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This gene encodes a protein that contains a mono-ADP-ribosylation motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known.
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Protein Aliases: ADP-ribosyltransferase 4 (DO blood group); ADP-ribosyltransferase 4 (Dombrock blood group); ADP-ribosyltransferase C2 and C3 toxin-like 4; ARTC4; CD297; Dombrock blood group carrier molecule; Ecto-ADP-ribosyltransferase 4; Mono(ADP-ribosyl)transferase 4; mono-ADP-ribosyltransferase 4; NAD(+)--protein-arginine ADP-ribosyltransferase 4; NAD(P)(+)--arginine ADP-ribosyltransferase; NAD(P)(+)--arginine ADP-ribosyltransferase 4
Gene Aliases: 4432404K01Rik; ART4; ARTC4; ATR4; CD297; DO; DOK1
UniProt ID: (Human) Q93070, (Mouse) Q9CRA0
Entrez Gene ID: (Human) 420, (Rat) 312806, (Mouse) 109978
Molecular Function:
transferase
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