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A suggested positive control is mouse heart tissue lysate.
PA5-20950 can be used with blocking peptide PEP-1064.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.
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Protein Aliases: Anaphase-promoting complex subunit 10; APC10; Cyclosome subunit 10; DKFZp564L0562
Gene Aliases: 1500026N15Rik; A830003M23Rik; ANAPC10; APC10; DOC1
UniProt ID: (Human) Q9UM13, (Mouse) Q8K2H6
Entrez Gene ID: (Human) 10393, (Mouse) 68999, (Rat) 361389
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