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Product Details
14282-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARHGDIG Fusion Protein Ag5554 (1-225 aa encoded by BC047699)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLGLDACEL GAQLLELLRL ALCARVLLAD KEGGPPAVDE VLDEAVPEYR APGRKSLLEI RQLDPDDRSL AKYKRVLLGP LPPAVDPSLP NVQVTRLTLL SEQAPGPVVM DLTGDLAVLK DQVFVLKEGV DYRVKISFKV HREIVSGLKC LHHTYRRGLR VDKTVYMVGS YGPSAQEYEF VTPVEEAPRG ALVRGPYLVV SLFTDDDRTH HLSWEWGLCI CQDWKD (1-225 aa encoded by B C047699)
Target Information
The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTPbound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIalpha, Ly-GDI (also known as Rho GDIbeta and previously known as GDI/D4) and Rho GDIgamma. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: guanosine diphosphate (GDP) dissociation inhibitor 5, Rho associated; Rho GDI 3; Rho GDIgamma; Rho GDP dissociation inhibitor (GDI) gamma; Rho GDP-dissociation inhibitor 3; Rho-GDI gamma; Rho-GDI2; Rho-GDIgamma; RhoGDI gamma
Gene Aliases: ARHGDIG; Gdi5; Rho-GDI-3; Rho-GDI2; RHOGDI-3; RIP2
UniProt ID: (Human) Q99819, (Mouse) Q62160
Entrez Gene ID: (Human) 398, (Rat) 360500, (Mouse) 14570
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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