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Invitrogen
AMOT Polyclonal Antibody
Advanced Verification
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Product Details
PA5-64322
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human AMOT. Recombinant protein control fragment (Product #RP-103986).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2637914
Product Specific Information
Immunogen sequence: LSERLMQMSL ATSGVKAHPP VTSAPLSPPQ PNDLYKNPTS SSEFYKAQGP LPNQHSLKGM EHRG
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
Target Information
AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform
Gene Aliases: AMOT; KIAA1071
UniProt ID: (Human) Q4VCS5
Entrez Gene ID: (Human) 154796
vasculogenesis
in utero embryonic development
gastrulation with mouth forming second
establishment of cell polarity involved in ameboidal cell migration
chemotaxis
negative regulation of angiogenesis
actin cytoskeleton organization
regulation of cell migration
negative regulation of GTPase activity
cellular protein localization
hippo signaling
positive regulation of embryonic development
cell migration involved in gastrulation
blood vessel endothelial cell migration
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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