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Bioss

ARNTL2/BMAL2 Polyclonal Antibody

View all (4) CLIF antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Product Details

BS-11446R

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500

Immunocytochemistry (ICC/IF)

1:100-1:500

ELISA (ELISA)

1:500-1:1,000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human ARNTL2, amino acids 381-480.

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: aryl hydrocarbon receptor nuclear translocator-like 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Basic helix-loop-helix ARNT-like protein 2; Basic-helix-loop-helix-PAS protein MOP9; bHLHe6; Brain and muscle ARNT-like 2; brain and muscle Arnt-like protein 2 variant d; brain-muscle-ARNT-like protein 2; Class E basic helix-loop-helix protein 6; CLIF; CYCLE-like factor; Member of PAS protein 9; MGC149671; MGC149672; PAS domain-containing protein 9; transcription factor BMAL2

Gene Aliases: 4632430A05Rik; Arnt4; ARNTL2; BHLHE6; BMAL2; CLIF; MOP9; PASD9

UniProt ID: (Human) Q8WYA1, (Mouse) Q2VPD4

Entrez Gene ID: (Human) 56938, (Mouse) 272322, (Rat) 362464

Function(s)

transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription factor activity, sequence-specific DNA binding protein dimerization activity E-box binding DNA binding signal transducer activity protein binding molecular_function basic helix-loop-helix transcription factor

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter circadian rhythm entrainment of circadian clock positive regulation of circadian rhythm positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter signal transduction rhythmic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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