Product References
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages.
Stroke and vascular neurology
Zhang R,Dong Y,Liu Y,Moezzi D,Ghorbani S,Mirzaei R,Lozinski BM,Dunn JF,Yong VW,Xue M
701241 was used in Immunohistochemistry (Frozen) to examine the benefits of enhanced Liver X receptor signaling in experimental intracerebral hemorrhage.
Fri Dec 29 00:00:00 EST 2023
Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?
Aging cell
Zhang Z,Na H,Gan Q,Tao Q,Alekseyev Y,Hu J,Yan Z,Yang JB,Tian H,Zhu S,Li Q,Rajab IM,Blusztajn JK,Wolozin B,Emili A,Zhang X,Stein T,Potempa LA,Qiu WQ
Published figure using APOE recombinant monoclonal antibody (Product # 701241) in Immunocytochemistry
Mon Nov 01 00:00:00 EDT 2021
Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?
Aging cell
Zhang Z,Na H,Gan Q,Tao Q,Alekseyev Y,Hu J,Yan Z,Yang JB,Tian H,Zhu S,Li Q,Rajab IM,Blusztajn JK,Wolozin B,Emili A,Zhang X,Stein T,Potempa LA,Qiu WQ
Published figure using APOE recombinant monoclonal antibody (Product # 701241) in Immunocytochemistry
Mon Nov 01 00:00:00 EDT 2021
Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype-dependent pattern: A risk factor for Alzheimer's disease?
Aging cell
Zhang Z,Na H,Gan Q,Tao Q,Alekseyev Y,Hu J,Yan Z,Yang JB,Tian H,Zhu S,Li Q,Rajab IM,Blusztajn JK,Wolozin B,Emili A,Zhang X,Stein T,Potempa LA,Qiu WQ
Published figure using APOE recombinant monoclonal antibody (Product # 701241) in Immunocytochemistry
Mon Nov 01 00:00:00 EDT 2021
ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease.
Acta neuropathologica
Kang SS,Ahn EH,Liu X,Bryson M,Miller GW,Weinshenker D,Ye K
701241 was used in Western Blotting to show that ApoE4 selectively binds to the vesicular monoamine transporter 2 (VMAT2) and inhibits neurotransmitter uptake and that ApoE4 exacerbates Tau neurotoxicity by increasing VMAT2 vesicle leakage and facilitating AEP-mediated Tau proteolytic cleavage in the LC via DOPEGAL.
Thu Jul 01 00:00:00 EDT 2021
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease.
Molecular psychiatry
Xia Y,Wang ZH,Zhang J,Liu X,Yu SP,Ye KX,Wang JZ,Ye K,Wang XC
701241 was used in Western Blotting to find that C/EBPβ selectively promotes more ApoE4 expression versus ApoE3 in human neurons, correlating with higher activation of C/EBPβ in human AD brains with ApoE4/4 compared to ApoE3/3.
Fri Oct 01 00:00:00 EDT 2021
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
JCI insight
Cui H,Jiang D,Banerjee S,Xie N,Kulkarni T,Liu RM,Duncan SR,Liu G
701241 was used in Immunohistochemistry (Paraffin), Western Blot to determine that pulmonary apolipoprotein E was almost exclusively produced by monocyte-derived alveolar macrophages in mice with bleomycin-induced lung fibrosis.
Thu Mar 12 00:00:00 EDT 2020
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
JCI insight
Cui H,Jiang D,Banerjee S,Xie N,Kulkarni T,Liu RM,Duncan SR,Liu G
701241 was used in Immunohistochemistry (Paraffin), Western Blot to determine that pulmonary apolipoprotein E was almost exclusively produced by monocyte-derived alveolar macrophages in mice with bleomycin-induced lung fibrosis.
Thu Mar 12 00:00:00 EDT 2020
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
JCI insight
Cui H,Jiang D,Banerjee S,Xie N,Kulkarni T,Liu RM,Duncan SR,Liu G
701241 was used in Immunohistochemistry (Paraffin), Western Blot to determine that pulmonary apolipoprotein E was almost exclusively produced by monocyte-derived alveolar macrophages in mice with bleomycin-induced lung fibrosis.
Thu Mar 12 00:00:00 EDT 2020
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
JCI insight
Cui H,Jiang D,Banerjee S,Xie N,Kulkarni T,Liu RM,Duncan SR,Liu G
701241 was used in Immunohistochemistry (Paraffin), Western Blot to determine that pulmonary apolipoprotein E was almost exclusively produced by monocyte-derived alveolar macrophages in mice with bleomycin-induced lung fibrosis.
Thu Mar 12 00:00:00 EDT 2020
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
JCI insight
Cui H,Jiang D,Banerjee S,Xie N,Kulkarni T,Liu RM,Duncan SR,Liu G
701241 was used in Immunohistochemistry (Paraffin), Western Blot to determine that pulmonary apolipoprotein E was almost exclusively produced by monocyte-derived alveolar macrophages in mice with bleomycin-induced lung fibrosis.
Thu Mar 12 00:00:00 EDT 2020
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Huang YA,Zhou B,Nabet AM,Wernig M,Südhof TC
701241 was used in Western Blot to study ApoE activity on neurons, as a glia-secreted signaling molecule that, among others, enhances synapse formation. Using human neurons (male embryonic stem cell-derived) cultured in the absence of glia to exclude indirect glial mechanisms, we show that ApoE broadly stimulates signal transduction cascades.
Wed Sep 11 00:00:00 EDT 2019
Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury.
EBioMedicine
Wang W,Hou TT,Jia LF,Wu QQ,Quan MN,Jia JP
701241 was used in Western Blotting to identify the specific amyloid-Β oligomer assembly that contributes to neuronal injury and cognitive deficits.
Mon Apr 01 00:00:00 EDT 2019