGD SNLKRVTLEL GGKSPSIVLA DADMEHAVEQ CHEALFFNMG QCCCAGSRTF VEESIYNEFL ERTVEKAKQR KVGNPFELDT QQGPQVDKEQ FERVLGYIQL GQKEGAKLLC GGERFGERGF FIKPTVFGGV QDDMRIAKEE IFGPVQPLFK FKKIEEVVER ANNTRYGLAA AVFTRDLDKA MYFTQALQAG TVWVNTYNIV TCHTPFGGFK ESGNGRELGE DGLKAYTEVK TVTIKVPQKN S (168-517 aa encoded by BC001619)

Target Information

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. Alcohol drinking habits and cardiovascular disease risk factors may be associated with ALDH gene variants. ALDH1B1 (Aldehyde dehydrogenase family 1 member B1), also known as ALDH5 or ALDHX (Aldehyde dehydrogenase X, mitochondrial), is a 517 amino acid mitochondrial protein that is expressed in the liver, testis and to a lesser extent in brain. ALDH1B1 belongs to the aldehyde dehydrogenase family and may play a major role in ethanol detoxification.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Hepatitis B virus X protein induces ALDH2 ubiquitin-dependent degradation to enhance alcoholic steatohepatitis.

Gastroenterology report

Zhou H,Wan S,Luo Y,Liu H,Jiang J,Guo Y,Xiao J,Wu B

Tue Mar 07 00:00:00 UTC 2023

Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.

Journal of the science of food and agriculture

Zhao W,Peng D,Li W,Chen S,Liu B,Huang P,Wu J,Du B,Li P

Thu Dec 01 00:00:00 UTC 2022

Effect of different types of muscle activity on the gene and protein expression of ALDH family members in C57BL/6J mouse skeletal muscle.

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

Jee E,Tamura Y,Kouzaki K,Kotani T,Nakazato K

Fri Jul 01 00:00:00 UTC 2022

Aldehyde dehydrogenase 2 deficiency promotes skeletal muscle atrophy in aged mice.

American journal of physiology. Regulatory, integrative and comparative physiology

Kasai A,Jee E,Tamura Y,Kouzaki K,Kotani T,Nakazato K

Wed Jun 01 00:00:00 UTC 2022

β-RA Targets Mitochondrial Metabolism and Adipogenesis, Leading to Therapeutic Benefits against CoQ Deficiency and Age-Related Overweight.

Biomedicines

Hidalgo-Gutiérrez A,Barriocanal-Casado E,Díaz-Casado ME,González-García P,Zenezini Chiozzi R,Acuña-Castroviejo D,López LC

Wed Oct 13 00:00:00 UTC 2021

Acetaldehyde dehydrogenase 2 deficiency increases mitochondrial reactive oxygen species emission and induces mitochondrial protease Omi/HtrA2 in skeletal muscle.

American journal of physiology. Regulatory, integrative and comparative physiology

Wakabayashi Y,Tamura Y,Kouzaki K,Kikuchi N,Hiranuma K,Menuki K,Tajima T,Yamanaka Y,Sakai A,Nakayama KI,Kawamoto T,Kitagawa K,Nakazato K

Wed Apr 01 00:00:00 UTC 2020

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy.

eLife

Diaz Osterman CJ,Ozmadenci D,Kleinschmidt EG,Taylor KN,Barrie AM,Jiang S,Bean LM,Sulzmaier FJ,Jean C,Tancioni I,Anderson K,Uryu S,Cordasco EA,Li J,Chen XL,Fu G,Ojalill M,Rappu P,Heino J,Mark AM,Xu G,Fisch KM,Kolev VN,Weaver DT,Pachter JA,Győrffy B,McHale MT,Connolly DC,Molinolo A,Stupack DG,Schlaepfer DD

Tue Sep 03 00:00:00 UTC 2019

The murine hepatic sequelae of long-term ethanol consumption are sex-specific and exacerbated by Aldh1b1 loss.

Experimental and molecular pathology

Müller MF,Kendall TJ,Adams DJ,Zhou Y,Arends MJ

Wed Aug 01 00:00:00 UTC 2018

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

The Journal of pathology

Müller MF,Zhou Y,Adams DJ,Arends MJ

Sat Apr 01 00:00:00 UTC 2017

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

The Journal of pathology

Müller MF,Zhou Y,Adams DJ,Arends MJ

Sat Apr 01 00:00:00 UTC 2017

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

The Journal of pathology

Müller MF,Zhou Y,Adams DJ,Arends MJ

Sat Apr 01 00:00:00 UTC 2017

Effects of long-term ethanol consumption and Aldh1b1 depletion on intestinal tumourigenesis in mice.

The Journal of pathology

Müller MF,Zhou Y,Adams DJ,Arends MJ

Sat Apr 01 00:00:00 UTC 2017

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Molecular cell

Oberbeck N,Langevin F,King G,de Wind N,Crossan GP,Patel KJ

Thu Sep 18 00:00:00 UTC 2014

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Molecular cell

Oberbeck N,Langevin F,King G,de Wind N,Crossan GP,Patel KJ

Thu Sep 18 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: acetaldehyde dehydrogenase 5; aldehyde dehydrogenase 1 family, member B1; aldehyde dehydrogenase 1B1; Aldehyde dehydrogenase 5; Aldehyde dehydrogenase family 1 member B1; Aldehyde dehydrogenase X, mitochondrial; ALDH class 2; MGC2230

Gene Aliases: 2700007F14Rik; ALDH1B1; ALDH5; ALDHX

UniProt ID: (Human) P30837, (Mouse) Q9CZS1, (Rat) Q66HF8

Entrez Gene ID: (Human) 219, (Mouse) 72535, (Rat) 298079

Function(s)

aldehyde dehydrogenase (NAD) activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor molecular_function dehydrogenase oxidoreductase metabolite interconversion enzyme

Process(es)

carbohydrate metabolic process ethanol catabolic process ethanol oxidation metabolic process oxidation-reduction process biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ALDH1B1 Polyclonal Antibody

ALDH1B1 Antibody (15560-1-AP) in ICC/IF

Product Details

15560-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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