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Product Details
PA5-72861
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARID1A antibody for an 18 amino acid peptide near the amino terminus of human ARID1A. The immunogen is within amino acids 580 - 630 of ARID1A.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718715
Target Information
This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARID domain-containing protein 1A; AT rich interactive domain 1A (SWI-like); AT rich interactive domain 1A (Swi1 like); AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; chromatin remodeling factor p250; h BM029; hELD; hOSA1; Osa homolog 1; OSA1 nuclear protein; SWI-like protein; SWI-SNF complex protein p270; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1; Swi1 like
Gene Aliases: 1110030E03Rik; ARID1A; B120; BAF250; BAF250A; BM029; C1orf4; CSS2; ELD; hELD; hOSA1; MRD14; OSA1; P270; SMARCF1
UniProt ID: (Human) O14497, (Mouse) A2BH40
Entrez Gene ID: (Human) 8289, (Mouse) 93760, (Rat) 297867
negative regulation of transcription from RNA polymerase II promoter
neural tube closure
cardiac chamber development
optic cup formation involved in camera-type eye development
chromatin organization
nucleosome disassembly
chromatin remodeling
maintenance of chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
nervous system development
chromatin modification
intracellular estrogen receptor signaling pathway
androgen receptor signaling pathway
forebrain development
glucocorticoid receptor signaling pathway
ATP-dependent chromatin remodeling
positive regulation of transcription, DNA-templated
cardiac muscle cell differentiation
placenta blood vessel development
toxin transport
biological_process
regulation of transcription from RNA polymerase II promoter
covalent chromatin modification
nucleosome mobilization
chromatin-mediated maintenance of transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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