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Application
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ARHGEF17 Antibody (PA5-103351) in IHC (P)
Immunohistochemistry analysis of ARHGEF17 in mouse heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ARHGEF17 polyclonal antibody (Product # PA5-103351) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-103351
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ARHGEF17(Accession Q96PE2), corresponding to amino acid residues T1679-L1729.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852696
Product Specific Information
Antibody detects endogenous levels of total ARHGEF17.
Target Information
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 164 kDa Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; Tumor endothelial marker 4
Gene Aliases: 8030463K16; AI428794; ARHGEF17; AW558066; BC035332; KIAA0337; mKIAA0337; p164-RhoGEF; P164RHOGEF; TEM4
UniProt ID: (Human) Q96PE2, (Mouse) Q80U35
Entrez Gene ID: (Human) 9828, (Mouse) 207212
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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