Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Recommended positive controls: MCF-7.
Predicted reactivity: Mouse (99%), Rat (99%), Zebrafish (90%), Xenopus laevis (94%), Pig (99%), Chicken (97%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC10 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. It has been suggested that APC10 plays a role to regulate the binding of specific substrates to the APC/C complex, similar to that of coactivators.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Anaphase-promoting complex subunit 10; APC10; Cyclosome subunit 10; DKFZp564L0562
Gene Aliases: ANAPC10; APC10; DOC1
UniProt ID: (Human) Q9UM13
Entrez Gene ID: (Human) 10393
Molecular Function:
ubiquitin-protein ligase
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