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Invitrogen

APOC2 Polyclonal Antibody

2 Published Figures

3 References

View all (16) Apolipoprotein C2 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)
Published Figures (2)

Application

APOC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

APOC2 Antibody (PA5-102480) in IHC (P)

Immunohistochemistry analysis of APOC2 in mouse liver tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with APOC2 polyclonal antibody (Product # PA5-102480) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.

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Product Details

PA5-102480

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human APOC2(Accession P02655), corresponding to amino acid residues G2-K52.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2851882

Product Specific Information

Antibody detects endogenous levels of total APOC2.

Target Information

Apolipoproteins are protein components of plasma lipoproteins. The apolipoprotein C gene family encodes four homologous proteins designated apoC-I to -IV, which specifically modulate the metabolism of triglyceride-rich lipoproteins. The human apoC-I gene maps to chromosome 19q13.2 and is expressed primarily in the liver where it is activated when monocytes differentiate into macrophages. The human apoC-II gene maps to chromosome 19q13.2 and encodes a 79 amino acid single chain protein that is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input.

Cellular and molecular life sciences : CMLS

El-Darzi N,Mast N,Li Y,Pikuleva IA

Published figure using APOC2 polyclonal antibody (Product # PA5-102480) in Western Blot

Mon Jan 22 00:00:00 UTC 2024

Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice.

Metabolites

Palmisano BT,Zhu L,Litts B,Burman A,Yu S,Neuman JC,Anozie U,Luu TN,Edington EM,Stafford JM

Published figure using APOC2 polyclonal antibody (Product # PA5-102480) in Western Blot

Thu May 20 00:00:00 UTC 2021

Hepatocyte Small Heterodimer Partner Mediates Sex-Specific Effects on Triglyceride Metabolism via Androgen Receptor in Male Mice.

Metabolites

Palmisano BT,Zhu L,Litts B,Burman A,Yu S,Neuman JC,Anozie U,Luu TN,Edington EM,Stafford JM

Published figure using APOC2 polyclonal antibody (Product # PA5-102480) in Western Blot

Thu May 20 00:00:00 UTC 2021

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice.

iScience

Dalton GD,Oh SH,Tang L,Zhang S,Brown AL,Varadharajan V,Baleanu-Gogonea C,Gogonea V,Pathak P,Brown JM,Diehl AM

PA5-102480 was used in Immunohistochemistry (Paraffin), Western Blot to demonstrate G-protein-coupled receptor Smoothened in hepatocytes plays a regulatory role in sensing and feedback regulation of cholesterol balance driven by excess dietary cholesterol.

Fri Sep 24 00:00:00 UTC 2021

Bioinformatics

Protein Aliases: APC 2; APO C2; Apo CII; Apo-CII; APOC 2; ApoC II; apoC-II; APOC2 protein; ApoCII; Apolipoprotein C II; Apolipoprotein C-II; Apolipoprotein C2; Apolipoprotein CII; ApolipoproteinCII; MGC75082

Gene Aliases: APC2; APO-CII; APOC-II; APOC2; RGD1560725

UniProt ID: (Human) P02655, (Mouse) Q05020, (Rat) G3V8D4

Entrez Gene ID: (Human) 344, (Mouse) 11813, (Rat) 292697

Function(s)

lipid binding phospholipase activator activity protein homodimerization activity phospholipase binding lipase inhibitor activity lipoprotein lipase activator activity enzyme activator activity molecular_function apolipoprotein

Process(es)

retinoid metabolic process positive regulation of phospholipase activity positive regulation of triglyceride catabolic process positive regulation of very-low-density lipoprotein particle remodeling negative regulation of very-low-density lipoprotein particle clearance lipid catabolic process negative regulation of cholesterol transport cholesterol efflux phospholipid efflux triglyceride-rich lipoprotein particle remodeling chylomicron remodeling very-low-density lipoprotein particle remodeling chylomicron remnant clearance high-density lipoprotein particle clearance lipoprotein metabolic process cholesterol homeostasis negative regulation of catalytic activity reverse cholesterol transport positive regulation of fatty acid biosynthetic process negative regulation of lipid metabolic process negative regulation of receptor-mediated endocytosis positive regulation of lipoprotein lipase activity positive regulation of phospholipid catabolic process triglyceride homeostasis lipid metabolic process transport lipid transport lipoprotein transport response to drug positive regulation of catalytic activity

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APOC2 Polyclonal Antibody

APOC2 Antibody (PA5-102480) in IHC (P)

Product Details

PA5-102480

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Function(s)

Process(es)

Performance Guarantee

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